I love this meme, I'm saving it lol
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Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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What is the defference between Estradiol hemihydrate usually on topical gel and Estradiol Valerate?? Is it the same what is the best for hair thinning thickenning oral or topical no injectiions?
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Valerate and semihydrate (E2) are bioidentical estrogens, well tolerated and accepted by the body and have fewer side effects than ethinyl estradiol (EE).
I've taken both drugs, and if I had to choose, I'd prefer the half-hydrate - its molecular weight is less and it's more suitable for sublingual administration.
I've never taken EE and I don't recommend that crap to anyone.
I've taken both drugs, and if I had to choose, I'd prefer the half-hydrate - its molecular weight is less and it's more suitable for sublingual administration.
I've never taken EE and I don't recommend that crap to anyone.
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Dug up some cool research on prolactin (PRL) and its effects on scalp hair loss.
Calcineurin upregulates PRL receptor expression in human HFs
We already knew that our old friend Cyclosporine A inhibits calcineurin, and thereby potently upregulates stem cell (SC) differentiation. From the article:
More studies then. Bad news for E2 (and thyrotropin).
E2 increases PRL secretion and PRL receptor density in HFs
In conclusion, PRL receptor density is downregulated by CsA, but it is not a PRL receptor antagonist (so far, only the experimental antibody is). CsA increases SC differentiation and promotes anagen. It is unknown if other CN inhibitors like Tacrolimus can promote anagen to a similar extent as CsA, but they should all be able to potently downregulate PRL receptor density. Safety concerns aside, this makes them interesting compounds to consider for topical hairloss formulations (apart from its PRLr downregulating effect, CsA also inhibits sFRP1 (inducing the Wnt pathway) and inhibits several interleukins (ILs), thereby directly increasing SC differentiation and suppressing inflammitory responses).
Calcineurin upregulates PRL receptor expression in human HFs
We already knew that our old friend Cyclosporine A inhibits calcineurin, and thereby potently upregulates stem cell (SC) differentiation. From the article:
Then, the study continues to identify a previously unknown relation to prolactin:
In simpler terms, calcineurin is at the start of this CN-Nfatc1-PRL-Stat5 axis. Thus, CN upregulates PRL receptor density, whereas Cyclosporine A directly kills the entire pathway. So far, CsA is the only compound that I ran across that directly downregulates PRL receptors. The study also continues to show that PRL, and by extension Stat5 induces "SC quiescence", which is the same as shortening anagen/inducing catagen in HFs (which we already knew). More on the catagen inducing effects of PRL can be read here, among others.
More studies then. Bad news for E2 (and thyrotropin).
E2 increases PRL secretion and PRL receptor density in HFs
This was at concentrations of 100nM, which can be achieved by a 1mcg/mL E2 topical. It is unknown what concentrations are achieved with oral/transdermal full HRT, because serum concentrations do not necessarily correspond to scalp concentrations. Of course, the positive effects of E2 will (massively) override the negative effects it has on PRL secretion (as shown in other papers mentioned in other posts of mine), but still it is something to be aware of. PRL should ideally be reduced (and receptors be blocked to prevent upregulation).
In conclusion, PRL receptor density is downregulated by CsA, but it is not a PRL receptor antagonist (so far, only the experimental antibody is). CsA increases SC differentiation and promotes anagen. It is unknown if other CN inhibitors like Tacrolimus can promote anagen to a similar extent as CsA, but they should all be able to potently downregulate PRL receptor density. Safety concerns aside, this makes them interesting compounds to consider for topical hairloss formulations (apart from its PRLr downregulating effect, CsA also inhibits sFRP1 (inducing the Wnt pathway) and inhibits several interleukins (ILs), thereby directly increasing SC differentiation and suppressing inflammitory responses).
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nw0 hairline?
You seem to be returning to your original growth line.
Has injections accelerated your progress?
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can you show us crown too??
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why don’t you recommend EE?
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If you take EE without E2/E3 support, the cup tilts toward stimulation of the ER-alpha receptor, which can cause premature catagen of the hair follicles.
It can be used in combination therapy where E2/E3 will dominate.
But I do not advise to take ethinyl estradiol, it is a bad estrogen with a high risk of venous thrombosis.
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is estradiol valert good for hair?
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Yes. I got my first results on valerate.
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No not really, it was minoxidil
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Oral? Minoxidil must be helpful when follicles are hard to bring back to life. My hair is now growing back along the Norwood 0 line, so I'll do without it
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Are you sure this is male pattern baldness ??
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My hairline is slowly going away and my crown is barebone, almost gone.
I was thinking about wearing a hair system, but now even the sides and back... oof.
Dunno what to do. Just want to have great hair
mikasa, which product for you hair do you use ?My hairline is slowly going away and my crown is barebone, almost gone.
I was thinking about wearing a hair system, but now even the sides and back... oof.
Dunno what to do. Just want to have great hair
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I do like Mikasa, but my name is Sasha Braus.
Cannot use medications, the doctor said. Due to having an inexplicable hormonal imbalance.
Letting it go and probably just forgetting about it, my meat is more important to me, Sasha said.
Goddes bless, holy Ymir!
OMG, I feel for you @Pls_NW-1 , that hair situation and so much health problems at your young age must be really challenging for you. I thought I had it bad with balding starting at 17 and my demanding skin, but at least I can treat it as I have nothing standing in the way health wise.
I tried accepting hair loss, but in my situation it was impossible, I hope you find it easier if it's your only choice, but still I hope your hair and health situation gets better at some point. Miracles do happen, I thought my mum would never get better, but she did after finding good treatment and doctors after years of neglect from most local medical professionals.
I tried accepting hair loss, but in my situation it was impossible, I hope you find it easier if it's your only choice, but still I hope your hair and health situation gets better at some point. Miracles do happen, I thought my mum would never get better, but she did after finding good treatment and doctors after years of neglect from most local medical professionals.
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