Before I begin explaining why Setipiprant does work, let me give you some reference. On the private forum Setipiprant cost about $340/25g Allergans Clinical trials is doing 2g daily At that dose $340 would only last you 12 days, lol Practically everyone on Seti is doing between 50 - 250mg daily which is practically nothing and explains the mediocre results some are getting. Having experimented with the prostaglandin protocol and upping and lowering doses of both PGE2 and seti i can confirm that the Seti dose plays a much larger role in the final results I had a convo with someone on the private forum who is doing 1.25g Seti every day and he claims hes getting really nice results I saw some of his before and after pics and they are very impressive, even better than mine. Unfortunately Im not that rich so Im stuck with doing around 500mg (only this past month was doing 250mg before that) every day and Im still getting decent thickening for the thinning hairs and not so much in the slick bald areas. I started out doing 250mg seti when I began a year ago and moved up to 500mg for the last month or so Unfortunately the newest version of seti from the private forum doesnt dissolve in ethanol/polsorbate/dmi solution, so im forced to go all oral in about 2 months when I run out of my current supply. Im absolutely convinced that anything under 1g is largely a waste, which is why so many guys claim seti doesnt work etc. I notcied a significant difference in results when moving from 250mg to 500mg daily. We currently have a GB on the private forum for seti going on right now and Im trying to get 6 months supply of 1.25g seti daily which is about 225g and would run me about $3060 which is not fucking cheap. TLDR; Seti under 1g per day is largely a waste. Seti does work but you need to go big or go home. Im planning on doing 1g orally for 6 months.