This is the absolute crux of the matter as far as the wider implications of taking finasteride are concerned. I haven't read extensively about the men with 5AR deficiency and I'm not a doctor, but what I have seen online typically says something like "males with genetic deficiency of...
I agree with somone uk - you can't necessarily extrapolate results in rats to humans. First, finasteride inhibits *both* types of 5AR, I and II, in rats. In humans it's basically selective for type II. Mew actually addresses this on propeciahelp...
DHT binds to the androgen receptor with about five times greater affinity than T. All other things being equal, a large reduction in DHT and a small increase in T should be beneficial for hair - even if we accept that both can 'damage' hair directly (and the jury's still out). This is certainly...
Perhaps there is an explanation for your experience: maybe your estrogen levels have increased significantly since starting finasteride. In previous threads the consensus of more-experienced posters was that estrogen could have a suppressive effect on the growth of body hair, and a stimulatory...
I've been on finasteride for a little over two years now. I'd didn't see easily-perceptible regrowth but further loss definitely halted (I noticed the reduction in daily shedding around month 3) and there was possibly some modest thickening over the first year. I think that my hair is kinda...
I think Bryan has posted a few times that there are in-vitro experiments showing T can affect hair follicles directly. However, we still have the conundrum that 5AR-deficient men have normal or slightly-elevated T levels and don't appear to lose their hair.
There is nothing wrong with Teva's generic finasteride (as long as you have a legitimate source). Teva's product is rated as bioequivalent to Merck Proscar and Teva is a big, reputable manufacturer. I think Teva finasteride is used in the British NHS...
http://www.nelm.nhs.uk/Record%20Viewing...
Shampoos with vitamins etc are totally pointless, because hair is dead. I tend to prefer gentle shampoos with mild surfactants like the Aveda Pure-formance - it's expensive though.
There was a study where an aromatase inhibitor was used to treat BPH, which is similarly suspected of being 'caused' by increased estrogen. The AI raised DHT and decreased estrogen levels, but had no effect on the condition compared to placebo. Bryan has posted the study a few times...
I didn't realise that DHT could be converted into a form of estrogen (page 8 of the link). That's interesting. Many posters say that one of the 'risks' of 5AR inhibitors is that T cannot be converted into DHT, therefore estrogen levels go up - and we know they do, from the studies and the...
Re: propecia false claims
It gets less effective with time - At 12 months, 58% of men in the placebo group had further hair loss (defined as any decrease in hair count from baseline), compared with 14% of men treated with PROPECIA. In men treated for up to 2 years, 72% of men in the placebo...
Nourkrin do a shampoo? I thought that they just made a nutritional supplement. Both are a waste of time in my opinion.
http://www.baldingblog.com/2006/09/12/n ... -regrowth/
http://www.baldingblog.com/2007/09/04/d ... block-dht/