Why is IGF-1 and IGFB-3 important in Diabetes Mellitus and Androgenetic Alopecia? Well, a number of reasons; firstly, steroid hormones are affected enormously just based on the types of foods we eat. Even processed dairy increases circulating IGF-1. Secondly, another element is refined vegetable oils, which increase levels of the enzyme 5-alpha reductase. Third, there is another, that being environmental estrogens, also known as xenoestrogens. One example of a xenoestrogen is Bisphenol-A, which is found in the plastic of water bottles. Just ten micrograms of this substance can induce diabetes in small animals. So, you can see there is an estrogen component here. Additionally, trans-fats and many types of vegetable oils increase levels of estrogen.