Update: Follica's Presentation At The 2017 Aad Meeting

[coolio]

Why is it that ppl think they'll have a new product 2020? There is NO guarantee that the japanese will have a treatment ready by that time or even succed with their research. If Tsuj is ready by 2020 it could still be very long before any of us will be able to buy it.

This.


If Follica was posting the same results up to now, but doing it after a decade of steady press coverage & using their own new drug, the baldness community would be thrilled.


It creates some new terminal hairs and thickens existing areas.
The hairs will look normal. No funny direction, no lack of color, etc.
It's getting very near the market now.
It's almost surely safe.
It's probably compoundable if you give it a period of years to accumulate.
It probably won't even cost much.
It's less invasive than a transplant or many other of the potent multiplication ideas.

We should be f*cking happy about this.

 

[br1]

"probably", "maybe", "should".


Yeah.. super happy and excited about it..

 

[That Guy]

"probably", "maybe", "should".


Yeah.. super happy and excited about it..

All of the "probablys" that he listed are really just bonuses ontop of something that would already be good.

 

[Grasshüpfer]

Guys wtf did you do when you saw your hair fall off like f*****g flakes right in front of your eyes? I can't take this. I have a lot of hair on my head but I don't think it i going to last more than 6 months before everyone knows I am balding. f*** Brotzu, I thought that would prevent my balding and i would n't have to worry. f*** the direction in which my hairloss is going.

finasteride? Ru58441?

If I get a lung infection in winter I'm going to die, unless I take antibiotics.

 

[SamFT]

finasteride? Ru58441?

If I get a lung infection in winter I'm going to die, unless I take antibiotics.

Yeah well those antibiotics in winter aren't going to make you have erectile dysfunction either

 

[That Guy]

Yeah well those antibiotics in winter aren't going to make you have erectile dysfunction either

and finasteride probably won't either.

 

[Follisket]

Can we just stop comparing side effects like limp rubbery dicks and suicidal tendencies to f*****g headaches?

This is a hair loss forum, I'm pretty sure the people who come here are aware finasteride exists and have either explored that option already or rejected it - not without grounds.

It's true, there's little else to try but we don't have to be dicks about it (especially given it's the new research, studies and technologies section). The lack of alternatives doesn't make it an obvious solution. I mean, would we be condescendingly telling people to just cut their balls off if it wasn't for finasteride? (Not that there's much difference, necessarily)

 

[baldingAF]

http://puretechhealth.com/programs.php#follica

This is pure techs page about follica and RAIN and the first sentace says it does t just improve existing hair but also creates new ones. So even those at any level of thinning can go in.

They're still trying to get a trial in before release right? Or is it just them looking to get their medical device approved by FDA then train dermatologists?

 

[That Guy]

http://puretechhealth.com/programs.php#follica

This is pure techs page about follica and RAIN and the first sentace says it does t just improve existing hair but also creates new ones. So even those at any level of thinning can go in.

They're still trying to get a trial in before release right? Or is it just them looking to get their medical device approved by FDA then train dermatologists?

That's exactly what is says on Follica's site.

Anyway, the trial they hope to begin soon is the "pivotal" trial. It's the big kahuna of trials for safety and efficacy. Pass it with flying colours and you can get yourself FDA approved.

 

[br1]

That's exactly what is says on Follica's site.

Anyway, the trial they hope to begin soon is the "pivotal" trial. It's the big kahuna of trials for safety and efficacy. Pass it with flying colours and you can get yourself FDA approved.

So, how many decades away from the market?

 

[Pavi]

Please stop presenting supposition as fact.

Yeah! What is this, a Donald Trump rally?

 

[iamgotham]

Any news about this guys?

 

[Royaume]

Very interesting news from HLC2020 about Follica's treatment

Copied from HLC2020 (Steves Comment)

"Hey Admin,

I’ve stumbled across something amazing. I was doing a bit of digging around Follica’s potential treatment (I went through a load of patents). It boils down to this – Laser skin perturbation followed by an aplication of Lithium Gluconate (8% w/v). The at home topical compound will include a BMP-inhibitor (they namecheck Dorsomorphin), a WNT modulator, and an EGFR inhibitor.

I didn’t really think that much about the EGFR inhibitor at first, but as I was reading something became quite apparent. The names! The drugs listed in the patents include:

Canertinib
Vandetanib
Pelitinib
Various other with XX-yyy code names

Notice the “nib” ending to these names? All of these drugs are Tyrosine Kinase inhibitors! What makes this interesting is that a Janus Kinase is just a type of Tyrosine Kinase!

This is exciting for all sorts of reasons –

1) Gives strong evidence that Dr Christiano is correct about kinase inhibitors
2) Shows that Follica is much more than the “dermarolling plus minoxidil” nonsense you read on some of the forums
3) We could have access to kinase inhibitors way before Aclaris are done
4) Follica could now potentially be the company to prove your prediction correct!"

Furthermore someone found out that Dr. Neal Walker (President and CEO of Aclaris) is also on the board of directors in follica.

Huge news if you think about the potential power of JAK inhibitors in
connection with follicas laser skin disruption.

 

[baldingAF]

That's a solid find on his part. In most aspects from the believed cyclosporine a method of helping hair loss (nfatc1) to BMP inhibitors you always find a mention of STAT/JAK pathway being involved but I was always put off by its relation to the androgen aspect. For sure gonna look more into these listed compounds

 

[Swoop]

HLC is a terrible site if you want to get educated and get as close to the "truth" as possible. It's a blue pilled site. You step into unicorn land if you read there. Great site if you want to feed on your hope though.

If you want to swallow the red pill I advise you too engage in other sources of information and use your own brain and discuss it with people who do the same.

Furthermore someone found out that Dr. Neal Walker (President and CEO of Aclaris) is also on the board of directors in follica.

Is that a good thing, that he is involved in both? It surely gives food for thought for the people who like to fly to the sky and dream away.

Meanwhile I literally dominated Neal Walker. He relied on observations of a rodent model while I relied on observations of actual humans. Few weeks later studies come out which prove that I was right and Neal Walked was wrong.

A nobody like me dominating a CEO like that. It doesn't even move me, but it is somewhat comical.

 

[butler]

Before writing this did you at least read the comment or look at the link to the patent thy was posted?

 

[Infinti24]

Swoop I'm pretty sure you said JAK inhibitors would never work for Androgenetic Alopecia. Hasn't been proven yet but signs are starting to point in the right direction at least. Not sure why you're so quick to shoot it down.

 

[pegasus2]

The patent doesn't say what they will use. Regardless, it's basically the same thing.

The removal of dermis tissue at the target area may be accomplished by any suitable technique, including a fractional ablative laser, a punch biopsy needle, a microneedle, a micro-coring needle, a blade, a drilling bit, a fluid (e.g., water or gas) jet, or another suitable modality.

http://patents.justia.com/patent/20130204238

 

[baldingAF]

I think it's safe to say that follica won't just be dermastamp/laser with minix. A skim of a few of their patents says tentative use of things from anti inflammation, antioxidants, wnt regulators, bmp inhibitors, tyrosine inhibitors, autoimmune drugs and so on. It makes no sense for them to cover all that much just for patent rights then turn around and blast rogaine in holes on your head. Starting to see some real precision and finesse in follica's approach

 

[Swoop]

Before writing this did you at least read the comment or look at the link to the patent thy was posted?

I did. But it took me 5 seconds to conclude that that comment is full of grandiose unrealistic dreams.

Swoop I'm pretty sure you said JAK inhibitors would never work for Androgenetic Alopecia. Hasn't been proven yet but signs are starting to point in the right direction at least. Not sure why you're so quick to shoot it down.

I still stand by that. They will indeed do next to nothing.

I agree regarding that site - it's totally biased, and suffers from a major conflict of interest since he pushes protocols with one hand while accepting advertising dollars for those services with the other.

That being said, I don't get your Follica hate. It's clear you have some sort of personal vendetta against it, and often misrepresent what they are doing (for example, you keep claiming that all they will offer is needling and minoxidil, when the patent clearly states over and over that it will be laser ablation).

I'm not hating Follica. What makes you think that?

Also I said they will be offering microneedling or dermabrasion in combination with one compound initially, and yes this will be minoxidil. We don't have confirmation of this but I'm highly sure that I'll be right. Everything points to it. Simple as that. Recent news of two days ago : http://www.investegate.co.uk/puretech-health-plc--prtc-/rns/final-results/201704060700157354B/.

Follica is progressing the development of its proprietary, in-office skin disruption therapy that induces follicular neogenesis and enhances the new follicles with an active drug compound. Follica is initiating a pilot optimisation study mid-year, with a pivotal trial expected to begin in the second half of 2017.

Now what compound would that be? Hmmm...Yes, minoxidil baby.

Now in the long term future that's another story. Yes, Follica might research novel compounds that might work even better or in combination with minoxidil. But that process will be a long long long process, because we all know how long drug trials take. We are speaking about many years here. They are going for 510K approval only now for their medical device.

Your notion of them using a laser is just simply unrealistic. A patent often describes a wide range to protect their IP. You can't just derive factual information from a patent. But have you actually looked at their patent? Dermabrasion outperformed the laser when used solo as TCP.

As shown in Table 7 below, all four of the modes of integumental perturbation produced activated hair follicles. Dermabrasion (using the Aseptico Econo-Dermabrader from Tiemann and Company) resulted in the highest number of activated follicles, and among the laser treatment modalities, treatment with fractional laser resulted in the highest number of activated follicles.

Furthermore how do you even see this from a practical, let alone financial standpoint? Have you ever educated yourself on lasers? Here is a quick link: http://www.skinacea.com/facials/lasers/types.html#.WOeW3kXyhaQ

There are only a couple of lasers approved by the FDA. These ain't exactly pocket handheld lasers and are expensive. Remember that Follica is going to produce the medical device. Do you seriously think Follica has the cash flow to start mass producing lasers like this:

?

And I don't hate on Follica. If it's microdermabrasion or microneedling in combination with minoxidil it's still better than minoxidil alone. And I see they want to reach a wide public with this treatment, because a lot of people don't seek out for treatments at the moment. This picture says all:

98% of elligible Androgenetic Alopecia patient do not receive treatment in the US.

So let them work with physicians, hair transplant doctors and clinics to reach a wider public and use that holy old minoxidil with their TCP technique to pump money into this market.

I won't hate them for doing that. The more money pumped in this market the better.

But I'll cheer if they get swooped completely out of this market by superior treatments. And that's where my hope lies. Actual companies that have the capability to launch something truly great in the near future, like Dr. Tsuji.

Follica simply isn't one of them, at least in the near future.