Breezula Positive Phase 2 Result For Treat Androgenetic Alopecia

[PeggyPeterson]

and since many teens get acne cassiopeia seems to trust that it will not go systemic or they are going to get countless lawsuits

If you read that detailed document I sent, it does say that 0.1 to 0.8 nanograms of the metabolite cortexalone does go systematic. Now i’m Not a subject matter expert here, so I would be interested to know if cortexalone in small amounts can cause noteworthy side effects???

Winlevi met its endpoints in the phase 3 study 6 months ago. Anyone who understands how clinical trials work care to explain the likelihood of a successful phase 3 trial going into market? The next step is apparently an NDA application. How often do these application get rejected?

 

[Yepesyellow]

Wasn’t the issue with this one that no one could replicate the vehicle?

Yes, that is what I understand also. A few people have tried the active chemical component to unimpressive effect, however without any competent knowledge of the vehicle.

 

[Btg]

If you read that detailed document I sent, it does say that 0.1 to 0.8 nanograms of the metabolite cortexalone does go systematic. Now i’m Not a subject matter expert here, so I would be interested to know if cortexalone in small amounts can cause noteworthy side effects???

Winlevi met its endpoints in the phase 3 study 6 months ago. Anyone who understands how clinical trials work care to explain the likelihood of a successful phase 3 trial going into market? The next step is apparently an NDA application. How often do these application get rejected?

cortexolone is supposed to be the metabolised cb , which is not antiandrogenic

 

[PeggyPeterson]

cortexolone is supposed to be the metabolised cb , which is not antiandrogenic

But does this metabolized cb have any oside effects? (Regardless of whether it is non-antiandrogenic)

I’m interested to know this because I was wondering if higher dosages is possible. @hilbert uses 2%. The latest study showed the best results at 7.5% twice daily. If side effects are insignificant, than wont hurt to go higher.

 

[Makaveli1988]

We need this how can we get it?

 

[Renegade000]

After seeing what happened to @Georgie , I don’t think I’d be interested in GB. this forum is best used for sharing info.

What happened?

 

[PeggyPeterson]

First she got accused of being a scammer after the delivery process took long, then one user got the product (WAY) but also got a refund.

The whole thing seemed unnecessarily burdensome (I wasn’t a part of it)..

Anyway, if you’re serious enough about hair loss that you’re willing to buy from a dodgy Chinese lab.. may as well pay a little extra and get it individually. Heck! Go on a vacation to China for a holiday if that’s what it takes to get it through customs!

 

[veneno]

if the lab can send it already mixed solution it will make it through customs, raw powder always seems susceptible

 

[Btg]

But does this metabolized cb have any oside effects? (Regardless of whether it is non-antiandrogenic)

I’m interested to know this because I was wondering if higher dosages is possible. @hilbert uses 2%. The latest study showed the best results at 7.5% twice daily. If side effects are insignificant, than wont hurt to go higher.

They say it is a natural body substance , anyway if cb goes systemic i guess it will have quite obvious sides , a paper from 2005 concluded that it is as potent as cypro

 

[PeggyPeterson]

The results look good for phase 1 (Attached here). They used a technique called hydroelectrophoresis to open up the pores.. I’ve never really heard of that process until I read it from Cassiopea.

Looks pretty impressive, just a bit curious about the active comparators they use. I’ve never heard of topical Cyproterone being recommended topically by clinicians..

 

[ScaredOfBalding]

Last I remember, Clascoterone turns into a corticosteroid as it hits the blood stream.

Also, there does not seem to be much difference in 1% and 5% Breezula, after they used hydro-electrophoresis to open up the pores. Then, I guess with some light dermarolling, we can use Winlevi efficiently.

Also, when Win and Fevi hits the market, we could still use topical finasteride in very weak concentrations (which does not go systematic, but has low efficiency).

Also the Breezula study is being done on 404 patients and only sides for 6 months were temporary local skin irritation, in few people.

finasteride + Brz + Seti is going to be a good f*****g stack for dealing with DHT.

Will Breezula not inhibit most DHT on the scalp? Have not read the clinical trials yet.

 

[mooreu]

We need this how can we get it?

The Kane Shop or Wuhan.

 

[PeggyPeterson]

finasteride + Brz + Seti is going to be a good f*****g stack for dealing with DHT.

What’s the story with Setipiprant? I have not seen it on Allergans plc’s pipeline, did they remove it? Or was it just not there in the first place? I wonder how their Phase 2 trial went, hope it was positive news, seems to work for @westonci

They do look like a nice side-free stack. I’ve also read somewhere that Clascoterone (Brz) also has a slight effect of reducing Prostaglandin D2.

 

[disfiguredyoungman]

I am trying this, will keep you updated.

 

[SamFT]

What’s the story with Setipiprant? I have not seen it on Allergans plc’s pipeline, did they remove it? Or was it just not there in the first place? I wonder how their Phase 2 trial went, hope it was positive news, seems to work for @westonci

They do look like a nice side-free stack. I’ve also read somewhere that Clascoterone (Brz) also has a slight effect of reducing Prostaglandin D2.

Allergens updated pipeline only has the drugs coming out in the next two years now. They took a bunch of them off I’m guessing because of that.

 

[Renegade000]

The Kane Shop or Wuhan.

Which is the more reliable source?
Any links to these?

Has anyone here had results from it?

 

[disfiguredyoungman]

Any ideas what I should use as vehicle? Hilbert uses a custom compound from a pharmacy, I don’t have this luxury.

 

[ScaredOfBalding]

Do u guys think that finasteride + breezula + minoxidil + nizoral will be a maintaining treatment for 20/30+ years?

 

[PeggyPeterson]

that sounds like a good combo as all four treatments work in different ways, however, you’d probably get sides from finasteride.

 

[ScaredOfBalding]

that sounds like a good combo as all four treatments work in different ways, however, you’d probably get sides from finasteride.

U think there is a higher chance of getting finasteride sides when u add breezula? Or u just think the finasteride side effect rate is higher than these observed in clinical trials?