Samumed Sm04554 Results Normalized To Baseline

[pegasus2]

Sure, because we totally know how to use it, how much of it, if it's daily, weekly or wtf AND it's totally legit from a Chinese lab, because they got the rights to it, why not just skip Phase 3 and get FDA approval from the lab?

The dosage Samumed uses is .15% once a day, and people have had the compound tested to verify it. It's a dud.

 

[trialAcc]

The dosage Samumed uses is .15% once a day, and people have had the compound tested to verify it. It's a dud.

Thankfully we know it's a dud because 8 dudes on a forum told us so.

 

[pegasus2]

Thankfully we know it's a dud because 8 dudes on a forum told us so.

Fair enough, just don't pretend nobody has used it right.

 

[trialAcc]

Fair enough, just don't pretend nobody has used it right.

I never did, I actually do value the accounts of them none-the-less but I just don't think it replaces the study data in any way. If the data came out and said the mean hair count increase over the study period was +20%, would your opinion change? Or is that still a dud to you because of these accounts?

 

[pegasus2]

I never did, I actually do value the accounts of them none-the-less but I just don't think it replaces the study data in any way. If the data came out and said the mean hair count increase over the study period was +20%, would your opinion change? Or is that still a dud to you because of these accounts?

I'd be more impressed if the study showed +20% on norwood 3s instead of full baldites. +20% on a scalp with only 1 hair to begin with means that 1 out of 5 subjects regrew a single hair. Maybe that hair just happened to come out of resting phase anyway at that time.

 

[trialAcc]

I'd be more impressed if the study showed +20% on norwood 3s instead of full baldites. +20% on a scalp with only 1 hair to begin with means that 1 out of 5 subjects regrew a single hair. Maybe that hair just happened to come out of resting phase anyway at that time.

What? Literally none of these studies start on an area with 0 hairs, and if they do, it's a very small percentage of the overall testing pool. The hair count is always displayed per cm2 and the mean is usually is in the 80s-100s to encapsulate a slightly thinning area.

The phase 2 studies were conducted on a 1 cm2 area with a mean hair count of 100~ hairs, meaning not a single one (based on the #s) was bald in that area and the mean results were 10% after three months.

 

[Throwaway94]

Have we confirmed the actual mechanism of SM yet? Can't find anything credible but it looks like the structure was originally also called dalosirvat, and it modulates the wnt pathway by activating SIRT.

It has a few downstream effects that are in theory good for hair but I just don't see this being very reliable.

 

[nick123]

Apparently SM04554s friendlier drug name is named: Dalosirvat

Source:

Dalosirvat - Samumed - AdisInsight

Dalosirvat (formerly SM 04554) is a small-molecule compound that may activate the WNT pathway, being developed by Samumed for the topical treatment of

adisinsight.springer.com

If anyone's interested in buying the drug profile and pasting it here so we can learn more about Dalosirvat/SM04554 mechanism of action that'd be great!

Edit: I would buy the drug profile myself, but I am currently super broke.

 

[Tom4362]

Apparently SM04554s friendlier drug name is named: Dalosirvat

Source:

Dalosirvat - Samumed - AdisInsight

Dalosirvat (formerly SM 04554) is a small-molecule compound that may activate the WNT pathway, being developed by Samumed for the topical treatment of

adisinsight.springer.com

If anyone's interested in buying the drug profile and pasting it here so we can learn more that'd be great!

Why don't you? ;-)

 

[Gegen]

As it has been said, it's a SIRT activator : https://www.hmobio.com/products/Dalosirvat.html

EDIT: Also, SIRT proteins inhibit TNF-a activity, which is good for hair independently of Wnt activation. (See the thread about Substance P).

SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1 - PubMed

Sirtuin 1 (SIRT1), a NAD(+)-dependent class III histone deacetylase, participates in regulating cellular apoptosis, senescence and metabolism by deacetylating histones and multiple transcription factors. In this study, we aimed to determine the effect of SIRT1 on the apoptosis of vascular...

pubmed.ncbi.nlm.nih.gov

SIRT6 inhibits TNF-α-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway - PubMed

SIRT6, with both deacetylase and ADP-ribosyltransferase activities, is predominantly expressed in the nucleus. It has been revealed that SIRT6 regulates various biological functions including metabolism, aging and stress resistance. This study aims to investigate the role of SIRT6 in vascular...

pubmed.ncbi.nlm.nih.gov

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

Inflammation is one of main mechanisms of autoimmune disorders and a common feature of most diseases. Appropriate suppression of inflammation is a key resolution to treat the diseases. Sirtuin1 (Sirt1) has been shown to play a role in regulation of inflammation. Resveratrol, a potent Sirt1...

journals.plos.org

 

[inmyhead]

Why are you guys so impatient? Just wait a few months or so.

 

[Gegen]

Why are you guys so impatient? Just wait a few months or so.

I'm not particularly impatient lol, I just find that knowing the MoA is interesting from theoretical view.

 

[MrV88]

Apparently SM04554s friendlier drug name is named: Dalosirvat

Source:

Dalosirvat - Samumed - AdisInsight

Dalosirvat (formerly SM 04554) is a small-molecule compound that may activate the WNT pathway, being developed by Samumed for the topical treatment of

adisinsight.springer.com

If anyone's interested in buying the drug profile and pasting it here so we can learn more about Dalosirvat/SM04554 mechanism of action that'd be great!

Edit: I would buy the drug profile myself, but I am currently super broke.

Hopefully we will see some progress, at least it got a Name, so probably a release candidate in some weeks to years

 

[Will Be an Egg in 5 years]

Why are you guys so impatient? Just wait a few months or so.

I can wait, but my folicles don't

 

[John Difool]

Very interesting.

Seems TNF is one of the causes of inflammation in our bodies. (but this doesn't mean TNF is bad per se)

What Is Tumor Necrosis Factor (TNF)?

TNF(tumor necrosis factor): Tumor necrosis factor is a substance in your body that causes inflammation. Learn about the role it plays in diseases like rheumatoid arthritis (RA).

www.webmd.com

It doesn't mean being bald is bad per se too

 

[pegasus2]

Lol TNF-a is required for hair growth though. Just don't want too much of it.

 

[Gegen]

What's going on with samumed's pipeline ? https://www.samumed.com/pipeline/default.aspx

 

[FilthyFrancis]

What's going on with samumed's pipeline ? https://www.samumed.com/pipeline/default.aspx

What's wrong?

 

[trialAcc]

What's wrong?

They removed about half the drugs, it seems. It had 8+ last time I was on there, which was probably months ago.

 

[Numerous_Bet_3027]

They removed about half the drugs, it seems. It had 8+ last time I was on there, which was probably months ago.

Good catch!