Can you please tell me where to buy SMI?Fair enough. All I can say is that I've been taking that stack for 6 months and didn't have any regrowth. I then took oral SMI and saw improvements, fast. So you're free to interpret that how you see fit.
Can you please tell me where to buy SMI?Fair enough. All I can say is that I've been taking that stack for 6 months and didn't have any regrowth. I then took oral SMI and saw improvements, fast. So you're free to interpret that how you see fit.
Lo Compre en una compra de grupo con unos de aqui. No se so habra otra compra.He estado usando parte de su régimen durante años, excepto SMI, así que creo que su mejora es para eso.
Pido disculpas si hay en la banda de rodadura, pero ¿cómo se obtiene SMI y dónde puedo comprarlo?
thank so much
I don't have before pictures of my sides and back in afraid. Anyway, I was on finasteride for around a year and didn't see any regrowth. I switched to dutasteride, which I think is better.Can you show your sides and back ? I have dupa and i take fina since 10 month but its not working.
Dutasteride work on you ?
That regrowth looks really good. Did you note any side effects, starting smi?Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.
Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 30mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg
Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 30mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)
- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week
View attachment 164863
View attachment 164864
Not really. Some people claimed vivid dreams but I didn't notice.That regrowth looks really good. Did you note any side effects, starting smi?
You take metformin, rapamycin, and fisetin + querecetin for anti aging?Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.
Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 30mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg
Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 30mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)
- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week
View attachment 164863
View attachment 164864
Yup, along with Hyaluronic Acid, Pure Apigenin, Niacin, and Pure TMG. They're meant to boost NAD.You take metformin, rapamycin, and fisetin + querecetin for anti aging?
Why not just take NMN in that case?Yup, along with Hyaluronic Acid, Pure Apigenin and Pure TMG. They're meant to boost NAD.
How long have you been on SMI for?Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.
Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 30mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg
Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 30mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)
- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week
View attachment 164863
View attachment 164864
Why does everybody take NMN when it has to be converted to NR before it can be absorbed?Why not just take NMN in that case?
I don't think this has been proven. SLC12A8 is expressed in humans and it can transport NMN across the cell membrane. NMN is the direct precursor to NAD+ so it would be more efficient than NRWhy does everybody take NMN when it has to be converted to NR before it can be absorbed?
I don't think this has been proven. SLC12A8 is expressed in humans and it can transport NMN across the cell membrane. NMN is the direct precursor to NAD+ so it would be more efficient than NR
NAD and NMN must first undergo extracellular degradation to nicotinamide, nicotinic acid, or nicotinamide riboside in order to be taken up into cells (Felici et al., 2013; Ratajczak et al., 2016
Chris Masterjohn, Phd, on the Peter Attia podcast, agrees that oral NMN is a waste, and at best just gets turned into NR:
"I would bet money that oral NMN is not absorbed intact, and that’s because NMN has a charged phosphate group on it, and generally charged phosphates cannot cross cells, and so they are hydrolyzed. And even if it were true that there were transporters in the intestine that could take up NMN intact, it probably still would not be absorbed intact because the phosphatases in the small intestine cleave the phosphates off of everything that you are eat non-specifically, because generally phosphates can’t cross cells. So I doubt that the NMN gets in there intact, and if anything maybe it gets cleaved to NR, and the NR does. I believe the NR gets there intact because that’s what the Rabinowitz group’s paper showed."
Any further progressIt was about 10 days in that I noticed reduced shedding. 4 weeks now and I'm noticing some regrowth starting to occur
I didn't notice major shedding.What about your shedding since your start of SMI ?
NMN might be something I take in the future. I took NR for a few months and didn't notice any difference. I then read that it might be better to boost NAD with some of the stuff I'm taking if you're a bit younger.Why not just take NMN in that case?
A little over three weeks.How long have you been on SMI for?
Right I know that, but I was saying that it hasn't been proven NR is more effective as there are pathways for NMN to enter cells directly: https://www.nature.com/articles/s42255-018-0009-4#change-historyThis would make NR more efficient, and it's also cheaper.
NMN v. NR -- Which Is More Effective?
NR and NMN are chemically very similar, but they don't cost the same, and some studies show diifferent effectswww.right-of-assembly.org
when you take oral SMI, do you take it by itself without mixing it with anything? also, how are you measuring it? i bought a scale off amazon, but it's completely useless.Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.
Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 60mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg
Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 60mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)
- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week
View attachment 164863
View attachment 164864
Ok, but the study I just posted contradicts that. "NMN must first undergo extracellular degradation to nicotinamide, nicotinic acid, or nicotinamide riboside in order to be taken up into cells". I don't understand how you say you know that and then you go on to say the opposite. Perhaps you missed that part. Maybe this is not accurate, but if it is then NMN is not nearly as good as NR so you'd be taking a big risk taking NMN whereas you know NR works. Further studies have to be conducted on humans to determine which of these studies is correct. What we can say for sure is that NR works, so I see no reason to risk taking NMN instead. Even in best case scenario it won't work much better since NR is very good at converting to NAD. As of now there are more studies showing that NR works in humans than NMN. This could change, and NMN could be slightly better. I assume NMM popularity comes from David Sinclair, but even he admits that NR might be better, they need more study to find out. For now I will stick with the more stable molecule.Right I know that, but I was saying that it hasn't been proven NR is more effective as there are pathways for NMN to enter cells directly: https://www.nature.com/articles/s42255-018-0009-4#change-history