Replicel Is On Fire Lately — Data In Feb. | Page 109 | HairLossTalk Forums

Replicel Is On Fire Lately — Data In Feb.

Discussion in 'New Research, Studies, and Technologies' started by That Guy, Jan 24, 2017.

  1. br1

    br1 Senior Member

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    That, and the fact they invested a bunch of money, opened a new facility to research it (https://www.shiseidogroup.com/releimg/2289-e.pdf).. that plus the results from Phase 1.

    It seems very promising to me. But, let's keep our feet on the ground. Shiseido next milestone is to release Phase2 results. If they succeed, then that's it!

    After release, idk.. It will be open to foreigners (since they said it would be performed in hospitals, initially)?

    But, 1 step at a time.!
     
  2. br1

    br1 Senior Member

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    Shiseido's RCH-01 is an improved version of Replicel's tech.

    Confirm?

    * I remember reading that they (Shiseido) were improving the technology.. That's why they opened a research facility in Kobe.
     
  3. Hate da Bt

    Hate da Bt Established Member My Regimen

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    Nope, Aderans failed to amplify mesenchymal stem cells (=dermal papillae) and that is why it ended.
    On the other hand, Replicel succeeded in amplifying another strand of cells, the sheath cup ones, and that is why Shiseido bought RCH-01 for the Asian market.
    What's interesting is that Tsuji's trying to amplify those stem cells, Aderans failed to amplify, and, if he succeeds, those stem cells could be injected, as well.
    I'm pretty confident that the injection of epithelial and mesenchymal stem cells will be proven to be a rather effective treatment for halting hair loss (presumably even restoration!).
     
    #2163 Hate da Bt, Jan 11, 2018
    Last edited: Aug 8, 2018
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  4. Hate da Bt

    Hate da Bt Established Member My Regimen

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    Shiseido has readjusted doses and the number of injections per patient.
    I think there were three injections included in the trial, but I ain't 100% sure.
     
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  5. MrV88

    MrV88 Experienced Member My Regimen

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    Don't know if they've improved it, but I'm sure as hell they did. İmmunization is definitely done for at least 2 years, maybe even more so a combination of a good hair transplant and Shiseido should be seen as a close 70-80% cure.
    I really do hope that they've achieved thickening of minituarized and thinned hair (not totally gone ones), so a reverse of 1-2 Norwood could be possible with this.
    Still waiting for trial results and a clearance if it could grow back at least some hair, especially in the donor area.
     
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  6. d3nt3dsh0v3l

    d3nt3dsh0v3l Experienced Member My Regimen

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    Jesus Christ man.

    But then again, injected daily with tons of DHT is as much of a death sentence to baldites as it is a type of HRT and recreational steroid use.

    Basically you're right, it sounds like torture to have a mirror and watch your hair fall out, but hair loss, body hair growth, beard gains, acne and ass cancer will probably be compounded with strength gains, size and leaning out haha. Having a mirror around might not be torture if you are shredded brah.

    Hair loss and prostate cancer aside, I actually like DHT ;_; I think he is a pretty cool and badass guy.
     
    #2166 d3nt3dsh0v3l, Jan 11, 2018
    Last edited: Jan 11, 2018
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  7. TONSofBODYHAIR

    TONSofBODYHAIR Established Member My Regimen

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    I may not know the exact details about what strand of cells they multiplied or not but im 100% sure when i searched about the aderans trials they managed to halt all hairloss similar to Rch01 but they didnt manage regrowth, they had a viable hairloss treatment and they threw it away because it didnt produce any significant cosmetic result although itoffered sideless maintenance
     
    #2167 TONSofBODYHAIR, Jan 11, 2018
    Last edited: Jan 11, 2018
  8. Noisette

    Noisette Established Member

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  9. SkinDiesel

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    Anybody else optimistic that Shiseido + Follica could act as a functional cure for many?
     
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  10. d3nt3dsh0v3l

    d3nt3dsh0v3l Experienced Member My Regimen

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    We should be careful about which is which, because I think that the principle behind RCH-01 and Riken is pretty different.


    Go to 3:20 (since this site doesn't allow time stamped embedding).
    You see that what Ken has shown is that if you take dermal and epithelial cells and put them in a medium, they find each other and assemble into organoids and bear hair. The thinking then was, what if we injected both cells into the skin - wouldn't we expect the same?


    Go to 5:00

    What Replicel has shown is that if you only inject dermal sheath cup cells (which are thought to produce dermal papilla cells - the ones that actually make the hair), then they integrate themselves into existing dying follicles and rejuvenate them (they have also tried other cells but DSCs gave the best results so this is part of the "official" product). So no new follicles or massive density increase but maintenance.

    Perhaps what happened with Aderans is that self-assembly of hair was expected but instead a maintenance therapy was discovered. I am not too sure.

    What Tsuji is trying to do is create in lab the organ germ for a follicle, which is essentially a partially organized ball of epithelial and mesenchymal cells, and then to inject that germ into the scalp, where it should complete development and hopefully integrate very well with the scalp, for example connected to the arrector pili muscle, which in turn may direct the assembly of the follicle with the natural hair pattern alignment. The cool thing about Tsuji is that he has shown that this does indeed work as intended (in mice, even with using human cells). Now we wait for them to do it on humans :)
    upload_2018-1-11_16-38-3.png

    upload_2018-1-11_16-37-23.png
    As a side note, mesenchymal stem cells differentiate into several useful cell types, so solving this culturing problem is a big deal for Tsuji since he is interested in organ regeneration in general. His book Organ Regeneration is really cool stuff.


    Perhaps someone more knowledgeable can correct and/or append me if I have stated anything incorrectly.
     
    #2170 d3nt3dsh0v3l, Jan 11, 2018
    Last edited: Jan 11, 2018
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  11. thomps1523

    thomps1523 Established Member

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    That’s my biggest question... depends on if sheisido can turn vellus hairs terminal.
     
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  12. br1

    br1 Senior Member

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    I think you got it right. At least I have interpreted it the same.

    Riken = building new follicles "from scratch", by putting some cells together.
    RCH-01 = injecting one type of cell, which would migrate to the follicle, regenerating it - because DHT destroys these cells. The new cells being injected, are from immune follicles. (Note: on Replicel's promotional video, they say it "could happen" for new follicles to be formed - so I believe they are still to find out if it will happen)..
     
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  13. Georgie

    Georgie Senior Member My Regimen

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    Salivating at the thought of this
     
  14. Georgie

    Georgie Senior Member My Regimen

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    I’m super excited about all of this, but then I wonder: is this going to be available in my country? How much am I going to have to pay for this? Aaaand I feel depressed again
     
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  15. Georgie

    Georgie Senior Member My Regimen

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    Totally dreaming about showering without my hairs melting out of my head. Thick hair that can be easily styled and looks good without effort. Not envying everyone who has normal hair. God I hope this comes out soon.
     
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  16. Georgie

    Georgie Senior Member My Regimen

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    Just tread a fucking cap filled with stem cells needles and juice me up. Straight to every single follicle please.
     
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  17. Georgie

    Georgie Senior Member My Regimen

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    Yes
     
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  18. razzmatazz91

    razzmatazz91 Senior Member My Regimen

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    Poor poor reputation as a company. A dozen employees, and the only product being sold...or sale being attempted, is an injector.
    Check out views of investors and stock prices.

    Shiseido on the other hand is a cosmetic giant in Japan. Agreed. Shiseido is the only reason I have faith in RCH-01
     
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  19. MrV88

    MrV88 Experienced Member My Regimen

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    I think that Shiseido is the real deal in the whole process, as far as I know they got their own product/research for hair growth that hasn't been licensed and therefore an enhanced or maybe even combined treatment could well be available.

    A whole new research facility is quite an impressive move for "just a sideless mantaining".

    Even bioxcin or minoxidil adversed hair regrowth, really can't wait for the release of this.
     
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  20. That Guy

    That Guy Senior Member My Regimen

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    I am betting on it.

    At worst, Follica will be able to offer the results of the Dhurat study, which would already be enough for me and many others.

    We also know that the process can be repeated, and I've yet to hear one (scientific) argument that can explain why the results couldn't be increased further with repeat sessions.

    With RCH-01, we know that your hair will remain steadfast for at least five years, but possibly indefinitely as intended.

    For me, 2018 is a big deal for my hair because I'm waiting to see the Shiseido results and if Follica begins their pivotal or not. I really don't want to do a transplant if I don't have to. But I'm not a high Norwood, so it's better than nothing if it comes down to it and the meds have worked brilliantly for me.

    Either way, I'll be back to being a "fullhead oppressor" before my 30s and that is a comforting feeling.
     
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