Setipiprant Does Work, But Only On Really Really High Doses. | Page 15 | HairLossTalk Forums

Setipiprant Does Work, But Only On Really Really High Doses.

Discussion in 'New Research, Studies, and Technologies' started by westonci, May 8, 2017.

  1. icecold7

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    @Sanchez1234 -> Great work. This helps to alleviate a key outstanding question on this thread about Kane's seti.

    However, I still feel like there are two related outstanding questions:

    1) Is the salted version of seti just as effective as the acid version (base version)?
    2) Does the salted version of seti have other sides, or is it potentially harmful to consume orally? (which I'm doing right now at 1g/day)

    So regarding these questions: does anyone know enough about pharmacology to speak intelligently about either of these, particularly #1? Should the two molecules behave in a similar fashion to attack the PGD2 receptor? Or is it possible they would behave very different? Is there a reason the salted version of seti would be inappropriate to take orally? (For instance, @westonci made a comment to this effect in post #257 on this thread, which has be a bit nervous).

    On a related note: Has anyone tried Kane's seti orally and gotten positive results? westonci's results seem to be with the acid version. I would prefer to take that version (instead of Kane's like I'm doing currently) to minimize variables here, so if anyone can let me know where the private forum group buy procured their seti, that would be awesome.
     
  2. Sanchez1234

    Sanchez1234 Established Member

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    Well, i don't know. I cant tolerate the salted seti from Kane orally.

    I am on the private forum but the GB arent that frequent. I ordered oral acid seti from the same guy i ordered darolutamide from. The darolutamide was tested legit, so i am going to try the acid form of seti. Kanes seti is salted and more suitable for topicals.

    Could be no difference at all between the working mechanism of salted and acid seti, but i will find out soon enough...
     
  3. icecold7

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    I've been on 1g/day taken orally of Kane's seti now for 2-3 weeks. The good news is that I'm getting minimal to no sides (potentially drier eyes, but totally livable). My issue is that so far it's done nothing that I can tell to stop my hair loss, and I've actually noticed increased itch on my scalp and a scary amount of shedding (I used to get 5-10 hairs in the shower per day and now I'm at 20-30. It's a lot of hair).

    I'm fully aware that existing mainstream treatments like Propecia and Minoxidil can cause shedding at the beginning of treatment. (https://www.hairlosstalk.com/news/education/understanding-shedding-hair-loss-treatment/) However, looking @westonci 's experience on this thread and other experiences with seti, I haven't heard any stories of shedding related to seti. In fact, the stories on this thread and others seem to indicate that there are almost-immediate positive effects on hair loss, not an increased shedding period...

    I know I'm only a few weeks in, but this result has me wondering if the salted version of seti is just not effective? (I'm on Kane's stuff)

    If others that have had success with seti also had shedding the first few weeks, let me know as that will help guide my decision of whether to continue with this regimen.

    If I don't get positive reports from others about Kane's stuff, my next move is to start exploring how to get the acid version of seti.
     
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  4. Sanchez1234

    Sanchez1234 Established Member

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    "So how was janoshik able to verify it being the same?"

    13C NMR doesn't differentiate between salt and base, that's why it was chosen as an alternative method.

    "1) Is the salted version of seti just as effective as the acid version (base version)?"

    Little less effective per unit of weight, but it's of no real impact.

    "2) Does the salted version of seti have other sides, or is it potentially harmful to consume orally? (which I'm doing right now at 1g/day)"

    No. Ingested setipiprant would eventually become salt as well, imo.


    With best regards,
    Janoshik
     
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  5. inmyhead

    inmyhead Established Member

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    That Janoshik site seems very fishy to me. Is monty = Kane btw? He just posts his quotes out of nowhere.
     
  6. Sanchez1234

    Sanchez1234 Established Member

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    I have no idea if monty =kane.

    And why does Janoshik site seems fishy? The guy who owns it is really helpfull. He lives on Slovakia. The only way to know if the tester is for real is to send it to two testers. I trust Janoshik.
     
  7. inmyhead

    inmyhead Established Member

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    Where did you find Janoshik? Was it reccomended by monty?
     
  8. Pigeon

    Pigeon Established Member My Regimen

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    Don't worry, I had an initial shed on seti in the beginning as well. After month and half it stopped.
     
  9. Sanchez1234

    Sanchez1234 Established Member

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    From the dutch forum. Not by someone named monty. Janoshik seems to well known on the bodybuilding forum. At least thats what i read
     
  10. Sanchez1234

    Sanchez1234 Established Member

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    How much do you take daily?
     
  11. CuckedByChad

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    Would add this to my regimen if it wasn't so goddamn expensive, fml.
     
  12. Pigeon

    Pigeon Established Member My Regimen

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    100mg morning and evening.
     
  13. ZenHead

    ZenHead Established Member My Regimen

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    So, kane's seti is legit? I'm about to order 100g of it, and take 500mg every 12 hours. Just need to know if it's the real deal, since apparently he only sells the salt version which is less effective from my understanding.
     
  14. Jonnyyy

    Jonnyyy Experienced Member My Regimen

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    Dang 100g how much is that?
    Edit: Holy shit $900 that's $270 a month $3000 a year........
     
  15. ZenHead

    ZenHead Established Member My Regimen

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    Yeah... ridiculous I know but I'm running out of options. And hair. Hopefully I can just maintain with seti until fevi / brotzu / shiseido comes out. Seti seems to be great for maintenance.
     
  16. icecold7

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    I'm in the same boat and thinking about it the same way. The cost is insane, but if I can maintain for just a couple of years it feels like these other alternative options will be released which should be less expensive when they are eventually commercialized.
     
  17. icecold7

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    That makes me feel a bit better (although 6 weeks of this and not sure I'll have any hair left!!)

    @Pigeon , do you feel the seti has now stabilized your hair?

    Anyone else get initial shedding with Seti?
     
  18. Pigeon

    Pigeon Established Member My Regimen

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    Yeah, it's weird though. On the top, the classical part you're balding, my hairloss halted completely. But, on the (lower) sides of my head, the parts that are "immune" against hairloss, I now experience hairloss. Weird, but maybe it will stabilize there too...

    Anyway rather be bald on my sides than top.

    Seti is definitely worth it to try for atleast 6 months and after that period you can make your conclusions. I recommend it. Also can't wait for the official studies to come out next year, then everyone will know if it works or not.
     
  19. ZenHead

    ZenHead Established Member My Regimen

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    I’ve been in contact with Kane about getting the acid form of seti which is better than the salt form for taking orally. He said he only sells the salt due to it being more soluble in ethanol for topical application. Is anyone else interested in the acid form for the oral route? I’m going to ask if he could possibly start making the acid form but I doubt he would do it unless we have more people interested in it.
     
  20. icecold7

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    HA! I just asked him the same exact thing earlier today. If anyone else is interested in the acid version, ask Kane and hopefully he'll procure it.

    On a related note, another member of this forum has a supplier in China and he gave me their contact info. This member said that he tested a product from this supplier (but not the seti) and it tested legit. Given that it's from China (and not Kane), I'm still not comfortable taking it without testing it first. So my plan is to order some from this person, get it tested, and then try it if it tests legit.

    Today I asked the supplier about 1) shipping details, 2) acid vs. salt, and 3) purity. This is his response.

    upload_2017-11-27_18-9-27.png
     

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