HMI-115 PRLR antibody: The Most Promising Treatment Ever

sunlight2

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Yep, just a few pages he was vehemently arguing for the regrowth properties of Pyri.
 
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dani500

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you have raised our expectations a lot, and now you say this, you are a sadist my friend
dutasteride and pyril are enough for lifetime maintance. If you value your hair (that much) you would sacrifice your dick for hair, like depressed people sacrifice dick for their happiness.
 

pegasus2

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you have raised our expectations a lot, and now you say this, you are a sadist my friend
We are all disappointed with the results of HMI, but adults take things in stride.
Maybe it will be synergistic with microneeling, since HMI doesn't appear to work as well on slick bald areas
 

Hazelboy98

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We are all disappointed with the results of HMI, but adults take things in stride.
Maybe it will be synergistic with microneeling, since HMI doesn't appear to work as well on slick bald areas
Isn't it injected subcutaneously in the abdomen? I don't think microneedling will make much of difference. Nevertheless an alternative to finasteride is still a significant win in my book, only like a 100,000 - 200,000 american men use finasteride specifically for hairloss. Vast majority of finasteride's userbase is for prostate issues alone, very few men actually do anything about their balding
 

pegasus2

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Isn't it injected subcutaneously in the abdomen? I don't think microneedling will make much of difference. Nevertheless an alternative to finasteride is still a significant win in my book, only like a 100,000 - 200,000 american men use finasteride specifically for hairloss. Vast majority of finasteride's userbase is for prostate issues alone, very few men actually do anything about their balding
Microneeling is not about increasing absorption. It even works without any drug at all. Wounding does a lot of things like recruiting Wnt secreting macrophages.
 

coolio

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dutasteride and pyril are enough for lifetime maintance. If you value your hair (that much) you would sacrifice your dick for hair, like depressed people sacrifice dick for their happiness.

Except the main point of having hair is to improve your chances to use your dick.
 

llbesh

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We are all disappointed with the results of HMI, but adults take things in stride.
Maybe it will be synergistic with microneeling, since HMI doesn't appear to work as well on slick bald areas
What results? Could you please share a link?
AFAIK HMI-115 just started Stage 2 trials, and you were defending the treatment just 2 pages before. What have changed?
 

pegasus2

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What results? Could you please share a link?
AFAIK HMI-115 just started Stage 2 trials, and you were defending the treatment just 2 pages before. What have changed?
Nothing has changed. The results are good, but they aren't as good as the macaques based on what we've seen from one patient. We are still waiting for their hair count numbers from phase I to have a better idea
 

acbrantlin

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2 patients* His wife was also in the 16 person trial and he said she did not get as good results as he did (aka she got no results).

And she has no bald patches, so if she didn't improve thickness in non-bald areas, then it's not looking good. The only cope left would be that its mechanism is only effective in men, which is unlikely. But it's telling that Hope is only trialing men in phase 2 and not women.
 

coolio

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I didn't know they had dropped trialing women in the next round.

That doesn't bode well.
 

peladillo peach

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That is not really the case, the influence of prolactin on alopecia is much more relevant in the case of women than in men. In all clinical trials, companies are much more reluctant to include women than men due to legal issues (pregnancies...), that does not mean it doesn't work. Furthermore, they are going to start this same treatment in women for endometriosis, which in the case of women is closely related to alopecia.
 

acbrantlin

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That is true, it would be pointless to have women in the hair trial since they're doing a women-only endometriosis phase 2 trial and can glean hair info from that.
 

Otrebor

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Is it possible that this reddit patient is a liar or just taking the placebo?

I hope one of these things, or something similar. Otherwise it's over, after this treatment it's seriously over
 

acbrantlin

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Is it possible that this reddit patient is a liar or just taking the placebo?

I hope one of these things, or something similar. Otherwise it's over, after this treatment it's seriously over

He's not lying, he's simply dumb. There are hundreds of people on this very forum that have taken every experimental drug under the sun and they look in the mirror within a week of taking it and are convinced that they see new hairs sprouting, which obviously is physiologically impossible.

There are so many factors that contribute to this phenomenon, but there's no malice. It's simply delusion and a lack of critical thinking skills.
 

Hairismylife

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He's not lying, he's simply dumb. There are hundreds of people on this very forum that have taken every experimental drug under the sun and they look in the mirror within a week of taking it and are convinced that they see new hairs sprouting, which obviously is physiologically impossible.

There are so many factors that contribute to this phenomenon, but there's no malice. It's simply delusion and a lack of critical thinking skills.

He did have regrowth, if you think otherwise you are delusional.
 

pegasus2

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That is not really the case, the influence of prolactin on alopecia is much more relevant in the case of women than in men. In all clinical trials, companies are much more reluctant to include women than men due to legal issues (pregnancies...), that does not mean it doesn't work. Furthermore, they are going to start this same treatment in women for endometriosis, which in the case of women is closely related to alopecia.
In macaques the men responded much better than the females
 

acbrantlin

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He did have regrowth, if you think otherwise you are delusional.
Okay fine I'll admit that he went from roughly norwood 6 to about norwood 6.

Unless you're referring to the pictures where he went from norwood 6 to norwood 3? The ones where his entire head is very clearly painted with fibers? Which he admitted to using? If you count fibers then yea he got a ton of regrowth. If you don't count fibers then he got no regrowth.
 

pegasus2

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Okay fine I'll admit that he went from roughly norwood 6 to about norwood 6.

Unless you're referring to the pictures where he went from norwood 6 to norwood 3? The ones where his entire head is very clearly painted with fibers? Which he admitted to using? If you count fibers then yea he got a ton of regrowth. If you don't count fibers then he got no regrowth.
According to the investigators he was NW4 to begin with, and went to NW3. Lay people always exaggerate norwoods.

By the way, did you see that pyrilutamide failed? Kevin Mann said it would be the cure
 
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