Prolactin "minitherapy" with SMI-1 (novel protocol for lowering prolactin locally)

[Dimitri001]

Are there any in vivo studies of SMI-6 (or any other molecule with same mechanism of action) for breast cancer or any other indication?

 

[Throwaway94]

Are there any in vivo studies of SMI-6 (or any other molecule with same mechanism of action) for breast cancer or any other indication?

Only in mice

 

[fashy]

Somewhere in this thread Pegasus mentioned that he has written why HMI is better than RU even though both achieved similiar results in macaques but I cannot find any such posts in the back pages of this thread.

Can anyone explain the difference between the two?

 

[LouisSarkozy]

The increase in hair counts in the RU trial was mostly vellus hairs. The increase in the BAY trial was terminal hairs.

Edit: https://www.hairlosstalk.com/intera...owering-prolactin-locally.131564/post-1955085

man when do you think we will see human trial for bay? i'm desperate

 

[5minutesbeforemiracle]

man when do you think we will see human trial for bay? i'm desperate

Not desperate enough to read through the threads though (summer 2021 was the initial projection, looks like it'll probably happen next year).

 

[Nehel]

We should see results next year even if they fall far behind schedule

Or never.... just like SM04554

 

[fashy]

I feel like this is almost impossible not to work on us at least as good as finasteride is working and probably better than that. The question then would be if there would be any unwanted side effects be it serious or mild. Samumed never had even an ounce of this drug's potential.

 

[Ollie]

I feel like this is almost impossible not to work on us at least as good as finasteride is working and probably better than that. The question then would be if there would be any unwanted side effects be it serious or mild. Samumed never had even an ounce of this drug's potential.

Any side effects of this are an absolute benefit. Prolactin in men is absolutely trash. ED, low libido, gyno etc..

 

[LouisSarkozy]

We should see results next year even if they fall far behind schedule

so only one more year to know if we're saved for good thanks for the answer

 

[Micky_007]

HMI has made it clear that the main reason they wanted the drug rights from Bayer was for the indication of Androgenetic Alopecia. They also confirmed Androgenetic Alopecia ph2 trials enrolling this year in Australia. It won't take 6 months to enroll patients with Androgenetic Alopecia. There are millions of bald men for them to choose from. It's not like trying to find a cancer patient that is willing to take a risk

Can you provide the link for where Hope Medicine "confirmed Androgenetic Alopecia phase 2 trials enrolling this year in Australia" because I can't find anything on the internet stating that

 

[Numerous_Bet_3027]

Can you provide the link for where Hope Medicine "confirmed Androgenetic Alopecia phase 2 trials enrolling this year in Australia" because I can't find anything on the internet stating that

This isn't available anymore, they have changed the article and removed the part that they will start this Summer. It was here:

和其瑞医药联合创始人肖瑞平：医药强国，吾辈使命 - 创新人才 - 南京生物医药谷

· 和其瑞医药有限公司联合创始人、董事长兼首席执行官；· 北京大学讲席教授，北大分子医学研究所所长；· 《新英格兰医学期刊》副主编

www.njbpv.cn

Now the only confirmation we have from them is that phase 2 will start for multiple indications:
"HMI-115, a prolactin receptor antibody, has passed animal experiments and phase I clinical human studies, and will enter phase II trials in multiple indications in 2021."

Hope Medicine Inc. Announced Dr. Henri Nico Doods as President and Head of Research & Clinical Development - PR Newswire APAC

SHANGHAI, Dec. 14, 2020 /PRNewswire/ -- Hope Medicine Inc. Announced Dr. Henri Nico Doods as President and Head of Research & Clinical Development

en.prnasia.com

 

[Micky_007]

This isn't available anymore, they have changed the article and removed the part that they will start this Summer. It was here:

和其瑞医药联合创始人肖瑞平：医药强国，吾辈使命 - 创新人才 - 南京生物医药谷

· 和其瑞医药有限公司联合创始人、董事长兼首席执行官；· 北京大学讲席教授，北大分子医学研究所所长；· 《新英格兰医学期刊》副主编

www.njbpv.cn

Now the only confirmation we have from them is that phase 2 will start for multiple indications:
"HMI-115, a prolactin receptor antibody, has passed animal experiments and phase I clinical human studies, and will enter phase II trials in multiple indications in 2021."

Hope Medicine Inc. Announced Dr. Henri Nico Doods as President and Head of Research & Clinical Development - PR Newswire APAC

SHANGHAI, Dec. 14, 2020 /PRNewswire/ -- Hope Medicine Inc. Announced Dr. Henri Nico Doods as President and Head of Research & Clinical Development

en.prnasia.com

Thanks. That's unfortunate for us. Have they even done a Phase 1 in humans for Androgenetic Alopecia, since they were talking about Phase 2?

 

[RolfLeeBuckler]

Thanks. That's unfortunate for us. Have they even done a Phase 1 in humans for Androgenetic Alopecia, since they were talking about Phase 2?

Yes they Did Phase 1 in humans in which safety was confirmed

 

[Micky_007]

Yes they Did Phase 1 in humans in which safety was confirmed

I didn't know the Phase 1 was conducted already for Androgenetic Alopecia*.. Can you link the study?

 

[Tom4362]

I didn't know the Phase 1 was conducted already for Androgenetic Alopecia*.. Can you link the study?

It wasn't for Androgenetic Alopecia, but for women that have Endometriosis

 

[Throwaway94]

I didn't know the Phase 1 was conducted already for Androgenetic Alopecia*.. Can you link the study?

There's no such thing as a phase 1 specifically for Androgenetic Alopecia. There's phase 1 for the drug itself which is something of a dose / safety / tolerability trial rather than a measure of response.

 

[trialAcc]

I didn't know the Phase 1 was conducted already for Androgenetic Alopecia*.. Can you link the study?

Phase 1 just measures safety, they don't look at results. For Kintor's topical AA/degrader they applied it on people's backs for phase 1.

Only issue I have with this phase 1 is that without males in the study, there could be surprises in the phase 2 when it's conducted on males. Otherwise the HMI drug seems pretty safe imo.

 

[Micky_007]

Phase 1 just measures safety, they don't look at results. For Kintor's topical AA/degrader they applied it on people's backs for phase 1.

Only issue I have with this phase 1 is that without males in the study, there could be surprises in the phase 2 when it's conducted on males. Otherwise the HMI drug seems pretty safe imo.

Exactly the reason I'm also concerned about the safety for males since they weren't in the safety study.

 

[trialAcc]

Exactly the reason I'm also concerned about the safety for males since they weren't in the safety study.

I wouldn't be too concerned, there will be more then enough safety data from phase 2.

 

[RolfLeeBuckler]

I wouldn't be too concerned, there will be more then enough safety data from phase 2.

Can you pleite gute us the link about the Fact that only women participated in the Trial?

How is it passable that they can start a Phase 2 trial in men without even doing Phase 1 for them?
Which dangerous Effects could only happen in men but not in women in Phase 2?