The Most Extreme Topical Anti Hairloss Protocol Log
- Thread starter hemingway_the_mercenary
- Start date
- Reaction score
- 51
Take a look at this pic, you think I could recover my crown?
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- Reaction score
- 528
I think you can regrow. You need to try a more aggressive topical regiment tho
- Reaction score
- 51
Answer: Large clinical studies with thousands participants showed that minoxidil concentration had to be greater than 20 ng/mL to give systemic effects.
5% minoxidil solution has 1.2 ng / mL of minoxidil in the serum.
Thus, there is more than a 16-fold safety margin from the use of 5% topical minoxidil
There is more than 5-fold safety margin with the use of a 15% topical minoxidil solution assuming the serum concentration is tripled when the topical minoxidil is increased from 5% to 15%.
In reality, the serum concentration should be less tripled.
Thus the safety margin is more than 5-fold.
Nonetheless, the product has minoxidil, thus people are strongly recommended to be vigilant about all the listed side effects when using 15% minoxidil.
5% minoxidil solution has 1.2 ng / mL of minoxidil in the serum.
Thus, there is more than a 16-fold safety margin from the use of 5% topical minoxidil
There is more than 5-fold safety margin with the use of a 15% topical minoxidil solution assuming the serum concentration is tripled when the topical minoxidil is increased from 5% to 15%.
In reality, the serum concentration should be less tripled.
Thus the safety margin is more than 5-fold.
Nonetheless, the product has minoxidil, thus people are strongly recommended to be vigilant about all the listed side effects when using 15% minoxidil.
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Sanchez1234
Experienced Member
- Reaction score
- 311
Gyno is always my problem when trying duta or finasteride. Is there really something like a spray to counteract it? I doubt it..
- Reaction score
- 50
Try metformin, it got other health benefits too.
Sanchez1234
Experienced Member
- Reaction score
- 311
Metformin for what?
- Reaction score
- 50
Metformin works as a breast specific aromatase inhibitor
https://www.researchgate.net/public..._metformin_on_aromatase_transcript_expression
- Reaction score
- 528
- Reaction score
- 528
I have added finasteride at 0.04 mg per ml in my Daro. Daro by itself is too weak to fight of local DHT so this amount of finasteride at 2x per day gives me 0.160mg topically which should be the equivalent of oral 1mg at least, hopefully with less side effects
Sanchez1234
Experienced Member
- Reaction score
- 311
What exactly does your topical contain so far?
How is the shedding?
el_duterino
Senior Member
- Reaction score
- 395
Any sexual sides on Daro?
- Reaction score
- 528
at 14mg yes, when I keep it below 8 (total daily dose) I dont notice any
I dont think this is the drug for you tho, you need to apply 2x a day and if ru and cb work so great for you there is no need to move on to something like this
Sanchez my shedding very low, only picks up after 10 hours of not applying Daro. The itching window seems to have gotten longer after I added finasteride to the solution. I already gave my theory for why this is. What I really need now is estradiol to downregulate and desensitize my androgen receptors (see my other thread on that)
The worst part of Daro I have to say is having all the oil in your head from the kb. What I had been doing was only taking a shower after 4 applications because I didnt want to get oil on my scalp right after washing it. But recently I did an experiment where I applied the Daro and waited for about 1 hours and washed the hair and it seems that its almost the same as if I hadnt washed it so I will start doing it more. Hopefully it works. There is no question in my mind that Daro increases receptor sensitivity now
Rn the only think in my solution is Daro and finasteride
- Reaction score
- 50
Why adding Polysorbate 20 and Laureth 3 to your kb, when PEG 40 is what being used? What mix ratio are you considering?
- Reaction score
- 528
I am not, I just bought them to see how they would be as a vehicle. Thats why I bought smaller bottles of them.
el_duterino
Senior Member
- Reaction score
- 395
So I guess the assumption on blocking the brain blood barrier to avoid sexual effects does not hold water
We know that Daro does not cross the BBB so sides must come from other body parts AR
We know that Daro does not cross the BBB so sides must come from other body parts AR
- Reaction score
- 528
well i can tell you that that part about Daro is very sweet and desirable but of course if you block androgen receptors in the penis its not going to work as well
adding finasteride topically was a great idea I have to say. The gaps I have now before the itching comes on are about 2 hours longer and the itching is more mild and doesnt cause me to shed that insane amount.
- Reaction score
- 51
Daro still has small blood-brain barrier penetration. Most sources call it "negligible" but I think some guys are sensitive to it. It could still be off-target GABAA inhibition like enza.
@hemingway_the_mercenary
Did you have similar side effects on topical bica?
Also I like that idea of topical fina with daro. Hopefully that frees up DHT receptors so the daro can bind immediately.
@hemingway_the_mercenary
Did you have similar side effects on topical bica?
Also I like that idea of topical fina with daro. Hopefully that frees up DHT receptors so the daro can bind immediately.
- Reaction score
- 528
no i started to develop gyno on bica on daro i feel much less side effects