HMI-115 PRLR antibody: The Most Promising Treatment Ever

acbrantlin

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According to the investigators he was NW4 to begin with, and went to NW3. Lay people always exaggerate norwoods.

By the way, did you see that pyrilutamide failed? Kevin Mann said it would be the cure

His 2023 photos seem like norwood 6 to me, but I do see a lot of differences in norwood scales across the internet. On some he's norwood 4 and on others he's norwood 6.
1701059370270.png

On this he's definitely norwood 6. It's possible they judged him as 4A on this scale, but to me his hair is nowhere near dense enough to warrant that. Either way he's Norwood 6 as late as June 2023.

I also did not see that pyrilutamide failed. I wasn't following it closely, but I do recall that there was a particularly... eccentric person on this forum that was using it and he was convinced it worked amazing for hair, but also that somehow his dick stopped working within 24 hours of taking it. So it was hard for me to take it seriously.

But yeah that's really unfortunate. Because that was one of the bigger names of potential future treatments. Top 3 even.
 

coolio

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The Norwoods are just a visual description. IMO it would be more useful if people described it with stages. "He's a current NW3 with visible Norwood#6 thinning."


As for Pyrilutamide?

It's an androgen-fighting method. We already know the limits of that whole general approach. If chemical castration doesn't even regrow much lost hair, then it's pointless to hope for more results than that from less severe drugs.

Blocking/reducing androgens is only good for slowing down future hair loss. Period. Whatever regrowth it generates is a mild rebound effect in follicles that went bald more recently so they were still hanging by a thread.
 
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llbesh

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By the way, did you see that pyrilutamide failed?
Pyrilutamide finished stage II trials in US with +10hair/cm and started and completed subject enrolment in phase III in China.
Are you talking in terms of pyralitamide being/not being a miracle drug?
"pyralitamide failed" for me means it can not block DHT receptors at all/sides overweight the effect.
 

nick123

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Pyrilutamide finished stage II trials in US with +10hair/cm and started and completed subject enrolment in phase III in China.
Are you talking in terms of pyralitamide being/not being a miracle drug?
"pyralitamide failed" for me means it can not block DHT receptors at all/sides overweight the effect.

These are the phase 2 results that Kintor shared for Pyrilutamide:

1701087603413.png


Placebo BID was around 7 TAHC cm2
5mg BID was around 22 TAHC cm2

22 - 7 = 15 TAHC cm2 when comparing change versus placebo at 6 months.

What would be more interesting in my opinion is to know whether Pyrilutamide looses efficacy after 6 months similar to clascoterone (CB-03-01).

Once the phase 3 results are out, which should be any day now that should tell us more but for now I'd suggest sticking to RU.
 
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peladillo peach

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Estos son los resultados de la fase 2 que Kintor compartió para la pirilutamida:

[ADJUNTAR=completo]185845[/ADJUNTAR]

El placebo BID fue de aproximadamente 7 TAHC cm2
5 mg dos veces al día fue de alrededor de 22 TAHC cm2

22 - 7 = 15 TAHC cm2 al comparar el cambio versus placebo a los 6 meses.

Lo que sería más interesante en mi opinión es saber si la pirilutamida pierde eficacia después de 6 meses de manera similar a la clascoterona (CB-03-01).
Acaba de salir una declaración de Kintor sobre la fase 3... y sí, falló.
 

dkdkl

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These are the phase 2 results that Kintor shared for Pyrilutamide:

View attachment 185845

Placebo BID was around 7 TAHC cm2
5mg BID was around 22 TAHC cm2

22 - 7 = 15 TAHC cm2 when comparing change versus placebo at 6 months.

What would be more interesting in my opinion is to know whether Pyrilutamide looses efficacy after 6 months similar to clascoterone (CB-03-01).

Once the phase 3 results are out, which should be any day now that should tell us more but for now I'd suggest sticking to RU.

They have just came out with a press release on this (phase 3) , check out the new thread in the research section
 

pegasus2

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Pyrilutamide finished stage II trials in US with +10hair/cm and started and completed subject enrolment in phase III in China.
Are you talking in terms of pyralitamide being/not being a miracle drug?
"pyralitamide failed" for me means it can not block DHT receptors at all/sides overweight the effect.
No, their Phase III was announced already. It didn't meet statistical significance. They will have to redo it with a longer duration and higher N, or abandon the drug. It just isn't very good.
 

soull

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I have always been cautious, but I must rule out Kintor. In his latest statement they have issued a warning about investing in his company. Therefore that means that we do not expect anything.

I think HMI is going the same way.

good luck to everyone.
 

acbrantlin

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Given Hope's eagerness to partner with a manufacturing company for commercialization, it looks like they're planning on shipping it out regardless of its results in humans. They already have amazing marketing material with the stump-tailed macaque trial alone. Minoxidil also had a stump-tailed macaque trial show positive results the same year it came to market in 1986, so they have an easy minoxidil comparison too. That's really all you need to successfully sell a hair loss product. Plenty of cosmetic hair loss products that have been proven to do nothing still fly off the shelves because of good marketing. As far as drugs, it has much a better marketing profile than PRP and somehow PRP is still thriving in dermatologists' treatment repertoire. Which I'd argue is only because those useless and clueless mfers get off on the $ervice charge of the injections. Which funnily enough would also apply to HMI-115. So I'd put money on it releasing, effective or not.
 

Otrebor

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Baldness is truly an ineradicable curse. Now we are able to do more or less anything, but baldness remains unbeatable. No one has ever undertaken to connect the dots, try to intertwine all the possible paths and trace back to a possible path to hit with all the forces. it's really "amazing", it seems that so many genes and pathways regulate something as simple as hair in humans. HMI seemed promising thanks to the experiments on macaques but apparently it will be yet another bullshit, and this for three generations. I hope that this reddit user is a liar, or a placebo... if this were not to be the case it would mean that this thing is literally incurable, either due to the complexity, or due to the absolute incompetence of the scientists, lack of real will.

As usual we find ourselves counting the hairs, which are now even higher in number than the disappointments. For goodness sake I have nothing to say, in fact I respect the reckless and the people who are constant in their treatment. Unfortunately, I'm not like that, all or nothing. And apparently we should resign ourselves again.


ps: the last possibility is that the treatment is still at very low doses or that it requires even more time, we are really waiting for the results even if all this waiting doesn't give me hope in any case. What an endless odyssey.
 

pegasus2

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Calm down. There are other options. It can be cured, and if we don't already know how then we soon will.
 

ppma

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It amazes me how people are already claiming this is another BS even without the results having been released.

They've gone towards making partnerships for commercialization already. This won't be a cheap topical, it's a synthetic antibody that will cost 1000s of dollars. Going mass production without solid background that it works is a suicide.

Moreover, the most interesting thing is to prove that the PRLR is one of the main mediators. Supposed this premise is proven true, this opens up new research that will have much better odds to yield reliable treatments than the current approaches.
 

coolio

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It amazes me how people are already claiming this is another BS even without the results having been released.

They've gone towards making partnerships for commercialization already. This won't be a cheap topical, it's a synthetic antibody that will cost 1000s of dollars. Going mass production without solid background that it works is a suicide.

Moreover, the most interesting thing is to prove that the PRLR is one of the main mediators. Supposed this premise is proven true, this opens up new research that will have much better odds to yield reliable treatments than the current approaches.

If HMI is a viable product for endometriosis, then that alone justifies the up-front investment to mass-produce it. And that will cheapen the stuff to some extent.

But if the drug doesn't regrow any more hair than this 'Moeman' trialist shows, then it's fair to call it another frustrating disappointment. We didn't start paying attention to this stuff hoping for another Propecia. We were hoping for some actual progress and the macaque results seemed to promise that.

If HMI is another Propecia then I'm glad to have it and I'm also really f*****g disappointed that it wasn't more. Anybody who gripes at other forum members for that attitude has no emotional intelligence. Hair loss treatments are not sports teams. It's ridiculous the way people get so tribal about them around here. (FFS, you'd think going bald would have some correlation with maturity.)

Bottom line - we still don't know the situation with HMI until we see the data results from the stage-2 trial.
 

Get my hair back

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Elixirs from all diseases were successfully sold in different centuries and for this purpose it was not necessary any strong proofs, it was enough to let a rumor and to cure a couple of lame koleks on display)). Not much has changed now. The main thing would be the demand, and how to divorce methods will be found.
I'm afraid we will get the same sh*t, like propecia, only in a new package.
 

pegasus2

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If HMI is a viable product for endometriosis, then that alone justifies the up-front investment to mass-produce it. And that will cheapen the stuff to some extent.

But if the drug doesn't regrow any more hair than this 'Moeman' trialist shows, then it's fair to call it another frustrating disappointment. We didn't start paying attention to this stuff hoping for another Propecia. We were hoping for some actual progress and the macaque results seemed to promise that.

If HMI is another Propecia then I'm glad to have it and I'm also really f*****g disappointed that it wasn't more. Anybody who gripes at other forum members for that attitude has no emotional intelligence. Hair loss treatments are not sports teams. It's ridiculous the way people get so tribal about them around here. (FFS, you'd think going bald would have some correlation with maturity.)

Bottom line - we still don't know the situation with HMI until we see the data results from the stage-2 trial.
FWIW they did not get results from the endo trial yet. They made the manufacturing agreement after the hair loss trial ended.
 

Alec708

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This whole thing is just so fricken crazy. It's almost 2024 for heaven's sake. What happened to all the big names we use to hear about 15-20 years ago. People like Cotsarelis, Washenick, Christiano, etc.. They were all so passionate about finding a final solution to hair loss/baldness. Did they fall of the edge of the Earth? Did someone hand them a large check under the table? The fact that we are in a time of near AGI and still using drugs from the 80s and 90s, found by accident, is just nuts!!
 

dani500

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If HMI is a viable product for endometriosis, then that alone justifies the up-front investment to mass-produce it. And that will cheapen the stuff to some extent.

But if the drug doesn't regrow any more hair than this 'Moeman' trialist shows, then it's fair to call it another frustrating disappointment. We didn't start paying attention to this stuff hoping for another Propecia. We were hoping for some actual progress and the macaque results seemed to promise that.

If HMI is another Propecia then I'm glad to have it and I'm also really f*****g disappointed that it wasn't more. Anybody who gripes at other forum members for that attitude has no emotional intelligence. Hair loss treatments are not sports teams. It's ridiculous the way people get so tribal about them around here. (FFS, you'd think going bald would have some correlation with maturity.)

Bottom line - we still don't know the situation with HMI until we see the data results from the stage-2 trial.
haha nicely written, most people here are basement/bed ridden and have no touch with reality.
 

pegasus2

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These are the phase 2 results that Kintor shared for Pyrilutamide:

View attachment 185845

Placebo BID was around 7 TAHC cm2
5mg BID was around 22 TAHC cm2

22 - 7 = 15 TAHC cm2 when comparing change versus placebo at 6 months.

What would be more interesting in my opinion is to know whether Pyrilutamide looses efficacy after 6 months similar to clascoterone (CB-03-01).

Once the phase 3 results are out, which should be any day now that should tell us more but for now I'd suggest sticking to RU.
The placebo QD group grew 12 hairs it looks like, so 5mg BID was about 11 hairs more than placebo QD. That is terrible compared to finasteride, which I think is 23 hairs?

Instead of cherry-picking which placebo group to go with as they did, it makes sense to average them together. Then you get around 10 hairs. That makes the 5mg BID cohort look a little better at about 13 hairs over placebo, but still well behind finasteride.

Another way you could look at is to average all treatment groups and both placebo groups. Then it looks like you get about 19 hairs in the treatment group, and 10 hairs in the control group, so you gained 9 hairs with pyrilutamide. That's better than Follicum, but still terrible.
 
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