There is far more evidence for RU working then there is for AR upregulation (there is no evidence of AR upregulation). Lots of people have gotten results on RU, mainly the one's that have used it properly at 50mg x2 daily application or higher and don't have very aggressive loss. There is an inherit bias for people who post on forums to be the one's that didn't get results.Actually, there is a noted lack of RU results. If you google previous posts about RU on this forum, you'll see that people have been lamenting lack of evidence/results of RU for years now. Only that MPMD guy (who gets commissions on RU sales) seems to have gotten great results.
Well, I don't want to derail this thread by talking about RU too much, but the AR upregulation is still a genuine concern. As you say, though, pyrilutamide is a lot more efficacious than RU so it might be able to have long-term results.