Finasteride and dutasteride do not block the AR, so why would it happen with them? Testosterone, and smaller amounts of DHT, are still attaching to the AR and activating it. AR upregulation is known to occur in prostate cancer cells. They use drugs for prostate cancer that are almost insurmountable. They outcompete DHT for the receptor, and are able to overcome AR upregulation. Then you have mutant AR to deal with, and that's another issue. Why is it so far-fetched to think upregulation might happen in the scalp when we know it happens in prostate cancer cells? It's not the same thing and I'm not saying it happens, but what other explanation is there for these results from Cassiopea? The rigor participation argument doesn't hold water, unless you believe people who sign up for minoxidil trials are more rigorous.
So am I right in thinking if this were true that all androgen receptor antagonists such as breezula, ru58841, fluridil (eucapil) or even kintors upcoming pyrilutamide will eventually upregulate the number of androgen receptors and thus accelerate hair loss?