Prolactin "minitherapy" with SMI-1 (novel protocol for lowering prolactin locally)

[Dimitri001]

Well, if all this turns out a bust (which I can't imagine it will), at least we've learned something new about the mechanics of hairloss and hopefully the scientists can use the new info to design further studies and advance the science.

 

[Will Be an Egg in 5 years]

So what was the outcome of the minoxidil Test For hairloss in Monkeys in comparison to the BAY ?

https://pubmed.ncbi.nlm.nih.gov/3558911/ From 1987

"The effect of topical minoxidil (5% and 2% solutions) on hair regrowth was studied in the frontal bald scalp of 18 adolescent and adult stump-tailed macaques (Macaca arctoides). Gross observation of the hairiness and folliculogram analysis of the skin biopsy specimens have shown that minoxidil induces the enlargement of vellus follicles to the size of middle to terminal follicles (regrowth of hair effect), minoxidil maintains the terminal follicles in the prebald scalp of periadolescent animals (prevention of baldness effect), enlarged follicles regress after minoxidil is withdrawn, and hair follicular growth is once again stimulated when treatment with minoxidil is reinstituted. Hair regrowth was more prominent in the early stage of baldness among younger macaques than in baldness of longer duration in older animals."

BAY apparently is even better because it also worked on older macaques and for a longer period

 

[Charger]

I've totally bought into the hype... waiting for this to be delivered is going to be brutal.

 

[Throwaway94]

I've totally bought into the hype... waiting for this to be delivered is going to be brutal.

Buying into GME at $94 a gram. Hold the line!

 

[czecha]

if this works, when will we know it does?

 

[fearofthereaper]

My only reservation is that for stump tailed macaques RU at 5% regrew a ton of hair ... I won’t remind everyone it’s efficacy in those on the forum (myself included)

on a side note has anyone pieced together any decent theory as to how this ties into the whole equation and why the PRLR is deemed to be a significant component of a condition deemed entirely androgenic ?

I think what's more incredible were the fact that the results were persistent after discontinuation. And didn't show any sign of slowing down. And, as pegasus mentioned, they were just superior overall

 

[Throwaway94]

if this works, when will we know it does?

We'll get our tendies around September-Dec

 

[czecha]

We'll get our tendies around September-Dec

wait it's that long just to get the compound? jfl, did you guys already order?

 

[Throwaway94]

wait it's that long just to get the compound? jfl, did you guys already order?

It'll be June by the time we receive it, I added 3-6 months for initial results

 

[Throwaway94]

It will take a couple months to get the compound, but we don't know yet if we can get BAY or if we have to settle for SMI-1.

Actually looks like settling for SMI-6, only one the lab is willing / able to synthesise

 

[FollicleGuardian]

This being SMI or BAY? I would be shocked if BAY doesn't work. I think SMI will probably work, but it wouldn't really surprise me if it didn't.

BAY

 

[Tom4362]

It's nice knowing my life does not depend on Samumed anymore lol

 

[Gegen]

It's nice knowing my life does not depend on Samumed anymore lol

I had some faith in these guys, until they removed half of their pipeline whereas they claimed they cured all the diseases that they were supposed to treat.
Wtf.

 

[1919]

If the withered titans of hairlosstalk still have hope after all the failures, I too will keep hoping.
BRACE YOUR SOULS THE HYPE TRAIN HAS ARRIVED!!! WE MIGHT CURE GUNNERSUP FROM INCELDOM!!!!!

 

[Charger]

WE MIGHT CURE GUNNERSUP FROM INCELDOM!!!!!

Dude's hairline could connect with his eyebrows and he'd still be emo and think he's nw8.

 

[Tom4362]

If the withered titans of hairlosstalk still have hope after all the failures, I too will keep hoping.

After reading this comment I feel more mature, in a weird way...

 

[1919]

After reading this comment I feel more mature, in a weird way...

Dont forget hairloss ages you 10 more years

 

[Throwaway94]

My only reservation is that for stump tailed macaques RU at 5% regrew a ton of hair ... I won’t remind everyone it’s efficacy in those on the forum (myself included)

on a side note has anyone pieced together any decent theory as to how this ties into the whole equation and why the PRLR is deemed to be a significant component of a condition deemed entirely androgenic ?

Perhaps it was prematurely deemed entirely androgenic?

 

[Will Be an Egg in 5 years]

If the withered titans of hairlosstalk still have hope after all the failures, I too will keep hoping.
BRACE YOUR SOULS THE HYPE TRAIN HAS ARRIVED!!! WE MIGHT CURE GUNNERSUP FROM INCELDOM!!!!!

Imagine curing baldness and realizing we're still miserable

 

[baldlygoing]

Imagine curing baldness and realizing we're still miserable

I can accept being miserable with hair