You don't want it to penetrate , that is the entire point. It should be degraded or prevented from reaching the hypodermis and vascularizing but reach the dermis.
I did a scalp biopsy and my DHT was almost non existent on my scalp while I had low-normal levels in my blood.
This is ideal.
I guess I should have been clearer. We don’t want it to go systematic. However, we want it to get to the follicle.