- Reaction score
- 614
Ah yes the tumble begins
(Not defending this joke) but the fact they’re still in the same order/the same compounds remain tells me it’s probably just a poor formatting job tbh. Not something you’d expect from such a legit companyGood catch!View attachment 158254
Any time from now really, the 1 year data had been collected in Jan so at least a summary of results for the sake of marketing should be due in the next couple of months if they want to keep stakeholders happy.Was the plan for them to release the results in March? Can't recall.
I wonder if they still claim to be valued at $12 billion
You know this doesn't mean much at all, right? One of the 4 drugs removed is the same as the first one, which is currently in phase 3.Ah yes the tumble begins
I know their valuation never meant much at all yes because they pulled the numbers out of nowhereYou know this doesn't mean much at all, right? One of the 4 drugs removed is the same as the first one, which is currently in phase 3.
Otherwise, it's really not uncommon for a pre-commercialization biotech companies to focus on lead candidates. It's actually what happens with basically every one of them.
Could this potentially be the reason why 0.15% outperformed 0.25% because the 0.25% SM04554 / Dalosirvat dose was inhibiting too much TNF-a?Lol TNF-a is required for hair growth though. Just don't want too much of it.
But if you say that you have "solved" all these diseases, then that is very dubious. It's a shame that the good companies like Tissuse get little investment while people swinging the big speeches are given billions
I think he's been on record saying he believes the WNT pathway has the potential to cure many diseases and that their science will work towards this.Where does he say he "solved" all these diseases? The CEO showed some promising therapies and really believed in what he's doing, I have neve heard him say he "cured" or "solved" anything.
Tissuse, Tsuji and Follica are the ones who should take notes form Samumed's approach if they want to be taken serious in the market and get real money to fund their research.
How do you know he "really" believes in what he's doing? Have you given him a polygraph?Where does he say he "solved" all these diseases? The CEO showed some promising therapies and really believed in what he's doing, I have neve heard him say he "cured" or "solved" anything.
Tissuse, Tsuji and Follica are the ones who should take notes form Samumed's approach if they want to be taken serious in the market and get real money to fund their research.
I think you mean it does have an effect, because we already have data that shows it does in a measurable capacity. The question is more how long the benefits last and to what extent they cap out at.Come on people it's a SIRT agonist, as is their osteoarthritis medication. It seems to me they're just putting everything into this one pathway and embellishing the sh*t out of its effectiveness for marketing purposes. Will it have an effect? Probably. But can we please not hype this to be anything more than a drop in the bucket
Min is a drop in the bucket tooI think you mean it does have an effect, because we already have data that shows it does in a measurable capacity. The question is more how long the benefits last and to what extent they cap out at.
Sorry that some of us that got 0 benefit from min are hoping we'll have another pathway to go down where currently none exist. That's not a drop in the bucket to many people. If you have something else that people can use that a relatively safe/easily sourced alternative to min lets hear it.
Yeah and a lot of people get nothing from that. So what's not a drop in the bucket>Min is a drop in the bucket too
Yeah and a lot of people get nothing from that. So what's not a drop in the bucket>
The median change in total hair count from the baseline was 23/cm2 (range, 17 to 39) in the VPA group and 1/cm2 (range, 68 to 70) in the placebo group
Would there be any side effects associated with using VPA?Based on their unimpressive results there are Wnt agonists already on the market that will meet or exceed SM's potential. Instead of waiting for SM just use VPA, it's probably more potent.
Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis - PubMed
Valproic acid (VPA), a widely used anticonvulsant, inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway, which is associated with hair growth cycle and anagen induction. To assess the efficacy of topical VPA for treating androgenetic alopecia (Androgenetic Alopecia), we performed a...pubmed.ncbi.nlm.nih.gov
If you aren't a responder to minoxidil you can take oral minoxidil, which has a 100% response rate, or get minoxidil sulfate powder and mix it yourself, also 100% response rate. Microneedling and tretinoin also turn minoxidil non-responders into responders. Or you can go the PGF2a route, latanoprost and bimatoprost are already on the market and equivalent to minoxidil. SM will not perform as well as minoxidil so it's pretty much useless. If you get side effects from minoxidil or pgf2a analogues then just use VPA instead of waiting for SM. There's no drug more advanced than minoxidil coming in the next 5 years, but you can get KY19382 on the grey market which might exceed minoxidil.
Just how mild is your balding lol I swear I used to be like you until it got worse, now I need better results on the horizon to keep me happyEnough speculation and broscience.
I'll wait for the the results and if they're in line with their phase 2 results, I'll be very happy.
He wasn't rich before Samumed. His entire net worth according to Forbes is the valuation of his shares of Samumed.Of course nobody knows but he seems genuine from what I have seen imo (or just a good actor). Also why would he do something like this if he didn't believe in it? He was already rich before Samumed. He also puts his reputation on the line.