Prolactin "minitherapy" with SMI-1 (novel protocol for lowering prolactin locally)

[FollicleGuardian]

void

 

[Zon Ama]

Damn bro, this sounds awesome! How many people will follow this protocol, are you going to share your results/experiences?

btw good luck and hopefully there are no serious side effects!!

 

[FollicleGuardian]

Damn bro, this sounds awesome! How many people will follow this protocol, are you going to share your results/experiences?

Not sure yet yes

 

[Will Be an Egg in 5 years]

Is there any other to reduce prolaction levels in our body?

 

[Roeysdomi]

Cookie men , great job.

 

[FollicleGuardian]

Thanks!

 

[1919]

What are the potential side effects of your proposed treatment?

 

[1919]

It won't kill you.

My bad, didnt see the part about using low volume. Really cool stuff.

 

[1919]

«Although PRL has been shown to be involved in a wide spectrum of biological functions, including immune responses, metabolic functions or bone formation / turn-over (5), it is viewed as a modulator, rather than a key regulator of these functions. Therefore, no major problem of toxicity is anticipated, although we should remain vigilant since many of the actions attributed to PRL have been identified and studied using animal models. Reproductive performance appears to be the physiological function that is the most sensitive to abnormal PRL levels, since both hyper- and hypoprolactinemia lead to fertility problems. In the current state of the art, no other major function should be significantly altered following administration of PRLR antagonists.»

Amazing find, you are a genius!

 

[Pls_NW-1]

Yes treat one area at the time rather than going nuclear. Wake up dormant stem cells part for part in the scalp.

Not gonna lie. You will develop most likely within this decade a treatment cure in your basement before any other company does so in the next 3-4 decades lol.

 

[Armando Jose]

Which molecule? This one?

(PDF) Small Molecule Inhibitors of the Prolactin Receptor in Breast Cancer

PDF | Breast cancer is both a common and a significant health concern for women across the globe. Emerging evidence suggests that the prolactin (PRL)... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

BTW your approach is good

 

[Gegen]

There should be zero side effects from this except maybe a headache for some people. Using it topically the dose won't be nearly high enough to do much systemically, and shutting down prolactin is pretty safe to begin with in men. That's assuming we'll be able to use it topically. I don't even know the solubility of this molecule.

Quoted from the molecule's patent :
"Dispersions of the SMI compounds according to the invention may also be prepared in glycerol, liquid polyethylene glycols, oils, and mixtures thereof. Under ordinary conditions of storage and use, pharmaceutical preparations may contain a preservative to prevent the growth of microorganisms.Pharmaceutical compositions suitable for injection include: sterile aqueous solutions (where water soluble), or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. Ideally, the composition is stable under the conditions of manufacture and storage and may include a preservative to stabilise the composition against the contaminating action of microorganisms such as bacteria and fungi. "

https://patents.google.com/patent/WO2018049092A1/en

But yes, solubility is very unclear.

 

[Gegen]

Which molecule? This one?

(PDF) Small Molecule Inhibitors of the Prolactin Receptor in Breast Cancer

PDF | Breast cancer is both a common and a significant health concern for women across the globe. Emerging evidence suggests that the prolactin (PRL)... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

BTW your approach is good

That's it.

 

[trialAcc]

I'll PM you regardless, but are you guys planning any self reported toxicology screening? Do you know what areas to monitor?

 

[FollicleGuardian]

Not gonna lie. You will develop most likely within this decade a treatment cure in your basement before any other company does so in the next 3-4 decades lol.

Hahah lmao made my day

 

[FollicleGuardian]

Amazing find, you are a genius!

Thanks man!

 

[eeyore]

What WNT-agonist have members of this forum been testing?

 

[eeyore]

KY19382 is what all the cool kids are using now.

Aren't people still trying to get the group buy going for that?

 

[FollicleGuardian]

Slow down cookie man, you are finding new treatments faster then anyone can actually use them.

Hahah

 

[Dimitri001]

Hi everyone. Lot of talk about prolactin these days. But it is just so freaking promising. Prolactin might be responsible for keeping stem cells in a dormant state (credit to @pegasus2 and @ElToso for this find about dormancy). Which might be the reason why it is so hard to get regrowth even with a really potent WNT-agonist.

So let me introduce what I call "Prolactin Minitherapy". This is a novel way to potently inhibit prolactin locally in the hair follicle. This minitherapy protocol suggests using a really high concentrated topical with a prolactin antagonist. But use a low volume of it. In other words a strong solution of PRL inhibitor, on a small area. Treatment in the area continously for 3 months. To "wake up" the dormant stem cells, and then switch to another small area. Working through the whole scalp eventually.

By keeping the % high, but total volume low we minimize the risk for side effects if it goes systemic. The effects of BAY were lasting, so in theory it will be with this protocol as well. The high % of PRL inhibitor will absolutely flood the cells in the treated area with these antagonists, the intracellular level will be high. This concentration will be needed in order to compete with prolactin for the PL receptor. This is the same mechanism as CB uses, they leverage the sheer volume, and don't focus on pure binding affinity. Not that CB is an amazing treatment, but to be so weak in terms of binding affinity, it tells us this method work.

We have found a SMI (small molecule inhibitor) for prolactin. We have a discord you can join. PM me for invite.

This might be the key for regrowth we have been missing for a long time!

Once the cells have been roused in one area, how long should they theoretically stay functional before retreatment would be necessary? I assume we wouldn't expect the same kind of continuous regrowth post-treatment as with the antibody?