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Setipiprant is a selective oral antagonist of the CRTH2 receptor, a receptor where Prostaglandin D2 binds. George Cotsarelis discovered that Prostaglandin D2 seems to play a notable role in hair loss.
Prostaglandin D2 has been found elevated in regions of the male scalp associated with hair loss. Therefore, interfering with this PGD2 receptor could be a potential treatment for hair loss with the promotion of hair growth, or to inhibit the miniaturization process.
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