I love this meme, I'm saving it lol
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I love this meme, I'm saving it lol
Then, the study continues to identify a previously unknown relation to prolactin:One key regulator of SC activity in the HF is the transcription factor nuclear factor of activated T cells c1 (Nfatc1), which is expressed in bulge SCs (Tumbar et al. 2004; Rhee et al. 2006; Horsley et al. 2008). Nfatc1 activity is directly regulated by the phosphatase calcineurin (CN), which dephosphorylates Nfatc1 to induce its nuclear translocation and transcriptional activity (Rao et al. 1997; Horsley and Pavlath 2002). Inactivation of Nfatc1 through skin-specific genetic knockout or treatment with cyclosporine A (CSA), an inhibitor of CN (Mattila et al. 1990), results in precocious activation of HF growth in mice (Paus et al. 1989; Gafter-Gvili et al. 2003; Horsley et al. 2008).
In simpler terms, calcineurin is at the start of this CN-Nfatc1-PRL-Stat5 axis. Thus, CN upregulates PRL receptor density, whereas Cyclosporine A directly kills the entire pathway. So far, CsA is the only compound that I ran across that directly downregulates PRL receptors. The study also continues to show that PRL, and by extension Stat5 induces "SC quiescence", which is the same as shortening anagen/inducing catagen in HFs (which we already knew). More on the catagen inducing effects of PRL can be read here, among others.In this study, we identified genetic changes associated with SC activation following administration of CSA, a robust activator of follicular SCs. Gene expression profiling revealed a novel molecular interplay between Nfatc1 and Prlr, implicating Prl signaling as a regulator of SC activity in the hair. Using pharmacological and genetic experiments in mice, we revealed that Prl signaling and Nfatc1 expression are required for the abrogation of hair growth during pregnancy. Furthermore, we demonstrated that direct administration of Prl promotes HF quiescence. Finally, we showed that Prl signaling activates Jak/Stat5 signaling in follicular SCs to maintain their dormancy. Our findings unveil a novel CN–Nfatc1–Prlr–Stat5 pathway that governs skin SC quiescence downstream from a systemic hormone.
This was at concentrations of 100nM, which can be achieved by a 1mcg/mL E2 topical. It is unknown what concentrations are achieved with oral/transdermal full HRT, because serum concentrations do not necessarily correspond to scalp concentrations. Of course, the positive effects of E2 will (massively) override the negative effects it has on PRL secretion (as shown in other papers mentioned in other posts of mine), but still it is something to be aware of. PRL should ideally be reduced (and receptors be blocked to prevent upregulation).Oestrogen treatment significantly upregulated PRL and PRLR immunoreactivity in selected skin and hair follicle compartments, at the gene and protein level (P < 0.05).
nw0 hairline?View attachment 170084
Slow but steady progress
can you show us crown too??View attachment 170084
Slow but steady progress
why don’t you recommend EE?Valerate and semihydrate (E2) are bioidentical estrogens, well tolerated and accepted by the body and have fewer side effects than ethinyl estradiol (EE).
I've taken both drugs, and if I had to choose, I'd prefer the half-hydrate - its molecular weight is less and it's more suitable for sublingual administration.
I've never taken EE and I don't recommend that crap to anyone.
If you take EE without E2/E3 support, the cup tilts toward stimulation of the ER-alpha receptor, which can cause premature catagen of the hair follicles.why don’t you recommend EE?
Yes. I got my first results on valerate.is estradiol valert good for hair?
No not really, it was minoxidilHas injections accelerated your progress?
Oral? Minoxidil must be helpful when follicles are hard to bring back to life. My hair is now growing back along the Norwood 0 line, so I'll do without itNo not really, it was minoxidil
My hairline is slowly going away and my crown is barebone, almost gone.Are you sure this is male pattern baldness ??
mikasa, which product for you hair do you use ?My hairline is slowly going away and my crown is barebone, almost gone.
I was thinking about wearing a hair system, but now even the sides and back... oof.
Dunno what to do. Just want to have great hair
I do like Mikasa, but my name is Sasha Braus.mikasa, which product for you hair do you use ?
Topical 5% i wouldn't want to grow hair on my backOral? Minoxidil must be helpful when follicles are hard to bring back to life. My hair is now growing back along the Norwood 0 line, so I'll do without it
can you show us crown too??