The Cb (breezula [clascoterone]) Community Thread

Dimitri001

Established Member
My Regimen
Yes, we're still on.
 

SimonC

Established Member
My Regimen
Do we have any news about the CLASCOTERONE solution 7.5%? I see that 1% is about to hit the market

I assume covid has shifted plans significantly.
 

tomJ

Senior Member
My Regimen
Do we have any news about the CLASCOTERONE solution 7.5%? I see that 1% is about to hit the market

I assume covid has shifted plans significantly.
Should be approved soon (1%) but not sure if will get on shelves any time soon.
 

Dimitri001

Established Member
My Regimen
Group buy guys, could you please PM me your email addresses so I can contact you if the forum goes down again?
 

John Difool

Senior Member
My Regimen
75mg*2ml*twice a day = 1 month of supply with 10g. So you will need 6 times this amount to reach results. 60g at $400/10g is $2,400. With a group buy it's $1,800 which should be what everyone jumping on this test should be ready to invest to maintain without supposedly sides. And after 6 months you are probably on your own or looking for a more powerful treatment like RU which is cheaper so why not using this in the first place?
 

The_Dragon

Member
My Regimen
I am using it in the first place haha. I'm currently taking RU 25mg, I got chest and sexual sides on 50mg and even that isn't considered high :/. Been using it for a month or so, not entirely sure if it's working yet. We need to find long term solutions, and RU trials were abandoned unfortunately so I would feel much more comfortable taking something which has been more extensively tested if having to use it long term (also wanna try topical liposomal duta), even tho it's not meant to be as powerful. Price will lower over time
 
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Dimitri001

Established Member
My Regimen

Chowmane

New Member
My Regimen
Question, what would you use as a vehicle for Cb? And what would be the easiest, most convenient way to mix it? Like how much would you mix with how much of whatever? Thank you in advance.
 

pegasus2

Senior Member
My Regimen
Question, what would you use as a vehicle for Cb? And what would be the easiest, most convenient way to mix it? Like how much would you mix with how much of whatever? Thank you in advance.

Just go get an off label prescription and have it compounded by the pharmacy. It will be just as cheap as buying the raw powder if not cheaper.
 

bluecyclone

Senior Member
My Regimen
Damn so the 5g CB I bought is pretty much useless? I have a 3 year old 10g freezer packet of RU. I’m fucked. Propecia not doing sh*t even with sides.
 

Dimitri001

Established Member
My Regimen
How many more people do we need now?
Also did you get my pm? can't quite figure out this websites layout lol

I need to get in contact with everyone on the list to see whether everyone's still up for it and then if we still have most of the crowd with us we're pretty much ready to move forward.

I haven't checked my PMs yet, sorry everyone, I've been terribly busy last few days, but bear with me, I'm getting to it...
 

Dimitri001

Established Member
My Regimen
Eh, so, guys, most group buy guys didn't PM me their email address, which makes me worried about whether they're still on board. I figure at least some of the absences are due to people not having realized yet the forum's back, so hopefully they'll trickle in, but if you are reading this, please do PM me just so I know you're still with us.

Did Cassiopea publish an actual paper on the dosing study, besides the results reported in the press release? I can't find one on Google Scholar.

By the way, this is not much, but a group of researchers including a guy who's worked on some Winlevi studies have published a paper a few days ago about using CB-03-10 (note, not CB-03-01) as a potential treatment for tumors that have developed "GR-mediated resistance to AR blockade."

Overall, these preclinical findings support the selection of CB-03-10 for further development as an anticancer agent in cases where resistance to AR-targeted therapy or chemotherapy, via upregulation of GR activity, continues to limit the efficacy and duration of clinical benefit with these interventions.

This is of course wild speculation and BLATANT wishful thinking and grasping at straws on my part, but perhaps this is a bit of research that came out of AR blocking problems they came up against with Androgenetic Alopecia and that this is indication that they're working on the problem. Maybe this upregulation of GR activity is some indication as to why CB runs into problems?

Of course, I'm probably being silly here.

UPDATE: From the paper:

In addition to these mechanisms, a number of studies have shown that GR signaling can
potentially drive CPRC growth by activating a transcriptional program similar to the AR, thus
bypassing AR blockade (4-6). It has recently been documented that GR expression is
significantly increased following long-term ADT (androgen deprivation therapy) with abiraterone or enzalutamide (Enza) in a
number of preclinical models, indicating that GR upregulation is one possible mechanism of AR
resistance in CRPC (6). Therefore, despite the efficacy of anti-androgens in the short term, the
development of anti-androgen-resistant tumors in CRPC represents a significant challenge in the
treatment of advanced prostate cancer. GR can bind to and drive the expression of a subset of AR
target genes, thus allowing the cancer to progress despite ongoing AR blockade.

I don't know, I'm beginning to convince myself. We know that anti-androgen therapies that target hair loss also work on the prostate and the ARs there. This may be the same mechanism that's involved with CB.
 
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