Companies do that when they are about to launch clinical trials and their pre-clinical data is 100% complete. It definitely means means something in the sense that they are preparing for human trials in the short term.
Stemson is going to use minipigs in the next stage of their hair cloning research
- Thread starter werefckd
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Even better then!
I don't see where you guys pulled the info from, but if they are preparing right now to submit an IND it means we'll see see human trials in H2 2021 or H1 H2022. If they are just doing IND enabling work it means that they're still doing pre-clinical research.
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Does this mean we could get a timeline this year!?
I know that you're not god and dont know EVERYTHING, but you seem to know pretty much about all this regulation topic haha
I'm sure they'll give forward guidance on when they expect to start human trials when they announce the closure of their next round of funding. In the Fortunis investors video the CEO said it would be announced this spring. That funding would be for initial human trials.Does this mean we could get a timeline this year!?
I know that you're not god and dont know EVERYTHING, but you seem to know pretty much about all this regulation topic haha
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Attachments
I don't recall them talking about taking skin samples except to test on. Their technology uses blood samples.
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Autologous Induced Pluripotent Stem Cell-Based Cell Therapies: Promise, Progress, and Challenges - PubMed
The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as a starting material for autologous, or patient-specific, stem cell-based therapies. Since the first publications describing the generation of iPSCs from human tissue in 2007, a Phase I/IIa clinical...
pubmed.ncbi.nlm.nih.gov
One of many Stemson Therapeutics' scientists is listed as an author on this article of pubmed.
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Another question, you guys might not be able to answer, but it would be cool to discuss it...
I saw an interview again and Alexey or well Hamilton said that they customize the hair to the need of the patient!? Does this mean Androgenetic Alopecia is treaten differently than... AA?
Does this mean they try to make the follicle permanent and not susceptible to Androgenetic Alopecia!? This would match then with the Fortunis guy, making claims that it will give a natural density/hairline, that the hair will stay permanently and won't bald ever. Someone remember that phrase and can elaborate it!?
I saw an interview again and Alexey or well Hamilton said that they customize the hair to the need of the patient!? Does this mean Androgenetic Alopecia is treaten differently than... AA?
Does this mean they try to make the follicle permanent and not susceptible to Androgenetic Alopecia!? This would match then with the Fortunis guy, making claims that it will give a natural density/hairline, that the hair will stay permanently and won't bald ever. Someone remember that phrase and can elaborate it!?
I'm pretty sure they'll try to make hairs immune to AA regardless of the patient, if it's possible. By customization I think they were referring to thickness, texture, color, etc.
I don't think it's possible for them to make hair "immune" to AA. Even our donor hair is not immune to AA, so I don't really know how they would program the genetic predisposition of the follicle to be any different then if you were to move a follicle from the donor to the Norwood area.
Best we could hope for is that the hair is "resistant", meaning maybe it thins over time like someone who wasn't predisposed to AA would experience anyways. If this were to work though, would it even matter? Eventually it would be available everywhere with reduced prices and you could just go top up your hair as you needed.
99% of people are already immune to AA, that's an autoimmune disease that happens when the follicle loses its immunoprivileged status. A.G.A. is caused by the androgen receptor shutting down Wnt signaling. There aren't many androgen receptors in the donor area in people with DPA, which is a form of A.G.A., but some 10% of A.G.A. sufferers have DUPA, meaning their hair thins even in the donor region. Everyone has age-related thinning in all areas, even Native Americans who are not susceptible to A.G.A., but that is a completely different thing and only leads to poor quality hair, not baldness. If you remove the androgen receptor, or clone hairs that do not have it, then you get follicles that are immune to A.G.A.
Right, we meant Androgenetic Alopecia. How does one remove the androgen receptor? Even in people without Androgenetic Alopecia, their follicles still have the receptors.
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It is unlikely that the horseshoe pattern thins out dramatically. If they are able to create the same follicles as the ones from the back area, they would work as a "new" follicle, means starts as a completely new one + aren't susceptible to androgens.
I wonder if this approach can give non Androgenetic Alopecia grandpas and grandmas full density back, as they have age-related thinning. Lol
Occipital follicles don't have enough receptors to reach the threshold for triggering a shutdown of Wnt signaling. That's why hair transplants last forever in 90% of people. It's only the unlucky few with DUPA that are screwed.
So based on this, hair follicles are inherently immune to miniaturization but miniaturized because of androgen receptors? Do you predict Stemson's cloned hair would have sufficient androgen receptors to be susceptible to miniaturization?
That's what I was referring to in less specific terminology in my previous post. My question of how they would "choose" what type of follicle they create still stands though, because they said this process is done from a blood sample, not occipital follicle extraction.
I'm not familiar enough with their process to say. Could be.