so recently I think there has been quite some research on topical drug delivery and I read a paper from 2022 that goes over all of them recently. not sure I can find it. the problem with this is that while any pharmacist can probably make them its not like you can easily test what you get is actually the proper thing. a mistake in the process can f*** up the entire base in the vehicle and either make it impossible to penetrate or it just penetrates like alcohol and gives side effects. I think the best way to convince them is to make them a price offering. however these would all be individually made and thus quite expensive I imagine. a liposomal from the pharmacy already costs quite a lot and they usually make it for many people and have some kind of process set up. in case of pyrilutamide, the problem with compounding pharmacies is that they cant make it because the active drug is illegal for use.
Finasteride (finasteride), a 5-α reductase enzyme inhibitor is mainly used orally for the treatment of androgenic alopecia and benign prostate hyperplasia. The present study was undertaken for systematic optimization and assessment of the designed nanostructured ...
www.ncbi.nlm.nih.gov
Finasteride is considered the drug of choice for androgenic alopecia and benign prostate hyperplasia. The aim of the study was to formulate nanodrug carriers of finasteride with enhanced retentive properties in the skin. The finasteride was formulated as solid lipid nanoparticles that were...
pubmed.ncbi.nlm.nih.gov
In the present study, iron oxide nanoparticles, in the form of maghemite core coated with lauric acid (ION), were synthesized and loaded with finaster…
www.sciencedirect.com
"Nonetheless, dutasteride-ION application on skin also did not lead to drug penetration in the receptor compartment when Franz diffusion cells were used, and more meaningful, despite increasing dutasteride distribution in the stratum corneum and within the hair follicles, did not further increase dutasteride penetration in the remaining skin compared to the control solution"
"experiments did not detect finasteride in the receptor solution when the finasteride-ION permeation experiment was performed in Franz diffusion cells."
so there is a lot of info about how to make these things when you have the tools. I dont understand why no company is jumping in these studies, probably because there is not much money to be made. some are quite promising and they use Franz diffusion cells with human skin to check if the solution permeates the dermis and how much retention there is.
someone would need to dig through the studies and find out if it could work for pyrilutamide. (based on molecular size and charge etc, I dont know much about that). or ask a chemist. there was a guy on tressless recently who seemed in this area and had an idea for a vehicle and was searching for people to test it. but these things from the internet have never worked out..
then contact the lab if they could even do that. I assume if they can make the molecule they could make the solution as well if there is enough demand? again however, you'd need some kind of way to ensure that they are doing it right and that is probably not so trivial.
I personally think that it would be much more feasible to have significant progress in hair loss research by making things we already have work well instead of researching new chemicals. because ultimately the androgen receptor is the primary target and of course you can target anything downstream however there are so many pathways involved that it is extremely hard to achieve something meaningful and this has been shown over and over again through the failure of companies like samumed, follicum, histogen etc. all who tried to address pathways downstream that are ultimately altered by androgen receptor action.
then the question becomes though why Kintor with the funding they have would not make such a solution themselves. and maybe they have if they are so certain that there is no systemic action, maybe everyone is just using it without the proper vehicle. however id be surprised if that is so and if they aren't just using stupid ethanol pg. it will be really interesting once they have a phase 3 application in the US because then they will have to publish what vehicle they are using and how they prepare the whole thing. I hope its not ethanol. I think that'd be a lost opportunity but I can almost bet they are doing that because its cheap and seems to work well enough. however if you go the way of expensive trials, why not go the whole way... ethanol is such a dumb way to deliver a f*****g anti androgen to the skin only. they make super advanced PROTACs and then use alcohol to deliver them would be REALLY dumb.
in 2022 we have so many alternative options, from nano carriers to liposomal solutions in every variation, studies show it is possible to have 5* the drug in the skin with high retention and minimal diffusion past the dermis into the system so why not make use of that research. thats what I dont understand.
I think hasson and xylon went in the right direction however for the wrong reasons. also they made theirs stupid high in concentration and did not publish anything from the case studies to the actual vehicle because they are in it for the money and not scientific progress.
imagine a vehicle as described in these studies that combines dutasteride and some anti androgen and it has maximum local retention and minimal systemic impact, that would be better than anything a new company can come up with. or maybe its not even possible in vivo. I wouldn't know why though because the Franz diffusion cell literally uses human skin samples to make realistic. olix are also testing their iRNA molecule with this method. I think the future lies in proper delivery but I dont see anyone in industry getting serious enough about it at this point
