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The Big Bad Awesome Brotzu Lotion Faq

Discussion in 'New Research, Studies, and Technologies' started by That Guy, Aug 7, 2016.

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  1. hilbert

    hilbert Established Member

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    further info from Brotzu in the Q&A session here:
    • Q: how aged can the alopecia be for the treatment to be effective?
      • A: "until the follicles are still active somehow, there could be an effect. The more recent, the better. We also made experiments with 20-30 yrs old AGAs and some follicles revived." [of course, and much clearer than the 5 yrs statement imho]
    • Q: for how long is the treatment effective?
      • A: "we don't have enough data yet; I can say that the first AA child treated (5 yrs ago) stopped the treatment 3 yrs ago, and still holds well. I can't say anything more than this so far. We're still going ahead with our own experiments."
    • Q: when will this be commercialized?
      • A: "I have no full visibility on this, and I can't and don't want to mention the pharma company working on this. However, I expect that it will be marketed during the next year."
    • Q: any sides?
      • A: "DGLA is in corn oil; carnitine is normally in lipid metabolism. So no, I'm not expecting any sides from these" [note that he does not mention s-equol, since it's not in his experimental compound]
     
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  2. yellowbluegrey

    yellowbluegrey Established Member My Regimen

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    Nice work man, that's some great info. So I guess the five year statement was more geared to other types of Alopecia, but it does cause regrowth to some extent on Androgenetic Alopecia patients. Psyched.
     
  3. JohnMclane

    JohnMclane New Member My Regimen

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    Thanks for making this thread, the other one turned into a mess
     
  4. That Guy

    That Guy Senior Member My Regimen

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    Okay, holy crap this is a lot of info and thank you for the translations. On the weekend, I'll set aside some time to compile this info into a .PDF because it's quickly growing too big for the OP.
     
  5. tzt

    tzt Experienced Member My Regimen

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    another question that i want to ask and i don't think if we've discussed this before for the Brotzu lotion.

    if we suppose all the Dr. brotzu's claims are true and the lotion is effective . do you think it can heal the oily seborrheic scalps.

    in my case i have diffused Androgenetic Alopecia + seborrheic only in the top of my scalps where the hair loss occur. and the side are OK.

    do you think it will remove the excess of sebum ??
     
    #45 tzt, Aug 10, 2016
    Last edited: Aug 10, 2016
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  6. Armando Jose

    Armando Jose Senior Member My Regimen

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    Good question.

    BTW good appreciation
     
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  7. hilbert

    hilbert Established Member

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    from what I've seen about Brotzu's attitude in that speech, his answer would likely be: "no idea"; so no point asking.
    I guess the bold statements attributed to him were carved out by the various interviewers.

    His presentation is miles aways from a marketing speech:
    - sometimes he's hesitant in explaining the slides (very likely, the slides were prepared by one of his collaborators, more deeply involved with this work)
    - he's showing the kind of knowledge-on-details typical of a supervisor
    - he seems quite honest, and repeated multiple times "I don't know, I have no idea, I can only report what we observed". (about hair facts)
     
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  8. hilbert

    hilbert Established Member

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    just to make it clearer: when I've mentioned "20-30 yrs old AGAs", it means people developing Androgenetic Alopecia for 20-30 yrs, i.e. slick bald heads.
    Nevertheless, they observed that some terminal hair shafts appeared in the desert. Few, but at least > 0.

    Concerning the 5 yrs thing, he didn't mention that here. He just said: as I'm learning from the alopecia experts here, a follicle needs to be still somehow alive to react to medications; the same applies to PGE1/DGLA + carnitine.

    Later on, another doctor reminded that follicles in AA never actually die, while in Androgenetic Alopecia they do; so there is no (known) time limit in treating an AA patient, while there is an (individual) expiration date in Androgenetic Alopecia patients. Brotzu was nodding.
     
  9. Giiizmo

    Giiizmo Established Member

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    Going a bit on a tangent here but this has been repeatedly disproved by some posts on this forum showcasing case studies where hair grew back on slick bald heads from specific trauma (e.g. burn) or aggressive drug regimens. The follicles in (nonscarring) AA are being actively suppressed by the immune system when they're otherwise healthy while Androgenetic Alopecia makes the follicles go dormant, which explains why it's so hard to get regrowth in Androgenetic Alopecia when too many years have gone by.

    Goes to show just how much some "specialists" know about hair loss.
     
  10. Youngerman

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    First off I want to thank @That Guy for creating this thread. You the man.

    Second @hilbert s translations are amazing. We will need you for this forum and its unbeilable we have not translated that video until yesterday.

    Lastly I have one quick question. I consider myself very familiar with the lotion and have done a lot of research on it but what do you think would be the effect on a younger guy (under 25) who has a more rapid pace of hair loss? Let's say a guy has been balding since 18 and is now 21 or 22 with a Norwood 2-3 diffuse. Could he return to his original state at 18 years? It would seem possible considering hair has only been lost for a year or two right? Just trying to gauge some info for the younger guys on this forum because the lotion seems to have its largest impact on those individuals.

    Thanks guys and keep up the good work
     
  11. Xaser94

    Xaser94 Established Member

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    I am personally in this situation Id say. Have been balding since maybe 17-18, now 22 with temple recession getting worse. Possibly heading to NW3 territory. I notice in the mirror the hairs in my temple are are minituirzed but not completely dead. So according to Brotzu, he seems to say as long as the follicle is still there then there is no reason it shouldnt grow back. But obviously nothing is certain until we try it on our own scalps.
     
  12. hilbert

    hilbert Established Member

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    what do you mean? This is exactly what they said at that workshop: follicles are never lost in AA, while they are in Androgenetic Alopecia.
    and it doesn't take to be a specialist to know about this.
     
  13. hilbert

    hilbert Established Member

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    exactly. I'd like to stress the impression I've got:
    - Brotzu is not speaking about the s-equol pathway: it's not part of his research compound; it's been added by Fidia imho
    - he's an expert of the theory behind PGE1/DGLA mechanism of action...
    - ...but he cannot (and does not want to) extrapolate anything based on such a small statistics (the groups of AA and Androgenetic Alopecia patients his team treated)
    - so, questions like "this is my status and pattern, what can I expect from DGLA + L-carnitine?" is both an incomplete question (since Fidia's lotion is going to include s-equol as well), and a question doomed to be left unanswered by the Doctor.

    (He has repeated several times: "my name is Nanni Brotzu, it's not God" :))

    I guess the current tests by Fidia are meant to shed a better light exactly on these points: develop wider statistics, which also take into account the 3rd active compound (s-equol).
     
    #53 hilbert, Aug 10, 2016
    Last edited: Aug 10, 2016
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  14. Blackber

    Blackber Experienced Member

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    Thanks again for doing this hilbet, we all appreciate it.

    Everything I've read about Brozu and his lotion confirm your thoughts regarding him being an expert in PGE1/DGLA - it seems he's used this ingredient in more than one application over the years and understands it well.
     
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  15. Torin

    Torin Established Member

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    Thank you for the translation.

    The video translation is interesting. Dr. Brotzu doesn't seem as confident about it as he sounded in the Bella capelli and other interviews.

    At least he seems honest and hopefully it will work to some extent. The 5 years regrowth thing always seemed like a bit of a stretch.

    In the frames that showed the bald scalp growing back hair follicles, does he say on which patient this was? I'm guessing it was the child with AA?
     
    #55 Torin, Aug 10, 2016
    Last edited: Aug 10, 2016
  16. hilbert

    hilbert Established Member

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    yes those were aa.
     
  17. rlf

    rlf Established Member

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    This is actually amazing! If they get regrow in slick bald heads that have been balding for 30 years it must work even better on people that have still lots of hair.
     
  18. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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  19. Grasshüpfer

    Grasshüpfer Experienced Member My Regimen

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    @hilbert Somebody get this man a medal.

    I actually assumed with 5 years he was talking about a guy loosing hair at a glacial pace, so the usual 10% regrowth.
    If it really revives very small numbers of +10 year old follicles, the five year claim might really mean something. (Even though 'course probably not complete rewind for guys who went from 0 to nw7 in two years.)
     
  20. hilbert

    hilbert Established Member

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    chill down.. he said some few hair. (in some months)
     

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