Good post Enden. I have a final three questions for you Dr. Crisler. Please take your time and answer i think these are critcial. Firstly, where you do find that a person has increased reductase I activity (either via THF/5-a-THF, or AN/ET, and/or serum/urine DHT testing) ...what next? I spoke of this to my endo and he said there's an old saying in medicine alone the lines of "if you dont know what to do with the results, the test itself isn't worth taking". Is this the case here? In relation to this, i have read that an increase in free testosterone levels can help 3-adiol-G levels so that may be connected somehow. Secondly, do you believe Cortisol levels are an important factor here or not? Are you seeing any trend whereby your PFS patients exhibit low cortisol levels. Lastly, are you are all interested in the low vitamin D levels alot of people on propecia help seem to have?