The Cb (breezula [clascoterone]) Community Thread | Page 66 | HairLossTalk Forums

The Cb (breezula [clascoterone]) Community Thread

Discussion in 'New Research, Studies, and Technologies' started by Screeech, Jun 25, 2019.

  1. Dimitri001

    Dimitri001 Established Member My Regimen

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    Well, it works through a different mechanism than minoxidil, so it's not a foregone conclusion that the gains would go in the same time period.

    Would one month off of it be enough, I have no idea, but I don't know that a week off of it wouldn't be enough if you go off before the 6 month mark when the AR desensitization sets in (if that's the proper way to understand the reason for it losing effectiveness). I guess, if this would work at all, it would partly depend on how long CB stays in the follicles.

    But, again, I don't know anything about ARs and how any of this works, so my little hypothesis may be a complete non-starter.
     
  2. telogen

    telogen Established Member My Regimen

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    Upregulating AR with stuff like CB, ru and oh-flut is dead real in my experience. This don't appear to be happening with topical finasteride, which keeps having stable effect over long periods. The problem with finasteride is the unchecked T which accumulates in the scalp and does damage. Upping the dose with something like ru unlimited is also not doable, because you will run into serious sides like gyno in the end.
    I've been trying to cycle oh-flut on and off in 30 days spans, and it appears to work, but i don't have anything similarly potent to use
    when off oh-flut. Maybe an SFRP1 inhibitor like way-316606??
     
  3. bucksins6x

    bucksins6x Established Member My Regimen

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    Any sides on oh-flut?
     
  4. telogen

    telogen Established Member My Regimen

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    Non on 100 mg which maintains.
    With ru i was needing 200 mg ed which in the end gave me gyno and forced me to quit.
    I'm sure this was a case of upregulated ar
     
  5. pegasus2

    pegasus2 Senior Member My Regimen

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    I suggest trying an Androgen receptor degrader for a while to see if you can reverse that.
     
  6. John Difool

    John Difool Senior Member My Regimen

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    I'd really like to get my hands on some proxalutamide
     
  7. John Difool

    John Difool Senior Member My Regimen

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    Such as ASC-J9?
     
  8. pegasus2

    pegasus2 Senior Member My Regimen

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    Yes.
     
  9. Upnadam10

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    How long have you been on dutasteride? Hard to find success stories on dutasteride on this site. Please share
     
  10. John Difool

    John Difool Senior Member My Regimen

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    What? Hard to find success stories?! It depends what you mean by success! If you expect regrowth from popping an AA pill, sure you are in for disappointment. As far as maintenance, it's much better than Fina and there are plenty of material on this. Of course doctors in the US are being greased by Big Pharma to script Fina so that's not as popular in the States.
     
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  11. Jim lahey

    Jim lahey Established Member My Regimen

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    That graph only goes up to 12 months and is still above baseline so we don't know that happens after 12 months. Its an anti androgen and from what it looks like a pretty mild one so huge gains aren't to be expected.
     
  12. Jim lahey

    Jim lahey Established Member My Regimen

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    Cycling probably won't give you better results because once you get off it your receptors are going to be very sensitive to androgens.
     
  13. wilfred

    wilfred Established Member My Regimen

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    Anyone in Canda want my unopened CB pm me.
     
  14. Dimitri001

    Dimitri001 Established Member My Regimen

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    Well, the trend is pretty sharply downwards going from 6 to 12 months, so plummeting further seems like the reasonable guess, sadly.

    Are you sure that that's how it works or guessing? It seems like they are getting less sensitive to CB, so the more reasonable assumption seems to be that, if anything, they're gonna be less sensitive.

    I wish we had someone in here who was knowledgeable about this stuff and could give us an authoritative answer on this cycling hypothesis.

    But anyway, even if what you say is true, it's still possible that you'll be at a net gain with, say, cycles of 6 months being on it and a week or a month of being off it.
     
  15. Dimitri001

    Dimitri001 Established Member My Regimen

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    I know nothing about hormones and ARs, so if I'm conceptualizing this the wrong way someone please set me straight, but regarding this AR desensitization/upregulation explanation of the diminishing effectiveness, my understanding is that CB binds to the AR so that DHT can't. It takes up its place, so to speak.

    If that is so, I don't see how desensitization can explain the diminishing returns, because CB isn't having any effect to begin with, it's just taking up space. There's no positive CB effect that can be diminished though desensitization, because CB doesn't have an effect.

    Or is it that desensitization is supposed to mean that the ARs' affinity for binding with CB goes down? That also seems kinda dubious, because, in absence of CB, it's exposed to DHT constantly, so that effect should be present with DHT, too. Unless there's a cutoff point - meaning the binding affinity goes down with constant exposure, but it never gets to the point where it won't bind, so it will just keep binding with DHT even as its affinity for it goes down, because DHT is the only game in town.
     
  16. sonictemples

    sonictemples Experienced Member My Regimen

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    Wouldn't bica cure that
     
  17. pegasus2

    pegasus2 Senior Member My Regimen

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    @Dimitri001 What people are talking about is more receptors being created. CB doesn't bind to every receptor. The more receptors there are the more CB is needed. Worse, but unlikely, would be receptors mutating to be activated by CB.
     
  18. Throwaway94

    Throwaway94 Experienced Member My Regimen

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    I *think* the main question there is why people believe CB would cause upregulation to begin with whereas other things that bind to the same receptor don't.

    I know there's broscience out there talking about upregulation due to some people's experience of it becoming less effective over time and the decline in the breezula trial, but we have yet to see evidence of upregulation beyond that of what people who are going bald seem to have naturally. What's your take on this?
     
  19. pegasus2

    pegasus2 Senior Member My Regimen

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    Who says other things don't? A lot of people believe that RU does the same thing. None of the other topical AAs have ever gained much popularity. There's certainly no evidence that there is AR up regulation in the HF, but I don't see any other reasonable explanation for CB getting outperformed by placebo. People talking placebo are already going bald too.
     
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  20. Throwaway94

    Throwaway94 Experienced Member My Regimen

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    I don't know if other things do or don't that part was my interpretation of Dimitri's question.

    I don't doubt there is upregulation, but what is there to suggest it wouldn't happen either way? As far as some concs of Breezula being outperformed by placebo, we know it was a small sample and don't have any other details regarding the measurements so I'll reserve judgement there
     

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