Kintor has started Phase 3 trial in China for Pyrilutamide

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Jackshtbro

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hmmmmmmmm said:
Just want to add - there’s a lack of objectivity that cripples these groups as well.

There’s a lot of smart people involved, but they don’t apply sound reasoning to their own progress sometimes

E.g. I had a conversation with somebody named “Oscar” on one of the discords a few months ago, and believe he works in biotech.

He started topical dutasteride and E3 at virtually the same time, regrew some hair, and attributed part of that success to E3.

Then he cited a patent from 1950 or something.

In any other context I suspect he’d agree that using the most powerful approved Androgenetic Alopecia treatment is a big confounder to that experiment…
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You missed the part where he had been on oral finasteride for a year already at that point (before switching to a very low dose topical dutasteride), so it's not that clear cut
 
RoryGall29

RoryGall29

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Any specific date/time for the September conference? I hate that they just announce the month and not the specific day...
 
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corkmeister

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Seems like it's basically the same cycle with any drug now.

1. It's the best thing ever with no side effects
2. It works, but there are side effects
3. It doesn't work, and there are side effects
4. It actually accelerates hairloss and makes it worse, and there are side effects
 
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RagnarLothbrok

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corkmeister said:
Seems like it's basically the same cycle with any drug now.

1. It's the best thing ever with no side effects
2. It works, but there are side effects
3. It doesn't work, and there are side effects
4. It actually accelerates hairloss and makes it worse, and there are side effects
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5. Trial results come out: it is not flattering but beneficial enough to include in a hair loss stack.

(most likely scenario)
 
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Jackshtbro

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hmmmmmmmm said:
This makes it worse, not better as an experiment. I was actually downplaying how bad the reasoning he applied was

From memory, he changed all these parameters at once:
1. Stopped finasteride
2. Started topical dutasteride (very limited data on how well dutasteride works in this modality)
3. Use custom homemade topical vehicle instead of standard, made in large batches where the formulation wasn't consistent month to month
4. Included Estriol

I don't remember timeframe, but I think it was under 6 months (too short timeframe)

And his evaluation was looking in the mirror vs any objective measurements (there are really easy improvements possible here)

tl;dr - if you swapped Estriol with "scalp massages" in that approach, nobody would accept this as evidence they work (nor should they)
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I disagree that it makes it worse because your initial claim was that his gains were from topical dutasteride - I'm saying that's less likely due to him coming off a stronger treatment for a weaker one of the same MOA.

Sure it could be that more time on 5ARI are the cause for his regrowth (which was very significant, I've seen pictures), but like I said earlier it's not unreasonable to claim E3 may have had a significant impact here given these factors
 
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pegasus2

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Jackshtbro said:
I disagree that it makes it worse because your initial claim was that his gains were from topical dutasteride - I'm saying that's less likely due to him coming off a stronger treatment for a weaker one of the same MOA.

Sure it could be that more time on 5ARI are the cause for his regrowth (which was very significant, I've seen pictures), but like I said earlier it's not unreasonable to claim E3 may have had a significant impact here given these factors
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You're wasting your breath. This guy could watch someone get run over by a train and he'd say "it's presumptuous to say the train was the cause of death before doing a full autopsy".
 
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jamesbooker1975

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Redgate said:
Usually the components in a sample are separated using HPLC and then other methods like NMR or MS are used to confirm the chemical identity of each component.
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To use HPLC you need to compare it with a " patron Drug " . That is , a sample of a the know pure drug. Again, I highly doubt any USA lab have a patron of RU .
 
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Redgate

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jamesbooker1975 said:
To use HPLC you need to compare it with a " patron Drug " . That is , a sample of a the know pure drug. Again, I highly doubt any USA lab have a patron of RU .
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No you don't. No comparison against a "known pure sample" takes place whatsoever. HPLC is a process to separate the different components in a mixture and in a pure sample it will show a single spike in the chromatogram. NMR/MS are used to identity the component. MS for example gives you the molecular weight which can be compared to the one calculated from the molecular formula of the component.
 
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notoriousone

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Redgate said:
No you don't. No comparison against a "known pure sample" takes place whatsoever. HPLC is a process to separate the different components in a mixture and in a pure sample it will show a single spike in the chromatogram. NMR/MS are used to identity the component. MS for example gives you the molecular weight which can be compared to the one calculated from the molecular formula of the component.
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How would I go about testing purity of something like CB from a lab in the US? What would be the test I would use?
 
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Dr sanches

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