CPA at 12.5mg ED is not low dose. A Diane 35 pill gets you 2mg of cypro and that's still not low dose. Why people can't do more studies before saying things like that?
Sure, 12.5mg is enough for transwomans but in conjuction with E2.
CPA monotherapy is not going to lower your testosterone levels to FEMALE RANGES, even with high doses. Only CPA + E2 is going to lower testosterone to female ranges so I think that you should do more studies.
Oral CPA has been studied at low dosages of 5 to 20 mg/day as a potential
male hormonal contraceptive.
[132][133] A dosage of as low as 5 to 10 mg/day oral CPA has been found to suppress circulating testosterone levels in men by 50 to 70%.
[134][119][135][136] For comparison with lower dosages, the suppression of circulating testosterone levels in men with a dosage of 100 mg/day oral CPA was 77% and with a dosage of 300 mg/week intramuscular CPA was 76%.
[137][138] Dosages of CPA of 12.5 to 25 mg/day have been used as a maintenance dosage for testosterone suppression in men with sexual deviance after initial administration of higher CPA dosages, without recurrence of symptoms.
[139][140] CPA is generally able to maximally suppress circulating testosterone levels by 70 to 80% in men.
CPA has been found to be effective in the treatment of acne in males, with marked improvement in symptoms observed at dosages of 25, 50, and 100 mg/day in different studies.[52][53][54][55] It can also halt further progression of scalp hair loss in men.[56][57][58] Increased head hair and decreased body hair has been observed with CPA in men with scalp hair loss.[59][13] In addition, lower dosages of CPA, such as 25 mg/day, have been found to be better-tolerated in men.[54]
Source:
https://en.m.wikipedia.org/wiki/Cyproterone_acetate
Btw. I dont want to be a Fabio. I just want to stop my hairloss especially on the sides/back of head, so I can wear a hairsystem for a longer time. Maybe I am wrong but I strongly believe that lowering androgens levels at least slow down hairloss. I dont expect regrowth.
Its same as with Finasteride/Dutasteride, this drugs lower DHT levels and a lot of people develop regrowth/stopped hairloss while taking it (unfortunately not me). Its same with CPA, its lowering testosterone as well as DHT so I think Its worth to try if finasteride/dutasteride/minoxidil/RU doesnt work.
Im just trying it... If it wont help, then Im going to withdraw it, I dont see the problem. Each person is different and reacts to something else. One can benefit with healthy diet the other with finasteride only and another one with Cyproterone Acetate and another one with HRT.