- Reaction score
- 36
Melatonin + caffeine combo makes sense
Melatonin reduces cox2 expression while caffeine reduces cox2 protein. So it's very complementary.
Even if that's the case, I wouldn't do it.
To get anything out of these 2, you'll need to use larger doses.
If you use 15-20mg of melatonin per application, a certain percentage of it will undoubtedly leak into the serum.
The same goes for caffeine.
And you don't want both melatonin and caffeine circulating in your serum at the same time.
Hence why I wrote 'it doesn't make sense'. As in - it doesn't make sense to have them in the same solution.
The mixed signals you'll be giving your body aren't outweighed by the possible minor synergism between the two.
If you're keen on using both, add the caffeine to your morning topical and the melatonin to the evening one.