Possible explanation why people still lose hair while nuking his DHT to literally 0:
Pretty interesting. Includes an explaination of why some castrated people still go bald.
This guy ran 1g of oral dutasteride for a year daily, 0 DHT serum levels and still was losing hair. Looks like he loses ground if not on RU. Right now he's maintaining well with this regime:
The problem with using RU is that im not sure about how safe it is. I've heard that it can reach the heart... alternatives would be CB and spironolactone, but that aren't any more tested than RU is for hairloss.
Im going to start doing mesotherapy with dutasteride (inject directly on the scalp), however, clinics only do it once monthly. There's a study with good results once every 3 months which is puzzling.. how would a single dutasteride injection give good results? by the second month the drug would have decayed a lot isn't it? Unless by injecting it it lasts longer than oral ingestion I have no idea.
My experiment would be to use mesotherapy while I continue with the usuals (which aren't working as good anymore, if they ever did, that is topical finasteride and minoxidil) and add mesotherapy with dutasteride. Would consider low dose oral dutasteride, however, if male pattern baldness is a local problem on the scalp, I don't see why one would need to nuke all androgens systematically. Why do we go bald? because the androgens reach the scalp tissue. So wouldn't it make sense to just act locally? In this sense, injecting the dutasteride directly on the scalp seems like the best way to go about it... I can't inject an AR antagonist tho.. so I would need to use RU/spironolactone/CB... but like I said before im concerned about unknown sides, plus you are trusting some random chinese lab... good times. There's also the risk of upregulation of the receptors. Think about it: How safe would be that one inhibits a receptor chronically? What if using these compounds make you more sensitive to androgens eventually? Inhibiting the enzyme seems safer than inhibiting the receptor, chronically, and male pattern baldness is a chronic problem.. so this is a dead end if true.
Note that im not interested in the whole trans thing. Im a man and must stay a man, a man with hair. Anything else is a scam.