This study is looking specifically at during times of an energy deficit, such as a 28 day diet and 55% reduction in energy consumption. How would this apply to taking 5 AR in normal conditions? Of course the body is going to adapt to severe changing conditions, but a 10% increase in T in normal conditions should do absolutely nothing.
As I commented separately, this theory of AR upregulation is pure nonsense. Without even knowing the science behind it and just using common sense, if these guys are about to f*** over a bunch of kids and turbo charge their severe acne then they are going bankrupt from legal costs. This isn't a "big pharma" company that can just eat tens of millions in class action lawsuit defenses.I've been doing some more digging into the "anti androgen receptor and AR upregulation" theory and I came across a 12 month study of fluridil where between the 6 and 12 months there was not a decrease in efficacy which was seen between the 6-12 months on the Breezula (CB-03-01) 7.5% phase II study.
View attachment 152674
Based on this, this either means one these things:
1) The AR upregulation theory does not apply to fluridil
2) The study results were tampered
3) The AR upregulation theory is not true and there is another reason to why breezula (CB-03-01) 7.5% lost efficacy after 6 months.
Source:
Fig. 3. Statistical analysis of average percent anagen (A) and telogen...
Download scientific diagram | Statistical analysis of average percent anagen (A) and telogen (B) hair count throughout a 12-month clinical study of topical 2% fluridil therapy for androgenetic alopecia in 43 human male volunteers (23 fluridil group and 20 placebo group). Hair counts were derived...www.researchgate.net
People buy the raw chemical from china and mix it themselves, then they complain that it doesn't work.
Other people wait for an FDA approved OTC treatment, while bitching about them balding till this eventually happens. Pick up your camp.
Probably going to choose the camp where I know what I'm putting on my head. Don't get me wrong I'd love to try CB now, but I fee a lot of people just ordering off alibaba without testing.
Yes, and as soon as someone tests their purchased powder, they find out that they got something else and not what they ordered.
Lol exactly. There is even a thread here where the person is saying the stuff they bought from kane was less then 50% CB.
People have been using cb way longer than 2019
In what dosage though? I find it hard to believe that anyone was really doing 7% twice daily before the phase 2 trials.
First time I used it was in 2011 or 2012. This was the crystalline form which required a multi-step process to mix. The second time was in 2018 and regrettably I used stemoxydine as a vehicle.
What dosages total? That's my main issue with the anecdotes about people trying it in this thread. Due to how expensive this stuff is and the data we now have, I highly doubt people who have been trying this were using the 7.5% twice daily, let alone 2% twice a day.
Unfortunately you don't actually know much more then that it costs a fortune. Maybe a single person on this thread has stated they were using the dosage that will actually be evaluated in the phase 3 studies, and the rest probably used it for far less then would actually be required to judge efficacy. We either need to wait for people to get the real stuff compounded via winlevi or the actual phase 3 studies, because this stuff can't be sourced well enough for real trials on a forum.