Kintor has started Phase 3 trial in China for Pyrilutamide

Micky_007

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"On January 2, 2022, Kintor Pharmaceutical announced that the first male subject has received a dosing in their phase 3 pivotal trial of pyrilutamide. The phase 3 trial of pyrilutamide in male androgenetic alopecia will include:

Randomized, double-blinded, placebo controlled parameters

- 416 male trial subjects
- A duration of 24 weeks/6 months
- A primary endpoint of change in number of non-vellus target area hair count from baseline to week 24

Kintor remains ambitious in this press release, which has become their M.O., and states that they intend to complete this trial by the end of 2022. Dr. Youzhi Tong, CEO of Kintor Pharma, had this to say: “We look forward to completing the planned 416 subjects enrollment by June 2022, and the follow-up medical evaluation(6 months study + 1 month follow-up)within the year. With the goal of completing the phase III clinical trial this year, we are speeding up the process and expecting that KX-826 would benefit global patients as soon as possible.“

Credit: Follicle Thought

 

fashy

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First real alternative to finasteride possibly coming out next year, this is a huge milestone provided all goes well. Their phase II report will either make it or break it, we should know if we'll have the alternative we want and need this month (in case they don't delay the report again). Hard not to be optimistic though.
 

whatevr

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I will only get hyped after we know phase II results...

@whatevr what do you think? Will this go systemic too?

We went over this in that other thread a few days ago. At the doses they are planning to use, it wasn't detected in the serum. But, I'll reserve judgement until I hear real world reports from users.
 

Micky_007

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Well atleast I respect Kintor's honesty when it comes to finasteride: "severe sexual adverse effects"


They also state their product doesn't effect androgen levels... I want to believe...

Yeah love the fact that they state "severe sexual side effects" with Finasteride usage, because it shows confidence and also, if Pyrilutamide side effects were anywhere near as bad a Finasterides, this statement could be used against Pyrilutamide.

Hoping for the best, yet staying cautious.
 

fashy

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Well atleast I respect Kintor's honesty when it comes to finasteride: "severe sexual adverse effects"


They also state their product doesn't effect androgen levels... I want to believe...

I do believe it doesn't affect Androgen levels, their own data from both phases I shows it does not go systemic therefore it would make sense that it does not. The million dollar question is how effective it is though. A topical AR antagonist that does not go systemic sounds great but it can also rouse skepticism about how potent it really is if does not penetrate the blood barrier at all.

Hopefully it also has longetivity in its effects and they do not decline 6-12 months in like CB or minoxidil. These are the 2 cruical aspects as to whether this will work or not. Fingers crossed.
 

fashy

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No word on whether phase II results will become public though, that's annoying.
 

fashy

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Heard rumours about them making it public in some dermatology conference? Haven't seen any proof though.

Yes, I posted that in the other thread I believe because it was posted by a user in one of the discords who had contacted them. I saw the screenshot and it looked legit, but dermatology conference still doesn't tell us much.

Anyways, I emailed Kintor yesterday about this too so hopefully they respond.
 

byebyehair

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Well atleast I respect Kintor's honesty when it comes to finasteride: "severe sexual adverse effects"


They also state their product doesn't effect androgen levels... I want to believe...
Why the hell shouldn't they use every negative point of theyr competitors :D

I'm really excited for their report. Do we know if it will be an over the counter product or if u need suscription in china?
 

Micky_007

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Do we know what dosage they'll use in this trial?

Not that it matters for now seeing as we do not know for 100% certain if the chemical structure they are using in the trials is the exact same as the 2015 Patent for Example 12,which is the only one they claim direct comparison against RU.

They could have tweaked it a bit since then as 2015 was a long time ago, maybe as a way to throw a curve ball at those trying to replicate their findings before they release to market.

Similar theory I have about their Phase 2 results delay, my guess is that their holding their cards close to their chest because they know that once people find out how safe Pyrilutamide is potentially, people will try to obtain it ASAP via the Grey markets. So their probably going to release the remaining trial results close to the time of market release. That's just my guess, I could be wrong on it, but it makes sense from a business standpoint.

Also, since Pyrilutamide is said to be far stronger than RU, and we know that RU causes side effects for many people, I wonder if Microneedling with Pyrilutamide would be a big problem because it would cause far more systemic absorbtion of Pyrilutamide.
 
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thatslin

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Honestly, I know someone who was one of the participants of phase II trial and he was given placebo treatment as control. He said that many dudes from other test groups had real decent amount of hair regrowth after 6 months. Yes, regrowth. Pyrilutamide might work pretty well for many but the question is how long it will last and of course the sides. I remember CB0301 had awesome effect in the beginning and went sh*t after 12 months.
 

thatslin

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Did he mention anything about side effects from the guys using legit Pyril?
According to his words, no noticeable or severe side effects but who knows? He probably only asked one or two people out of the other hundreds of participants. And will there be any side effect in the long run? We don’t know. It seems like Kintor is pushing the pace and maybe that is called business cause money doesn’t wait.
 

fashy

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Honestly, I know someone who was one of the participants of phase II trial and he was given placebo treatment as control. He said that many dudes from other test groups had real decent amount of hair regrowth after 6 months. Yes, regrowth. Pyrilutamide might work pretty well for many but the question is how long it will last and of course the sides. I remember CB0301 had awesome effect in the beginning and went sh*t after 12 months.

Um, I seem to recall a post on here somewhere ,from a Chinese forum, of a guy who had allegedly participated in the phase II trials who wrote that he may have been given a placebo cuz he had no results, but some of the other participants were growing hair.

Either you're the same guy somehow or you're just verbatim repeating what the post had said.
 

thatslin

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Um, I seem to recall a post on here somewhere ,from a Chinese forum, of a guy who had allegedly participated in the phase II trials who wrote that he may have been given a placebo cuz he had no results, but some of the other participants were growing hair.

Either you're the same guy somehow or you're just verbatim repeating what the post had said.
Probably not the same person unless the guy I know posted on the forum you mentioned. Being in the placebo group and seeing positive results on some participants from other group, is not a rare thing. The coincidence is that they were both from the placebo group, and that’s it.
 

fashy

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Their covid 19 phase III trial failed though:


Kintor Pharmaceutical has reported interim assessment data where its nonsteroidal antiandrogen, proxalutamide, failed to meet statistical significance in Phase III clinical trial to treat Covid-19 in the outpatient setting. The data was collected from 348 subjects with mild-to-moderate disease.

This was already discussed and is irrelevant to pyrilutamide.
 

Adri23

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My question is, if this ends up working and get released to the market, could this be able to stop hair loss for people like me who is on dutasteride and oral minoxidil and still slowly losing ground or it wont be that powerful as dutasteride + oral min??? Could this be stacked with dutasteride and minoxidil for further efficacy?
 
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