The Cb (breezula [clascoterone]) Community Thread

tomJ

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The target is July 2020 for the FDA approval of the CB for acne so we can have pharmacies compound a higher % until Breezula
How difficult do you think it will be for us to purchase the acne version online if we want to try that first?
 

topicalthunder

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The target is July 2020 for the FDA approval of the CB for acne so we can have pharmacies compound a higher % until Breezula
I wonder when it will get approval in Europe. That’s a separate process unfortunately which I’m not sure has been applied for? :(
 

carvo08

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The target is July 2020 for the FDA approval of the CB for acne so we can have pharmacies compound a higher % until Breezula
Are you sure about that?
Do you know any drug that has an active patent and is being compounded in a pharmacy?
I don't know if it's allowed...
 

recedingdude123

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I wonder when it will get approval in Europe. That’s a separate process unfortunately which I’m not sure has been applied for? :(

this is just a guess but given that they are an italian company, i would assume they are pursuing both simultaneously, if not aiming for a european release first
 

Jim lahey

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I wonder how well the 1% works on hairloss, im already on finasteride and minoxidil so im just looking for a little boost on the hairline.

Im also planning on getting it from either lyphar or kane if anybody has ordered and or tested and can lmk if either can be trusted. Probably leaning towards lyphar rn.
 

hemingway_the_mercenary

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guys the problem with topical AAs is absorption. less than 2% of the applied CB will reach the follicle so its very challenging to get a sufficient dose to outcompete androgens as these drugs have 50-100x weaker binding affinty for the AR
 

bluecyclone

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How hard would it be to transition from RU to CB?

Would this increase risk of up regulation? Shedding? Finasteride isn’t working and I’m just not sure I can pull the topical Dutasteride trigger while still planning a family. Granted RU my be a far bigger ‘risk’ but the loss/decline of fertility on Finasteride and Dutasteride is well documented.
 

el_duterino

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loss of fertility on finasteride ? never heard that one.
CB is topical only so you need much more because its easier to bring the drug to the follicles via blood stream
 

Dimitri001

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Pardon the newbie question, but I've heard CB is supposed to have the AA effect only locally in the follicles and not systemically, is that right? Is there any research confirming this?

How hard would it be to transition from RU to CB?

Would this increase risk of up regulation? Shedding? Finasteride isn’t working and I’m just not sure I can pull the topical Dutasteride trigger while still planning a family. Granted RU my be a far bigger ‘risk’ but the loss/decline of fertility on Finasteride and Dutasteride is well documented.

Beg your pardon? Is this true? Can you link to research?
 

HairSuit

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How hard would it be to transition from RU to CB?

Would this increase risk of up regulation? Shedding? Finasteride isn’t working and I’m just not sure I can pull the topical Dutasteride trigger while still planning a family. Granted RU my be a far bigger ‘risk’ but the loss/decline of fertility on Finasteride and Dutasteride is well documented.

I am by no means a medical test case, but I have three, healthy, little mouths to feed. I had zero issues with fertility. That said, after years of use with finasteride, I also have PFS badly. Have suffered for the last two years. But, was on finasteride, minoxidil, and RU while all three were born. Zero issues.
 
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bluecyclone

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That’s great to know. This was from two different urologists. They didn’t say it would kill fertility but said it can reduce speed volume and quality. The conversation came as I was experiencing ball ache and very water semen after trying Propecia for the second time.

My guess is that for some it is no issue the same way some get sides and some don’t. I got sides and it hasn’t helped slow my hairloss so I’m looking for other options.
 

supermusic

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Maybe mesotherapy with CB would be more effective, although I don't know if it would involve risks of side effects.

Has anyone tried the Chinese cb for acne? It would be a good way to know if it really is effective.
 

James Oliver

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I got quite a bad 'crash' of symptoms from just topical saw palmetto. 3x 1ml dosages, gave me head aches so i stopped... 3 days later dick felt numb and eye sight went weird for a bit. 3 days later im fine. Does CB0301 have the potential to really be the no sexual side inducing drug? Minoxidil has even led to some sexual problems for people, lots of reports on propeciahelp forum.
 

irao33

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Has anyone had any issues ordering CB lately from Wuhan/Alibaba or Kane? Are there any risks given the virus?
 
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