- Reaction score
Wouldn't RU be better? I know that the safety concerns might be holding us back but hopefully we can get more information via contacting the people whom was involved in the human studies.Exactly. Finasteride is a smaller molecule that crosses both non-hair shaft skin as well as entering hair shafts therefore it will always get through the skin easily. The lactoferrin was able to enter only via the hair shaft where it was able to stay more localized which is what we would want with dutasteride. Lactoferrin and other large molecules do not readily cross non-hair shaft skin easily otherwise there would be a lot more drugs that could be delivered transdermally that currently aren't.
There are definitely issues with the 500 limit number due to the many factors that affect absorption through the skin. For example, most early studies that defined this limit had been done on areas of the skin other than the scalp. The scalp has a huge number of large, terminal hair shafts versus other less hairy areas of the body. These non-scalp types of studies aren't very applicable to us as the absorption dynamics would be totally different in the two scenarios with a greater number of larger molecules getting into the hair shaft on the scalp.
I used oral finasteride in the past and eventually had sides after many years of use. When everyone started talking about topical finasteride again a few years ago (with many prominent doctors jumping on the bandwagon) I was surprised because topical finasteride had been discussed over a decade ago with most people coming to the same conclusion: the finasteride molecule is just too small to not pass straight through the skin and into systemic circulation. From many people's reports, this has clearly been the case.
I guess for those of us too afraid to try topical dutasteride or any other experimental treatments just yet, all we can really do is look forward to clascoterone being released within the next few months. It doesn't seem great but the studies seem to indicate that it is safe and safety is currently my main priority.