Darolutamide (odm-201), A Better Topical Than Enzalutamide? | Page 46 | HairLossTalk Forums

Darolutamide (odm-201), A Better Topical Than Enzalutamide?

Discussion in 'Antiandrogens - Propecia, Dutasteride, etc.' started by JLF, May 4, 2017.

  1. Georgie

    Georgie Senior Member My Regimen

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    My hair in the worst shape it’s ever been. I’ve been on this shit since the beginning of January, fresh batches. It’s getting to a point where I’m thinking of shaving it just so I don’t have to see it get worse from day to day. All I feel is scalp all over my head. Even if this shit grows some hair back, there’s almost no coming back from the amount of damage that’s been done. Fucking fuckity fuck why?!
     
  2. Murkey Thumb

    Murkey Thumb Experienced Member My Regimen

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    There are a lot of false flags on this site, in the end the big 3 + transplant is all we got.
     
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  3. SteveTabernack

    SteveTabernack Experienced Member My Regimen

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    As frustrated as I am I still think that comparison is unfair. How many people have actually tried this, like 6? RU users is in the thousands. Also, we should keep in mind that no one besides ideal has even reached the three month mark I think?
     
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  4. Georgie

    Georgie Senior Member My Regimen

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  5. Georgie

    Georgie Senior Member My Regimen

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    We have to consider that we are not looking at castration doses, but enough to inhibit androgen receptivity significantly at a topical level. Fina is dosed 5-10x higher for bph, flutamide and bical are 3-4x greater. Point is we aren’t trying to nuke our androgens totally, but find a sweet spot. I myself apply 10mg daily. Maybe you are right, but it’s folly to jump headlong into super high doses without trialing the lower ones for at least 6 months.
     
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  6. jonnywalker93

    jonnywalker93 Established Member My Regimen

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    Be careful guys this shit is really strong...

    I was quite desperate yesterday and mixed a batch with twice the amount of Daro (60mg Daro, 15ml PG, 10ml ethanol, 5ml water). Applied 2ml and struggle with erections now. Had some balls ache over the day as well (not very intense though).
     
  7. Georgie

    Georgie Senior Member My Regimen

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    Ahhh usually the symptoms are skin and eye dryness, potentially anxiety and headaches, flu-like symptoms. Haven’t heard of fina type symptoms with daro. Those aren’t even listed on the drug info.
     
  8. whatevr

    whatevr Senior Member My Regimen

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    Lol. What do you think happens Georgie, when a super-strong androgen receptor inhibitor attaches to the androgen receptors in a guy's dick? That kinda shit.

    It'll lose ability to get arousal signals from the brain and to be able to get erect, just like you nuked those same receptors in the brain and killed libido completely.
     
  9. Georgie

    Georgie Senior Member My Regimen

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    I just find it odd that it’s not described as one of the main side effects in drug trials, but I’m always willing to be proven wrong. It may be the case indeed that @jonnywalker93 is experiencing these sides from the daro. @jonnywalker93 Are you on any other AA’s?

    Ps my shedding is still off th charts and now any hair that grows around my face is miniturised. Avo/daro ain’t doing shit.
     
  10. Georgie

    Georgie Senior Member My Regimen

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    Oh ps everyone I’ve been reading tons of studies about topical estrogen therapy in Androgenetic Alopecia and I’m gonna trial a home made solution with crushed b-estrgoen tabs I got on prescription from my gyn. Dissolved at 2.5mg/ml ethanol and 20mg/ml dmso. Maybe just dump 2mg in 4ml minoxidil. Hopefully I don’t grow tits on my forehead.
     
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  11. whatevr

    whatevr Senior Member My Regimen

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    Shit, at least you don't have to worry about gyno like us guys do. You might get a bonus that your tits get larger. Win/win.
     
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  12. sunchyme1

    sunchyme1 Senior Member My Regimen

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    yeah good point man ^

    @Georgie if your not sure your getting this side effect you can always pm me some before/afters

    i will confirm
     
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  13. jonnywalker93

    jonnywalker93 Established Member My Regimen

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    Well the drug castrates you, so an adverse effect on the sexual function is inevitable I reckon.

    In terms of other AA, I dropped finasteride a while ago (too long ago to have any impact). Brain fog and heart rate increase were the reason.

    Hang in there, at least you see some regrowth. Is it the minoxidil that helps?
     
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  14. Georgie

    Georgie Senior Member My Regimen

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    Only the forehead tits
     
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  15. Georgie

    Georgie Senior Member My Regimen

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    I’ve been on Diane and avodart now for a while. My boobs aren’t doing shit. I am literally the most unlucky motherfucker on the planet when it comes to hormones.
     
  16. SteveTabernack

    SteveTabernack Experienced Member My Regimen

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    Wow my hair loss has gone berserk. Looks so shit and shedding is out of control. It's literally making me sick to my stomach.

    I don't know whether to stop this crab or ride it out... or if it even matters and my disease was always gonna progress like this.
     
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  17. whatevr

    whatevr Senior Member My Regimen

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    Yeah I'm sorry mate. Antiandrogens are primitive. I had increased hair loss on Finasteride actually. You need to look into other avenues this clearly isn't going to work out for you. Insane shedding always ends up badly in my experience, it never comes back and never leads to any kind of miracle regrowth.
     
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  18. SteveTabernack

    SteveTabernack Experienced Member My Regimen

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    Fuck man what other avenues are there? Setipiprant? Does not look promising at all to me. What do you think?

    I've legit started thinking whether hair system will be my route. What a nightmare.
     
  19. whatevr

    whatevr Senior Member My Regimen

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    Yeah PGD2 inhibitors, maybe try that shit. What's to lose?

    Maybe Brotzu.
     
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  20. Georgie

    Georgie Senior Member My Regimen

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    Yeah same. I’ve also been getting weird flu like symptoms for the past 2 weeks and I feel like 200% dog shit. May or may not be connected, but I’m also getting very dry eyes, headaches and photophobia.
     

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