Samumed Sm04554 Results Normalized To Baseline

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trialAcc

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pegasus2 said:
I'd be more impressed if the study showed +20% on norwood 3s instead of full baldites. +20% on a scalp with only 1 hair to begin with means that 1 out of 5 subjects regrew a single hair. Maybe that hair just happened to come out of resting phase anyway at that time.
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What? Literally none of these studies start on an area with 0 hairs, and if they do, it's a very small percentage of the overall testing pool. The hair count is always displayed per cm2 and the mean is usually is in the 80s-100s to encapsulate a slightly thinning area.

The phase 2 studies were conducted on a 1 cm2 area with a mean hair count of 100~ hairs, meaning not a single one (based on the #s) was bald in that area and the mean results were 10% after three months.
 
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Throwaway94

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Have we confirmed the actual mechanism of SM yet? Can't find anything credible but it looks like the structure was originally also called dalosirvat, and it modulates the wnt pathway by activating SIRT.

It has a few downstream effects that are in theory good for hair but I just don't see this being very reliable.
 
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nick123

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Apparently SM04554s friendlier drug name is named: Dalosirvat

Source:

Dalosirvat - Samumed - AdisInsight

Dalosirvat (formerly SM 04554) is a small-molecule compound that may activate the WNT pathway, being developed by Samumed for the topical treatment of
adisinsight.springer.com adisinsight.springer.com

If anyone's interested in buying the drug profile and pasting it here so we can learn more about Dalosirvat/SM04554 mechanism of action that'd be great!

Edit: I would buy the drug profile myself, but I am currently super broke.
 
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Tom4362

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nick123 said:
Apparently SM04554s friendlier drug name is named: Dalosirvat

Source:

Dalosirvat - Samumed - AdisInsight

Dalosirvat (formerly SM 04554) is a small-molecule compound that may activate the WNT pathway, being developed by Samumed for the topical treatment of
adisinsight.springer.com adisinsight.springer.com

If anyone's interested in buying the drug profile and pasting it here so we can learn more that'd be great!
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Why don't you? ;-)
 
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Gegen

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As it has been said, it's a SIRT activator : https://www.hmobio.com/products/Dalosirvat.html

EDIT: Also, SIRT proteins inhibit TNF-a activity, which is good for hair independently of Wnt activation. (See the thread about Substance P).
pubmed.ncbi.nlm.nih.gov

SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1 - PubMed

Sirtuin 1 (SIRT1), a NAD(+)-dependent class III histone deacetylase, participates in regulating cellular apoptosis, senescence and metabolism by deacetylating histones and multiple transcription factors. In this study, we aimed to determine the effect of SIRT1 on the apoptosis of vascular...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov

SIRT6 inhibits TNF-α-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway - PubMed

SIRT6, with both deacetylase and ADP-ribosyltransferase activities, is predominantly expressed in the nucleus. It has been revealed that SIRT6 regulates various biological functions including metabolism, aging and stress resistance. This study aims to investigate the role of SIRT6 in vascular...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
journals.plos.org

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

Inflammation is one of main mechanisms of autoimmune disorders and a common feature of most diseases. Appropriate suppression of inflammation is a key resolution to treat the diseases. Sirtuin1 (Sirt1) has been shown to play a role in regulation of inflammation. Resveratrol, a potent Sirt1...
journals.plos.org journals.plos.org
 
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MrV88

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nick123 said:
Apparently SM04554s friendlier drug name is named: Dalosirvat

Source:

Dalosirvat - Samumed - AdisInsight

Dalosirvat (formerly SM 04554) is a small-molecule compound that may activate the WNT pathway, being developed by Samumed for the topical treatment of
adisinsight.springer.com adisinsight.springer.com

If anyone's interested in buying the drug profile and pasting it here so we can learn more about Dalosirvat/SM04554 mechanism of action that'd be great!

Edit: I would buy the drug profile myself, but I am currently super broke.
Click to expand...
Hopefully we will see some progress, at least it got a Name, so probably a release candidate in some weeks to years
 
John Difool

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Pigeon said:
Very interesting.

Seems TNF is one of the causes of inflammation in our bodies. (but this doesn't mean TNF is bad per se)

www.webmd.com

What Is Tumor Necrosis Factor (TNF)?

TNF(tumor necrosis factor): Tumor necrosis factor is a substance in your body that causes inflammation. Learn about the role it plays in diseases like rheumatoid arthritis (RA).
www.webmd.com www.webmd.com
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It doesn't mean being bald is bad per se too
 
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pegasus2

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Lol TNF-a is required for hair growth though. Just don't want too much of it.
 
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Numerous_Bet_3027

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trialAcc said:
They removed about half the drugs, it seems. It had 8+ last time I was on there, which was probably months ago.
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Good catch!
Samumed.png
 
waynakyo

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Was the plan for them to release the results in March? Can't recall.
 
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