Samumed Sm04554 Results Normalized To Baseline

-G-

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Enough to know if it definitely works, i'd say like 40. And about 60/70 in the discord server.
Cann you guys start a new thread maybe with actual pictures, before/after?

Words can only do so much.
 

pegasus2

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Cann you guys start a new thread maybe with actual pictures, before/after?

Words can only do so much.
No we don't intend to publicize it right now. However, we would be happy to share our results with the lab that has ordered the drug if they want to reach out to us.
 

Pigeon

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I don't understand the critical attitude. Don't get me wrong, I am completely on your side and understand your frustration. It is no different for me when you consider how the last "miracle cures" ended soundlessly in oblivion and we are always 4 years away from the cure ... and have been for over 20 years! Nevertheless, there cannot be other reasons why the results for the 3rd trial are withheld? Overall, they seem to be preparing for a market launch, which could explain that. I dont know. I was also confused that they assumed they would publish other products from their pipeline first. I have no idea why this is the case. Perhaps they are hoping for more money or support?
To be honest, a product that has similar effects as minoxidil or finasteride, without the side effects (was affected by both) would be sufficient for me.
Nevertheless: Can't we first make a judgment after the results? Or does someone have more information than me? : D
I'm more sceptical because of the latest interview, especially this part:

"The company currently has a candidate, cirtuvivint, in Phase I for patients with advanced solid tumors. And its androgenetic alopecia candidate, dalosirvat, is scheduled for a Phase III readout in the next four to six weeks, Horsley said. However, the company expects the OA program to be the first to market."

Maybe they're talking about the american market and because the phase III trial is in Turkey they'll have to do another trial in America to bring it to market there (although I doubt that) and of course the other things like jumping on the mRNA hype train due to covid, CEO stepping down, IPO,...

Too many red flags to ignore now imo. But you know, we could be wrong and Samumed/biosplice could be completely legit. Anyway it won't be long untill we know the results, we'll see what the company will do then...
 

franzliszt

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I don't see this as a stand alone treatment, when combined with other meds the result will likely be better than the phase 3 results. I'm not looking for a miracle cure, just a minoxidil alternative, that hopefully won't make me feel 10 years older.
 

Pigeon

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I don't see this as a stand alone treatment, when combined with other meds the result will likely be better than the phase 3 results. I'm not looking for a miracle cure, just a minoxidil alternative, that hopefully won't make me feel 10 years older.
Sure, if this will only give maintenance and maybe a little regrowth without any (serious) side effects, I would consider this a huge success.
 

Anatman

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I don't see this as a stand alone treatment, when combined with other meds the result will likely be better than the phase 3 results. I'm not looking for a miracle cure, just a minoxidil alternative, that hopefully won't make me feel 10 years older.
this is what i wish for. just an alternative to minoxidil and finasteride, which hold the hair that I still have and maybe make it even thicker. that would be enough for me.
however, phase 2 looked promising and still beat minoxidil and finasteride, at least on paper. So is it not enough on its own together with microneedling? we will only know after the results of phase 3.
it is still painful to see that it always seems to fail in phase 3. The previous speakers are right. there are clear inconsistencies that should make us all skeptical.

@Piegon
I totally agree with you, but the question still remains how expensive it will be and whether the results will allow a release.
after all, minoxidil and finasteride are not expensive (10 euros for 1 month of minoxidil in Eu and 30 for finasteride per month) and the market is unpredictable.
 

trialAcc

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Interestingly enough, BioSplice just posted very positive results for their phase 2b Lorecivivint trial that ended 9 days prior to the Androgenetic Alopecia trial as well as their phase 1 solid tumor trial that ended before both of them.

The argument that they would have published positive results already seems to be false judging by this release. Perhaps they could still have a surprise for SM04554? They did rename the compound to an actual drug name on their website.
 

5minutesbeforemiracle

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Interestingly enough, BioSplice just posted very positive results for their phase 2b Lorecivivint trial that ended 9 days prior to the Androgenetic Alopecia trial as well as their phase 1 solid tumor trial that ended before both of them.

The argument that they would have published positive results already seems to be false judging by this release. Perhaps they could still have a surprise for SM04554? They did rename the compound to an actual drug name on their website.
Bruh, you tryna give us hope again? :')
 

Pigeon

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Biosplice Publishes Successful Clinical Trial in Knee Osteoarthritis


SAN DIEGO, April 26, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. (“Biosplice”), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today the publication of its successful Phase 2b knee osteoarthritis clinical trial data in Osteoarthritis and Cartilage. In this 24-week clinical trial, Biosplice’s groundbreaking knee OA drug candidate, lorecivivint, met primary endpoints of Pain NRS (daily pain measurement) at both 12 and 24-week timepoints. As in previous trials, lorecivivint appeared safe and well tolerated.
 
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Anatman

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Interestingly enough, BioSplice just posted very positive results for their phase 2b Lorecivivint trial that ended 9 days prior to the Androgenetic Alopecia trial as well as their phase 1 solid tumor trial that ended before both of them.

The argument that they would have published positive results already seems to be false judging by this release. Perhaps they could still have a surprise for SM04554? They did rename the compound to an actual drug name on their website.
Thanks. Now i have Hope again. :/
 

byebyehair

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Interestingly enough, BioSplice just posted very positive results for their phase 2b Lorecivivint trial that ended 9 days prior to the Androgenetic Alopecia trial as well as their phase 1 solid tumor trial that ended before both of them.

The argument that they would have published positive results already seems to be false judging by this release. Perhaps they could still have a surprise for SM04554? They did rename the compound to an actual drug name on their website.
The renaming of the drug happened two some time before the renaming of the company. (according to a comment on hlc2020)
 

trialAcc

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Bruh, you tryna give us hope again? :')
I just think that it is worth noting that they proceeded to change their name and actually had positive news to report despite a re-brand and CEO change. Most people here (myself included) completely wrote them off as soon as this happened.

The Androgenetic Alopecia drug was still a footnote in their presser, so I'm assuming it will still have weak results but you really never know.
 
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