Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Max summary of Metformin/AKG. AMPK and TORm receptor
I was going to create a topic on this, but we already posted everything right here, this is what I managed to gather with my knowledge and my summary
www.ncbi.nlm.nih.gov
"""A recent study has shown the potential usefulness of AMPK treatment in preserving bone mass as well as lowering bone turnover in post-menopausal women (Tocaj et al., 2003). Results suggest a link between enteral AKG/AMPK and an increase in estrogen levels. """
In my opnion maybe higher i little or regulates receptor(AR or ER) I have already posted some studies in other posts where the AMPK pathway regulates AR receptors , wathever maybe AMPK pathway modulates estrogen levels.
It appears that high levels of AMPK response result in high levels of estrogens are somehow still unclear how levels of estrogens can higher.
Explains the effect of metformin on acne, on hinsurtism, skin's diseases , In addition to the effects of AMPK / AKG stimulation , estrogen being an "anti androgen" by definition and studies pointing to this side explain a lot its off-label therapeutic effect.
High levels of AMPK RESPONSE will compel your follicles to enter the anagen phase
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
www.sciencedirect.com
It has a direct effect on the hair follicle in several different paths .
It can be an unprecedented therapeutic drug for your capillary and skin health, in a way you never dreamed of, I saw a lot of things that scared me with results, but it's not all flowers, is it?
This pathway interferes with glutamine metabolism
The AMPK pathway increases the availability of glutamine, so to speak.
Glutamine has great effects on the body, macrophages and other cells of our immune and muscular system.
However, in the brain it can have adverse effects on (swelling of astrocytes, defects in neuronal communication) this is how severe liver conditions develop .
Glutamine is metabolized to ammonia, this is too toxic for the kidneys and liver , besides everything and in addition we can enter an eternal cycle of ammonia to hyperstimulate this pathway
www.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
And stimulate the catabolism acids BCAA's; valine, leucine and isoleucine in skeletal muscle .
The post will be gigantic if I go on explaining it, but I can already tell, I just say that stimulating the AMPK route can be wonderful for skin and hair, but this is the contract, this in the long term 10 years for example can evolve something bad .
In other words, make your choice via AMPK worth it or not?
I was going to create a topic on this, but we already posted everything right here, this is what I managed to gather with my knowledge and my summary
Alpha-Ketoglutarate: Physiological Functions and Applications - PMC
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits ...
www.ncbi.nlm.nih.gov
"""A recent study has shown the potential usefulness of AMPK treatment in preserving bone mass as well as lowering bone turnover in post-menopausal women (Tocaj et al., 2003). Results suggest a link between enteral AKG/AMPK and an increase in estrogen levels. """
In my opnion maybe higher i little or regulates receptor(AR or ER) I have already posted some studies in other posts where the AMPK pathway regulates AR receptors , wathever maybe AMPK pathway modulates estrogen levels.
It appears that high levels of AMPK response result in high levels of estrogens are somehow still unclear how levels of estrogens can higher.
Explains the effect of metformin on acne, on hinsurtism, skin's diseases , In addition to the effects of AMPK / AKG stimulation , estrogen being an "anti androgen" by definition and studies pointing to this side explain a lot its off-label therapeutic effect.
High levels of AMPK RESPONSE will compel your follicles to enter the anagen phase
Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles - PubMed
Mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and survival. There is limited evidence that mTOR influences hair follicles (HFs), which undergo cycles of quiescence (telogen), growth (anagen) and regression (catagen). We sought to investigate whether mTOR, in...
pubmed.ncbi.nlm.nih.gov
Stimulation of Hair Growth by Small Molecules that Activate Autophagy - PubMed
Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions worldwide, but methods that can be used to regrow hair are lacking. We report that quiescent (telogen) hair follicles can be stimulated...
pubmed.ncbi.nlm.nih.gov
mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration - PubMed
Hair follicles (HFs) undergo cycles of degeneration (catagen), rest (telogen), and regeneration (anagen) phases. Anagen begins when the hair follicle stem cells (HFSCs) obtain sufficient activation cues to overcome suppressive signals, mainly the BMP pathway, from their niche cells. Here, we...
pubmed.ncbi.nlm.nih.gov
Stimulation of Hair Growth by Small Molecules that Activate Autophagy
Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects …
It has a direct effect on the hair follicle in several different paths .
It can be an unprecedented therapeutic drug for your capillary and skin health, in a way you never dreamed of, I saw a lot of things that scared me with results, but it's not all flowers, is it?
This pathway interferes with glutamine metabolism
The AMPK pathway increases the availability of glutamine, so to speak.
Glutamine has great effects on the body, macrophages and other cells of our immune and muscular system.
However, in the brain it can have adverse effects on (swelling of astrocytes, defects in neuronal communication) this is how severe liver conditions develop .
Glutamine is metabolized to ammonia, this is too toxic for the kidneys and liver , besides everything and in addition we can enter an eternal cycle of ammonia to hyperstimulate this pathway
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy–therapeutic perspectives - PMC
There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in ...
www.ncbi.nlm.nih.gov
AMPK Activation Affects Glutamate Metabolism in Astrocytes - PubMed
Mammalian AMP-activated protein kinase (AMPK) functions as a metabolic switch. It is composed of 3 different subunits and its activation depends on phosphorylation of a threonine residue (Thr172) in the α-subunit. This phosphorylation can be brought about by 5-aminoimidazole-4-carboxamide...
pubmed.ncbi.nlm.nih.gov
And stimulate the catabolism acids BCAA's; valine, leucine and isoleucine in skeletal muscle .
The post will be gigantic if I go on explaining it, but I can already tell, I just say that stimulating the AMPK route can be wonderful for skin and hair, but this is the contract, this in the long term 10 years for example can evolve something bad .
In other words, make your choice via AMPK worth it or not?
Last edited:
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Do you have hair right?
Your hair is very beautiful, that's why I tell you, go live, live life, get out, meet cool people who will like you, create relationships, since you've achieved your results, you have no reason to stay here.
Don't be suggesting progesterone to everyone like that, think that some users may read this and take it seriously, and it may not help you at all, what works for you may end someone else's life.
You only make affirmations.
Explain and prove your hypothesis with data to convince us, we don't know you, we don't know if you really used progesterone in your treatment, I want you to understand that we're trying to help each other here and what's good for me may not be for someone else, so explain to me how it works, share articles, results solid and reliable and so we can discuss something.
Peace my friend
I don’t think so. He got a full regrowth, there is no point in making the regime stronger. On the contrary, it made sense to reduce the dosage to 75-100mg. 150mg is too much
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Taking Bicalutamide, Dutasteride,... for life, regrowing and keeping hair sounds all tooo good... that it can't be real. -> risking health etc.
I wonder how long you can stay on such treatments.
Will we be able to sustain till the "CURE" comes out!? Lol
I wonder how long you can stay on such treatments.
Will we be able to sustain till the "CURE" comes out!? Lol
- Reaction score
- 1,104
I went today to the endocrinology, results in 2 months, I might be able to start Bicalutamide (100mg) in 3-5 months. If not, I will probably source it through dark web, but I am pretty sure I will be able to get it if I present the science and the effect of it, and why I NEED it.
Bicalutamide is the only medicine. We can wait for developments in the field of hair transplant for those whose follicles have died, but my follicles are alive, so I want to keep Norwood 0. I need hair thickening, Bicalutamide can give it.
Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia - PubMed
Androgenic alopecia (Androgenetic Alopecia), also known as male pattern baldness, is one of the most common hair loss diseases worldwide. The main treatments of Androgenetic Alopecia include hair transplant surgery, oral medicines, and LDL laser irradiation, although no treatment to date can fully cure this disease. Animal models...
pubmed.ncbi.nlm.nih.gov
Bicalutamide Treats Androgenetic Alopecia in Mice
- Reaction score
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My god thank you!!! Cant wait collecting all these studies and spamming my Doctor. He can't deny lmaoDihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia - PubMed
Androgenic alopecia (Androgenetic Alopecia), also known as male pattern baldness, is one of the most common hair loss diseases worldwide. The main treatments of Androgenetic Alopecia include hair transplant surgery, oral medicines, and LDL laser irradiation, although no treatment to date can fully cure this disease. Animal models...
Bicalutamide Treats Androgenetic Alopecia in Mice
Prepare a portfolio lol
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As of today I'm giving the estrogel a rest, no conventional sides, no gyno or anything typical save for the fact that I feel that my applying it every day has gone somewhat systemic and I'm getting issues with fatigue and I don't like how dry my skin feels. I don't know if it's because of low test or the min, but if min is interfering with my androgen receptors on top of whatever the estrogel was doing, I'm going to have to reconfigure my approach.
I feel this has a lot to do with my taking minoxidil as well, because there is some research that implies that on top of the estrogen minoxidil may actually interfere with androgen receptor activity as well.
So I'm transitioning entirely to minoxidil, and tonight I'm getting the finasteride and I'm going to make up a batch of dilute 2.5% minoxidil and 1mg finasteride solution and start with that. I am not playing around with finasteride, that sh*t is going to start off in very low concentrations. I am not going to put myself in the same situation I did before with taking it orally.
I feel like the growth stimulatory effects of minoxidil are preferable to the estrogen at this point, there is a far greater chance of my getting my hair back and being able to cut weight and be lean again if I can get a good ratio of administered minoxidil and topical finasteride going. Minoxidil has done far more for improving blood flow in my body even if I can't handle 5% for more than six days at one application per day.
Estrogen for me will always have some undesirable sides if I rely on it as my mainstay, if whatever is going on stabilizes, I will return to using the estrogel albeit in a considerably more dilute solution and applied less frequently.
www.ncbi.nlm.nih.gov
If what is written in this abstract is true, then it would explain why minoxidil works for men who have Androgenetic Alopecia without the use of any other androgenic antagonists, for some people it simply may be enough.
I feel this has a lot to do with my taking minoxidil as well, because there is some research that implies that on top of the estrogen minoxidil may actually interfere with androgen receptor activity as well.
So I'm transitioning entirely to minoxidil, and tonight I'm getting the finasteride and I'm going to make up a batch of dilute 2.5% minoxidil and 1mg finasteride solution and start with that. I am not playing around with finasteride, that sh*t is going to start off in very low concentrations. I am not going to put myself in the same situation I did before with taking it orally.
I feel like the growth stimulatory effects of minoxidil are preferable to the estrogen at this point, there is a far greater chance of my getting my hair back and being able to cut weight and be lean again if I can get a good ratio of administered minoxidil and topical finasteride going. Minoxidil has done far more for improving blood flow in my body even if I can't handle 5% for more than six days at one application per day.
Estrogen for me will always have some undesirable sides if I rely on it as my mainstay, if whatever is going on stabilizes, I will return to using the estrogel albeit in a considerably more dilute solution and applied less frequently.
Minoxidil may suppress androgen receptor-related functions - PMC
Although minoxidil has been used for more than two decades to treat androgenetic alopecia (Androgenetic Alopecia), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may ...
www.ncbi.nlm.nih.gov
If what is written in this abstract is true, then it would explain why minoxidil works for men who have Androgenetic Alopecia without the use of any other androgenic antagonists, for some people it simply may be enough.
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If what is true about tha
That's a lot of excellent information, it certainly serves as a warning against the very large therapeutic dosages that are prescribed for diabetes.
Note to self, supplement with L-Ornithine when taking low dose metformin.
Also note to self, keep an eye on blood urea levels, (L-Ornithine lowers blood ammonia and in turn increases the production of urea instead)
examine.com
Max summary of Metformin/AKG. AMPK and TORm receptor
I was going to create a topic on this, but we already posted everything right here, this is what I managed to gather with my knowledge and my summary
Alpha-Ketoglutarate: Physiological Functions and Applications - PMC
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits ...
"""A recent study has shown the potential usefulness of AMPK treatment in preserving bone mass as well as lowering bone turnover in post-menopausal women (Tocaj et al., 2003). Results suggest a link between enteral AKG/AMPK and an increase in estrogen levels. """
In my opnion maybe higher i little or regulates receptor(AR or ER) I have already posted some studies in other posts where the AMPK pathway regulates AR receptors , wathever maybe AMPK pathway modulates estrogen levels.
It appears that high levels of AMPK response result in high levels of estrogens are somehow still unclear how levels of estrogens can higher.
Explains the effect of metformin on acne, on hinsurtism, skin's diseases , In addition to the effects of AMPK / AKG stimulation , estrogen being an "anti androgen" by definition and studies pointing to this side explain a lot its off-label therapeutic effect.
High levels of AMPK RESPONSE will compel your follicles to enter the anagen phase
Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles - PubMed
Mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and survival. There is limited evidence that mTOR influences hair follicles (HFs), which undergo cycles of quiescence (telogen), growth (anagen) and regression (catagen). We sought to investigate whether mTOR, in...
Stimulation of Hair Growth by Small Molecules that Activate Autophagy - PubMed
Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions worldwide, but methods that can be used to regrow hair are lacking. We report that quiescent (telogen) hair follicles can be stimulated...
mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration - PubMed
Hair follicles (HFs) undergo cycles of degeneration (catagen), rest (telogen), and regeneration (anagen) phases. Anagen begins when the hair follicle stem cells (HFSCs) obtain sufficient activation cues to overcome suppressive signals, mainly the BMP pathway, from their niche cells. Here, we...
Stimulation of Hair Growth by Small Molecules that Activate Autophagy
Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects …
It has a direct effect on the hair follicle in several different paths .
It can be an unprecedented therapeutic drug for your capillary and skin health, in a way you never dreamed of, I saw a lot of things that scared me with results, but it's not all flowers, is it?
This pathway interferes with glutamine metabolism
The AMPK pathway increases the availability of glutamine, so to speak.
Glutamine has great effects on the body, macrophages and other cells of our immune and muscular system.
However, in the brain it can have adverse effects on (swelling of astrocytes, defects in neuronal communication) this is how severe liver conditions develop .
Glutamine is metabolized to ammonia, this is too toxic for the kidneys and liver , besides everything and in addition we can enter an eternal cycle of ammonia to hyperstimulate this pathway
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy–therapeutic perspectives - PMC
There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in ...
AMPK Activation Affects Glutamate Metabolism in Astrocytes - PubMed
Mammalian AMP-activated protein kinase (AMPK) functions as a metabolic switch. It is composed of 3 different subunits and its activation depends on phosphorylation of a threonine residue (Thr172) in the α-subunit. This phosphorylation can be brought about by 5-aminoimidazole-4-carboxamide...
And stimulate the catabolism acids BCAA's; valine, leucine and isoleucine in skeletal muscle .
The post will be gigantic if I go on explaining it, but I can already tell, I just say that stimulating the AMPK route can be wonderful for skin and hair, but this is the contract, this in the long term 10 years for example can evolve something bad .
In other words, make your choice via AMPK worth it or not?
That's a lot of excellent information, it certainly serves as a warning against the very large therapeutic dosages that are prescribed for diabetes.
Note to self, supplement with L-Ornithine when taking low dose metformin.
Also note to self, keep an eye on blood urea levels, (L-Ornithine lowers blood ammonia and in turn increases the production of urea instead)
Ornithine benefits, dosage, and side effects
Examine simplifies nutrition and supplementation — through meticulous analysis of the latest scientific research — to help answer your questions on how to be healthier.
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Estrogen and progesterone antagonize one another.
Progesterone doesn't so much feminize like estrogen, it more interferes with testosterone and DHT passively and exerts its own effect. What I will say is, I have been using topical estrogen in an alcohol gel suspension on my scalp for a few weeks now, and I have had absolutely zero overtly feminizing effects, no gyno at all, just a bit of weight gain.
I have been prescribed pharmacy grade progesterone before, and I had to stop taking it because around a week of taking it I started feeling a definite tingling and soreness around my nipple area, which became mildly enlarged until I realized it was the progesterone doing it and discontinued.
Progesterone is not a strong hormone for growing hair the way estrogen does, it absolutely can maintain hair however. It won't hurt it, because progesterone interferes with DHT and Testosterone, but it won't stimulate the kind of crazy regrowth we've seen from people like bridgeburn.
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I thought that it would make sense (maybe not as well) if someone would use progesterone while using Bi-Estro or Estrogel, just for the idea of the resensitization for the estrogen receptors (if it's possible to happen), to keep the balance between progesterone and estradiol. So, the whole logic would be: Applying, maybe once a week, or 2-4 times per month progesterone as well, so you won't "overload" the estrogen receptors and keep the balance with the antagonizing effects of progesterone. I read that progesterone to estradiol ratio is very important, and these two hormones must be kept in balance. I guess that's why many estrogens come with progestogens as well (balance). Topical application is a different thing but still something to consider (I mainly talk for when it comes to topical application though). Another problem with progesterone, apart from the antagonism to Estradiol, is the specific query: "What if is capable to enable the backdoor pathway of DHT through the 17-OHP?" wouldn't be a problem as well? I keep in my mind these thoughts about Progesterone. Any opinion is appreciated. Thank you.
I recommend that you start at 75mg and increase as needed. I have suspicions that 100mg and above are unnecessarily large dosages. I'm not sure about this yet, but I'm guessing. Either way, it will stop the progression, so you won't lose anything if you try
It is advisable to avoid high dosages of Bicalutamide and remember that these are not vitamins from Iherb
PSA values are reduced even more when used together with Finasteride Bicalutamide. This will exceed 90%, which should be enough.
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ClinicalKey
www.clinicalkey.com
""By day 4, control HFs and HFs treated with DHT plus bicalutamide were still in anagen, whereas HFs treated with DHT alone had entered catagen phase. Hair length recording revealed that DHT inhibited hair growth and that this effect was partly reversed by bicalutamide""
Very good @Almas article, I had never seen anything from specific bicalutamide treating androgenic alopecia in that sense DHT
Only studies in women
Good article.