Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Exactly. Especially the fact that 5AR-type 2 deficient individuals are protected from androgenic hairloss is striking. Of course, 'ordinary' people without this deficiency will never be able to complete annihilate DHT, but in theory should be able to come pretty close with topical Dutasteride. Then, preventing the leftover DHT from binding with a good AR antagonist should seal the deal. The main difficulty does not lie in maintenance though, but in regrowth. Entirely different beast. However, I do suspect that years of consecutive blocking of scalp androgenic activity should eventually yield some kind of regrowth (reversing fibrosis takes time - a lot of time) - mainly based on MtF transgender individuals that eventually seem to regrow at least some hair.
My advice to anyone visiting this forum is still the same. HRT is not a smart decision if you're not trans, and you will very likely regret it. Unlike for instance the thyroid axis, the HPT axis is not resilient, and odds are you will be left hypogonadic after quitting. It will be a histologically different kind of hypogonadism than, for instance, anabolic steroids users experience (which is already problematic and the main subject on many steroid-based fora), since E2 is actually testicotoxic, whereas T is not. Hence, when you decide HRT is not for you, you may be left with a permanently attenuated testicular functioning, forcing you to resort to TRT for the rest of your life to feel like before. If you want to use E2 semi-responsibly use it topically in the right amounts (a few micrograms per mL - milligrams are HRT dosages and should be avoided).
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The legend returns...
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@dani500 you said you tried cpa with e2 and dutasteride with no results.. that is surprizing how long did you stay on that regimen??Also can't wait for you to finish your gyno surgery (i wish the best results) to update us.My gyno atm is a small hard lump to the size of a small eye ball behind both nipples not visible but it is kind of painful and when hot it gives me puffy right nipple!!I will get surgery i guess next month! Been on bica 60 days and this is the only visible change..If we exclude the gyno dutasteride gives me way more sides than bica to be honest! Maybe i can handle all that meds because i am on Anafranil and Abilify aswell.I hate dutasteride but i must adhere and keep taking for ever!! I take finasteride aswell because it is cheap and why not??My body fat is 8%-9%,i lost muscle on dutasteride about 4 kgs, and a lot more side effects from duta alone!Also this friday i got my self some custom made minoxidil pills from a pharmacy 5mg and i will stop drinking the liquid!
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Some, including myself, will disagree with you. I have been on HRT for 8 months now and I have no regrets. And I won’t regret even if I have to use HRT, because nothing disfigures like baldness
A year ago, I would have said the same thing as you, but when you rapidly turn into a bald freak, you better understand what to choose in this shitty situation.
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Have you tried Dutasteride + Minoxidil or Bicalutamide + Dutasteride? I'm wondering how important bicalutamide is in your regimen. Because at the dosage of 100mg with Finasteride, I continued to go bald as if I hadn't done anything.
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You started well, but ended up with complete BDD bullshit that I've already had to answer. Probably, in your world, any person who takes their appearance seriously and avoids turning into a ugly orc suffers from mental illness, and even the one who puts on braces or takes care of the skin of the face is sick
Regarding the study: as I understand it, the study of Flutamide was conducted on patients with already stabilized baldness. It changes a lot, doesn't it? The study of Bicalutamide, on the other hand, had a short period, during which it is impossible to judge whether baldness is stabilized. But I admit that it works well for women. But since it does not work for men from this forum, I am not particularly interested in this.
It's a shame that Bicalutamide didn't help most people on this forum. I don’t know how effective it is in women, but among men, only a few responded to it
Dutasteride, according to studies, is good for men. But firstly, baldness has different aggressiveness, and there are practically no young guys in the studies. And secondly, I advise you to look at the photo of any finasteride and Duta research: freezing baldness at a large stage is considered a success. If they started taking drugs immediately at the onset of baldness, for example, on Norwood 1, the results would be more interesting. I do not think that stopping hair loss on Norwood 2-4 is a good result.
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The reason I think bica works for women and not men is that in men it raises T levels but effectively prevents T from binding, so that excess likely converts to DHT which has far more affinity for androgen receptors than bica does. So imo bica should never be used without being in conjunction with a 5ari (or e2 which will prevent much of the increase in T due to hpa axis)
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Well I think T might also cause hairloss in people whose receptors are suuuper sensitive. But T has a fraction of the binding affinity that dht does, so doesn't pose nearly the same threat. But that might be to blame in those who get increased hairloss after introducing dutasteride
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Won’t a significant portion of that T aromatize in women?
I used to lean towards this theory but when you consider that pseudohermaphrodites (lacking 5AR) never lose hair it makes me believe that the dutasteride hair loss could have to do with upregulation. But perhaps it is a combination. Hmm…
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T can be aromatized to E in either sex, and bica generally increases E lvls in cis men taking bica alone. But that increase in T won't occur in cis women (or trans women using E due to its antigonadotropin effect causing negative feedback on the hpg axis).
As for T causing hairloss, I'm honestly not sure. Your point about 5ar deficient individuals being immune to hairloss is valid and made me believe at one time dht was the only potential cause. But I'm really not sure one way or another. I suppose dutasteride could be increasing receptor sensitivity of starved receptors upregulating to such a degree that even a minor amount of dht is potent enough to decimate hair in such unlucky individuals. But who knows ultimately
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This assertion is not supported by anything. It's nothing more than your imagination. In Russia, some say that one who has not served in the army is not a man. You are spouting similar nonsense, which is based on nothing. I don't think a man is defined by his fertility and erection lol
And I don't understand fertility concerns from those who aren't even planning to have children. In my opinion, such contradictory is a sign of dementia.
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Hey... How is ur hair?.. Treatment working?
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Yes, I have terminal hair along the Norwood 0 growth line. But it is very thin. I'm waiting for the thickening.
Ur regime?.. I'm currently on 100 mg spironolactone and 4mg estradiol sublingual...
But since starting hrt... My hair has become brittle and wirey... Is it due to hormonal fluctuations?
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Click on "My regimen"
I did not have increased fragility
Ok ... I don't know y my hair turned fragile overnight...
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But you will be ready for the balkan summer!!did your doctor say after how many days do you hit the gym??Also can you use via gra together with oral minoxidil?
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Happy for all of those who succeed to solve the problem, hope that soon I will be among you.