- Reaction score
- 2,616
yes the hirutism I know about, and I should have noted that, but penetration into the abdomen is alot harder than the scalp so it makes sense that it didnt penetrate deep enough to have an effect and they didnt mention any microneedling either...but still who said it was enough to block scalp DHT and not serum DHT to keep or regrow hair? moreplatesmoredates said that ORAL dutasteride outperformed topical dutasteride and even mesotherapy, so this proves that only reducing local DHT may not be enough for some people. Atm I have only heard about mustang and sonictemples on this thread that have had results. so yeah. and more and more people dont even trust mustang anymore.I wouldn't draw that conclusion based on that study:
Our study suggests that topical application of finasteride does not result in significant systemic absorption. Despite daily application of 2.5–5 mg of topical finasteride, there was no increase in circulating testosterone or decrease in DHT levels over 6 months.
They hypothesize topical finasteride doesn't work because they had no results. But they also saw almost no systemic absorption. This seems to bring them to the conclusion that inhibiting 5-alpha-reductase locally has no effect, but also that topical finasteride doesn't systemically absorb.
But they don't know whether they even inhibited 5-alpha reductase locally. It's unlikely because we already know that applying finasteride topically to the scalp results in significant systemic absorption, reducing circulating dht levels. Studies show it and our own experiences show it. The much more likely answer is that their finasteride didn't reach the follicle and wasn't absorbed properly. And you should note that this is a study on women, applied to their upper abdomen for hirsutism.
All of this is aside from the fact that other studies support the idea that dht is a paracrine hormone.