Doesn't need to be; there is literally no doubt that they will do absolutely JAK sh*t for Androgenetic Alopecia
A guy took oral JAK, got his hair back from AA but had like a NW4 pattern.
Neal Walker's explanation for this was some BS about how "Topical JAK will better reach the follicle because oral drugs don't" or something along those lines.
Which, as Swoop has thoroughly explained here: Is horseshit.
There is no shortage of studies out there showing how oral drugs have no problem reaching as far as the outermost layers of the skin. Finasteride does it, oral minoxidil does, acne medications obviously do, and even JAK inhibitors do.
Case closed; if JAK inhibitors were going to work for Androgenetic Alopecia, we would have definitely seen it by now in male patients with Androgenetic Alopecia who were also treated for AA — JAK is a cope.
Lastly, I've repeatedly asked proponents of it to explain to me how, after fibrosis has set in and your little follicles have gone to hell, how JAK or other topicals are going to create new follicles to replace them and the best I've got is "durr, I'm not educating you!" in 3-paragraph-long rants when the answer to my question should take 3 sentences at most.
It's interesting you mentioned fibrosis.
You do know what fibrosis is the outcome of. Inflammation.
Do you know what inflammation results in except fibrosis?
Degeneration and structural distortion of the area affected.
Does it happen overnight?
Nope. It takes time. Is there a window? Maybe.
Is it propable that the AA patient who also had male pattern baldness was past that window?
Most probably.
Therefore, nobody can really know the effect of JAK inhibitors, let's say, on a 30-year-old man who is just realizing "Man, I'm losing my damn hair!".
Moreover, oral minoxidil can cause severe side-effects so, PLEASE, don't ever say that again. You don't want to mislead people, do you?
Last but not least, the local concentration of a substance is key. Topical application may be more effective than systemic one.
My advice, you better not act like the wise man. Neither me nor anybody else.