The Cb (breezula [clascoterone]) Community Thread

Jim lahey

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Sooo whatsup with the group buy?? Any better quotes on prices? If anybody hasn't already I'll organize a sample buy and get it tested once we've decided on the vendor.
 

John Difool

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Group buys need commitment from people who really want to do something about their baldness not just bitching when Tsuji will release his treatment while they can't even pay for 1 week of this powder.
 

Dimitri001

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Sooo whatsup with the group buy?? Any better quotes on prices? If anybody hasn't already I'll organize a sample buy and get it tested once we've decided on the vendor.

I still haven't heard from most people and I was hoping that eventually I would, but it's been a while now since the forum's been back, so, yeah, maybe we should start thinking about cutting our losses and going with the people we have right now...
 

Chowmane

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Mixing with cream won't dissolve the powder if the cream is water based. It's tricky because cream unlike liquid vehicle doesn't show precipitation. You need to dissolve it with a solvent first. In case of CB, Ethanol or Ethoxydiglycol.
Thank you for your reply. As I plan on using a liquid vehicle, would you recommend a standard ratio or a premix from a reputable supply site in which the Cb can be added and the best ratio for that?
Thank you.
Pardon the questions. I'm relatively new to this and the vehicle part and the most efficient ratios are confusing.
 

John Difool

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You really want to make it yourself. Adding to a vehicle containing water already is almost impossible unless you use a magnetic stirer. Buy Eth and PG Dissolve in Eth and add PG 50:50
 

nick123

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Finasteride and dutasteride do not block the AR, so why would it happen with them? Testosterone, and smaller amounts of DHT, are still attaching to the AR and activating it. AR upregulation is known to occur in prostate cancer cells. They use drugs for prostate cancer that are almost insurmountable. They outcompete DHT for the receptor, and are able to overcome AR upregulation. Then you have mutant AR to deal with, and that's another issue. Why is it so far-fetched to think upregulation might happen in the scalp when we know it happens in prostate cancer cells? It's not the same thing and I'm not saying it happens, but what other explanation is there for these results from Cassiopea? The rigor participation argument doesn't hold water, unless you believe people who sign up for minoxidil trials are more rigorous.

So am I right in thinking if this were true that all androgen receptor antagonists such as breezula, ru58841, fluridil (eucapil) or even kintors upcoming pyrilutamide will eventually upregulate the number of androgen receptors and thus accelerate hair loss?
 

pegasus2

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So am I right in thinking if this were true that all androgen receptor antagonists such as breezula, ru58841, fluridil (eucapil) or even kintors upcoming pyrilutamide will eventually upregulate the number of androgen receptors and thus accelerate hair loss?

Yes and no. If you stay on the drug it probably won't accelerate your hair loss, but it might stop working unless you increase the dosage.
 

pegasus2

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But there would be a max threshold of how much AR receptors actually can upregulate? So if I am on a high enough dosage it shouldn’t make a difference if AR upregulates. Im on 120 mg of RU.
Right. If you increase the dosage enough then it shouldn't matter. Just if you come off the drug you are going to go through a massive shed until it downregulates, if it downregulates.
 

nick123

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But there would be a max threshold of how much AR receptors actually can upregulate? So if I am on a high enough dosage it shouldn’t make a difference if AR upregulates. Im on 120 mg of RU.

Why is there an assumption there's a max threshold to what it can upregulate?

Right. If you increase the dosage enough then it shouldn't matter. Just if you come off the drug you are going to go through a massive shed until it downregulates, if it downregulates.

This also worries me, if it doesn't downregulate and come off your androgen receptor antagonist your hair will loss will accelerate at a much faster pace than if you didn't start your androgen receptor antagonist at all.

This is all starting to really disappoint me, I've never been able to maintain on 4x dutasteride + 3x finasteride per week and there's absolutely nothing in the pipeline that seems useful.
 

Fgsfds

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Right. If you increase the dosage enough then it shouldn't matter. Just if you come off the drug you are going to go through a massive shed until it downregulates, if it downregulates.
If this happens, then you'd want to at least block the downstream factors like PGD2 and DKK1 until your AR receptors normalize
 

LouisSarkozy

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If this happens, then you'd want to at least block the downstream factors like PGD2 and DKK1 until your AR receptors normalize
anything somehow safe to block dkk1? i'm using prostaquinon and ceti for pgd2 but was still receeding on dutasteride
 

nick123

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Ceti as in Setipiprant? It's total garbage even at 2g a day.

I think he means cetirizine hydrochloride, which is known to reduce PGD2.

Edit: I'm pretty sure I read somewhere cetirizine hydrochloride also reduces PGE2 which isn't a good thing? Does anyone else if this is true?
 

LouisSarkozy

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I think he means cetirizine hydrochloride, which is known to reduce PGD2.

Edit: I'm pretty sure I read somewhere cetirizine hydrochloride also reduces PGE2 which isn't a good thing? Does anyone else if this is true?
thanks i saw mixed studies one saying it's a cox2 inhibitor so reducing pge2 and some saying it actually increase pge2 but i'm not sure. got it coumpounded in trichosol recentrly to trial on my hairline
 

nick123

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thanks i saw mixed studies one saying it's a cox2 inhibitor so reducing pge2 and some saying it actually increase pge2 but i'm not sure. got it coumpounded in trichosol recentrly to trial on my hairline

Interesting, well good luck and report back!
 

nick123

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Right. If you increase the dosage enough then it shouldn't matter. Just if you come off the drug you are going to go through a massive shed until it downregulates, if it downregulates.

If the upregulation of androgen receptors when using androgen receptor antagonists is really true, then why haven't we noticed accelerated loss with RU58841 users after 6 months or am i missing something?!
 
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