Toccata
Banned
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I've been asleep since 2008—How's Follica?
Just 5 more years... LOL
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Just 5 more years... LOL
This could be Follica's marketing slogan "We're just scratching the surface" XD
[/QUOTE
Anyone else's eye go STRAIGHT to the dude in the pic with the thick, lusciuos hair!?!??! Story of my life...It has become an instant reactionary thing I do now, no mattter where I am, what I am doing, what I am watching. Really sad stuff...
I wish a cure was already here.
I have been waiting for either Follica or Histogen or Replicel/ Sheishdo since 2013. It was in 2012 when PGD2 discovery was made and a cure was promised in 2 years (yeah, not 5 but 2). I have been bald for 7 years now and I have forgotten how it is to have my crown completely covered - something which i used to take for granted before that. I am just so depressed.
I am thankful to researchers for their work but can you please hurry...
Hey @karankaran I've been tracking Follica, since this infamous video:
That was almost 10 years ago. It seemed really promising but now I just think that this is some sort of Minoxidil + Dermarolling treatment and it will probably hit market only in 2019/2020.
Histogen is the same thing, no major developments, some suspicious pictures and a promised release in Mexico in 2018 (probably more likely in 2020... or never).
One thing is certain none of them will be the so awaited cure. Personally if one of this 2 could stop the hairloss process I would be more than happy. I would just make an hair transplant and have a normal life without been completely depressed and obsessed with this sh*t.
Sorry for the rant guys, but today I had a really shitty day.
But the results would be so amazing that could bring people that are a NW3 to a NW2 or even NW1?
I honestly don't believe in this... 10 years to develop some dermarolling bogus for you to apply with Minoxidil doesn't give any hopes.
10 years only to have dermarolling + minoxidil in the next 5 years. What a dissapointment...
In a rare example akin to organogenesis in adult mammals, large wounds in mice lead to de novo morphogenesis of hair follicles. It is still not fully clear what controls this process, known as Wound Induced Hair Neogenesis (WIHN). In other tissues, prostaglandin E2 (PGE2) is an important effector of regeneration and has been shown to stimulate the Wnt/beta-catenin pathway, which in turn is known to control WIHN. Previously, our group has demonstrated that noncoding dsRNA released during wounding is both necessary and sufficient to stimulate WIHN through TLR3. Here, we hypothesize that dsRNA similarly induces the beta-catenin pathway through PGE2. We find that WIHN levels correlate closely to Wnt7b production in vivo, and that dsRNA potently induces Wnt7b in a manner that requires prostaglandin-endoperoxide synthase 2 (Ptgs2). The Ptgs2 inhibitor celecoxib reduces dsRNA-induced WIHN and Wnt7b, and exogenous PGE2 can rescue WIHN and Wnt7b. Although other wnts and pathways likely contribute, these results highlight noncoding dsRNA as an upstream coordinator of prostaglandin and Wnt levels in regeneration.
Long time lurker...*first post*! Hi to ALL of you
A question for you @Swoop ;
Since you are (roughly) sure about the actual process of, or the procedure as a whole that Follica will be offering - would you add that to your regimen today?
If yes - how would you go about it? 1,5 mm derm? Dermabrasion?!
If not - why? The theory or mechanism of action is supposedly verified in the Indian study.
Hope you can take the time to give your honest opinion.
Cheers
- Topical anesthesia with 4% lidocaine cream (Dermomax® Laboratorio Aché, São Paulo, Brazil) was carried out 30 minutes before the procedure. After this period, the cream was removed with saline, and the antisepsis of the entire area to be treated subsequently performed with alcoholic chlorhexidine. Once the area had been completely dried, a fenestrated sterile drape was put in place delimiting the area to be treated. - Removal of the tip from the sterilization envelope, and coupling of its distal end to the Cheyenne® apparatus, and its proximal end to the cartridge with rowed needles (model 17-bp-Magnum) (Figure 1). A small sterile container was opened for the insertion of the medication (0.5% minoxidil, injectable solution, Healthtech dispensing pharmacy, Anvisa 9003878, Rua Teresina 208/210, Vila Bertioga, São Paulo – SP, Brazil). - The apparatus’ speed was set at 90. The medication was aspirated from the sterile container into the cartridge just as it comes in contact with the needles by their rapid back and forth movement, when the device was turned on. The microneedling and drug delivery process was effected through the perpendicular puncturing of the epidermis, with manually adjusted depth at roughly 1.5mm. Renewed aspirations of medication are necessary when the amount in the cartridge is used up. The procedure is completed when a pinpoint bleeding is produced throughout the treated area (Figure 2). The cleansing after the procedure was performed with a gauze moistened in saline. Post-procedural care includes gentle washing with a neutral shampoo 6 hours after the procedure and the use of simple analgesics in case of local pain. Post-procedural photographs were taken 1 month after the 4th session (Figures 3 and 4).
Long time lurker first time poster.
Has anyone ever read that article about Daphne Zohar, CEO of Puretech health in Fierce Biotech? It seems like solid evidence to me that Follica is using something else than minoxidil? Perhaps things have changed though since this article was published in 2008. Anyway here's the relevant quote from Daphne Zohar regarding the compounds used by Follica:
"What's nice about it," she adds, "is that even though this is based on breakthrough science, we are using existing compounds previously approved for systemic chronic use and reformulating them for topical acute use. We know these compounds are safe in people."
You can't really do dermabrasion yourself. I would just follow something like the R. Dhurat study I guess?
I actually keep minoxidil as a backup for myself. If I need to add anything again to strengthen my hair in the future it will be minoxidil with dermarolling. I would use something of a protocol like described in the following paper: http://www.surgicalcosmetic.org.br/...ica-de-microinfusao-de-medicamentos-pela-pele
I actually thought that article was recently. If that would be true it would be quite a strong counter argument against them using minoxidil. Considering that it is from 2008 however she is refering here to lithium.
Follica actually did trial lithium at a 8% concentration but it did not enhance their TCP technique. So yeah that failed in the past.
@Swoop
Thank you for the reply.
Didn't know about that paper.
It sure seems like a lot of hassle to do it (infection-risk-free) the right way.
Anyway; hope that Follica at least manages to streamline this, to the degree that the average consumer finds it convenient.
It does however, as you point out, give you another angle of fighting Androgenetic Alopecia and does that with pretty clear
instructions as how to do it (with the hassle downside as mentioned).
I have understood that you maintain with finasteride and RU periodically. When on RU - is there
any reason why you don't already dissolve it in minoxidil?
Cheers