Kintor has started Phase 3 trial in China for Pyrilutamide

Cardinal~

New Member
My Regimen
Reaction score
4
Yeah wasnt there some results expected to come out before the end of 2021? What happened to them?
 

5minutesbeforemiracle

Established Member
My Regimen
Reaction score
153
Some have theorised that CB wasn't as effective at 12 months compared to 6 months due to AR-upregulation when using AA. Pyrilutamide phase 3 study is only 6 months so we can't know for sure if something similar will happen here. Does anyone have any theories?
 

Kagaho

Experienced Member
My Regimen
Reaction score
711
Some have theorised that CB wasn't as effective at 12 months compared to 6 months due to AR-upregulation when using AA. Pyrilutamide phase 3 study is only 6 months so we can't know for sure if something similar will happen here. Does anyone have any theories?

Not likely. RU users (and macaque studies corroborates that) have reported long lasting benefits from it and both have the same MOA.

Pyrilutamide binding affinity to AR is like 4x RU so i wouldnt expect that to happen. CB may just not be potent enough to hold the gains.
 
Last edited:

fashy

Established Member
My Regimen
Reaction score
175
This 1 year delay of the results + the lack of information or action in regards to the phase II FDA trial (considering the trial was greenlit last June and Kintor usually moves much faster than this) has me just slightly worried. Hopefully it's nothing significant.
 

5minutesbeforemiracle

Established Member
My Regimen
Reaction score
153
Not likely. RU users (and macaque studies corroborates that) have reported long lasting benefits from it and both have the same MOA.
Actually, there is a noted lack of RU results. If you google previous posts about RU on this forum, you'll see that people have been lamenting lack of evidence/results of RU for years now. Only that MPMD guy (who gets commissions on RU sales) seems to have gotten great results.
Well, I don't want to derail this thread by talking about RU too much, but the AR upregulation is still a genuine concern. As you say, though, pyrilutamide is a lot more efficacious than RU so it might be able to have long-term results.
 

trialAcc

Senior Member
My Regimen
Reaction score
1,537
Actually, there is a noted lack of RU results. If you google previous posts about RU on this forum, you'll see that people have been lamenting lack of evidence/results of RU for years now. Only that MPMD guy (who gets commissions on RU sales) seems to have gotten great results.
Well, I don't want to derail this thread by talking about RU too much, but the AR upregulation is still a genuine concern. As you say, though, pyrilutamide is a lot more efficacious than RU so it might be able to have long-term results.
There is far more evidence for RU working then there is for AR upregulation (there is no evidence of AR upregulation). Lots of people have gotten results on RU, mainly the one's that have used it properly at 50mg x2 daily application or higher and don't have very aggressive loss. There is an inherit bias for people who post on forums to be the one's that didn't get results.
 

Roeysdomi

Experienced Member
My Regimen
Reaction score
296
There is far more evidence for RU working then there is for AR upregulation (there is no evidence of AR upregulation). Lots of people have gotten results on RU, mainly the one's that have used it properly at 50mg x2 daily application or higher and don't have very aggressive loss. There is an inherit bias for people who post on forums to be the one's that didn't get results.
Hard to find results of RU … rare very rare.
 

BigBadBaldie

Member
My Regimen
Reaction score
33
There’s too many variables to get any definitive idea online of if RU58841 works. First of all most people are buying it from the same few vendors who could be selling old/underdosed/something completely different to RU58841. This isn’t an approved pharmaceutical so there’s no standardisation of anything. On top of that people are applying it in different vehicles, storing it in different ways and using it at different intervals. On top of that the few people claiming it works are people already using finasteride and minoxidil to further complicate things. Many people are just dumping it in minoxidil bottles yet we don’t know if these compounds react or not. I think it’s a complete waste of money to be honest, I like MPMD but as previously mentioned he has affiliate links to these companies also, so even his results are questionable (and even he is using finasteride now). On top of that we have exactly 0 human studies available to us to show its effectiveness/safety. Oh and I used it personally before anyone asks and it did nothing for me.
 

Baldingtooyoung

Established Member
My Regimen
Reaction score
114
There’s too many variables to get any definitive idea online of if RU58841 works. First of all most people are buying it from the same few vendors who could be selling old/underdosed/something completely different to RU58841. This isn’t an approved pharmaceutical so there’s no standardisation of anything. On top of that people are applying it in different vehicles, storing it in different ways and using it at different intervals. On top of that the few people claiming it works are people already using finasteride and minoxidil to further complicate things. Many people are just dumping it in minoxidil bottles yet we don’t know if these compounds react or not. I think it’s a complete waste of money to be honest, I like MPMD but as previously mentioned he has affiliate links to these companies also, so even his results are questionable (and even he is using finasteride now). On top of that we have exactly 0 human studies available to us to show its effectiveness/safety. Oh and I used it personally before anyone asks and it did nothing for me.
Tbh, if you look on the Good Looking Loser forum. You'll see his account (just) before he started YouTube. He mentions that since he used RU (per recommendation of Chris, the admin) he barely loses any hair with it anymore while blasting steroids.
So the whole affiliate link is just a BS story imo. You'll see him log about how he experiments with Tren and Mast and still barely loses hair. Even when he was -5K followers he was an big promoter on RU58841. He has an amazing before after as well that is well logged.
There is no reason to not believe him.
 

trialAcc

Senior Member
My Regimen
Reaction score
1,537
There’s too many variables to get any definitive idea online of if RU58841 works. First of all most people are buying it from the same few vendors who could be selling old/underdosed/something completely different to RU58841. This isn’t an approved pharmaceutical so there’s no standardisation of anything. On top of that people are applying it in different vehicles, storing it in different ways and using it at different intervals. On top of that the few people claiming it works are people already using finasteride and minoxidil to further complicate things. Many people are just dumping it in minoxidil bottles yet we don’t know if these compounds react or not. I think it’s a complete waste of money to be honest, I like MPMD but as previously mentioned he has affiliate links to these companies also, so even his results are questionable (and even he is using finasteride now). On top of that we have exactly 0 human studies available to us to show its effectiveness/safety. Oh and I used it personally before anyone asks and it did nothing for me.
Lots of people have results with RU, the people saying otherwise are the people who craft their opinions without taking into account the bias of the posts that claim lack of results. Most people turn to RU out of desperation when finasteride and dutasteride are not working anymore, expect miracles and like you said, have a million variables including their own consistency that go into it's efficacy.

There are enough examples of people who only use RU and get visible results to know that it does work in some capacity. I just don't think it's strong enough to move the needle for the people who need it the most and have exhausted other options.
 

Baldingtooyoung

Established Member
My Regimen
Reaction score
114
Lots of people have results with RU, the people saying otherwise are the people who craft their opinions without taking into account the bias of the posts that claim lack of results. Most people turn to RU out of desperation when finasteride and dutasteride are not working anymore, expect miracles and like you said, have a million variables including their own consistency that go into it's efficacy.

There are enough examples of people who only use RU and get visible results to know that it does work in some capacity. I just don't think it's strong enough to move the needle for the people who need it the most and have exhausted other options.
I am trying a RU regiment now for at least one year. I use steroifs as well so jt should be more effective (based on anectodatl reports). I will update this threas
 

BigBadBaldie

Member
My Regimen
Reaction score
33
Tbh, if you look on the Good Looking Loser forum. You'll see his account (just) before he started YouTube. He mentions that since he used RU (per recommendation of Chris, the admin) he barely loses any hair with it anymore while blasting steroids.
So the whole affiliate link is just a BS story imo. You'll see him log about how he experiments with Tren and Mast and still barely loses hair. Even when he was -5K followers he was an big promoter on RU58841. He has an amazing before after as well that is well logged.
There is no reason to not believe him.
Yeah RU worked so well for him that he no longer uses it and had to get a hair transplant…
 
Top