Kintor has started Phase 3 trial in China for Pyrilutamide

[5minutesbeforemiracle]

Theoretically, can it show long term results (10+ yrs) like finasteride?

Yes. However, for the next few years we will only know its 6 months efficacy.

 

[LoWS]

Yes, that's why Breezula is dosed at 7.5% to compensate for it's weakness. Pyrilutamide can't be dosed higher because it goes systemic at even 1.5x the tested dose (12mg), so what you see is what you will get.

So Kintor should not do a phase 3 trial of this drug in the US? It should focus more on the GT drug?

 

[trialAcc]

So Kintor should not do a phase 3 trial of this drug in the US? It should focus more on the GT drug?

No, they should and will. There's been nothing new on the market for 20+ years, they will do massive sales just on the hype and fact that it isn't likely to cause ED alone.

I'm happy to be proven wrong here but I just think there is enough evidence here to at least suggest they could have ran into similar issues to breezula and even RU in that these types of topicals are just not that effective. That hasn't stopped minoxidil 2% from selling hundreds of millions a year for decades despite doing almost nothing.

 

[LoWS]

No, they should and will. There's been nothing new on the market for 20+ years, they will do massive sales just on the hype and fact that it isn't likely to cause ED alone.

I'm happy to be proven wrong here but I just think there is enough evidence here to at least suggest they could have ran into similar issues to breezula and even RU in that these types of topicals are just not that effective. That hasn't stopped minoxidil 2% from selling hundreds of millions a year for decades despite doing almost nothing.

I saw in some thread there is a GB on kx , there results should atleast give us a hint of it's long term efficacy isn't it? By the end of the year we may have some data.

 

[fashy]

No, they should and will. There's been nothing new on the market for 20+ years, they will do massive sales just on the hype and fact that it isn't likely to cause ED alone.

I'm happy to be proven wrong here but I just think there is enough evidence here to at least suggest they could have ran into similar issues to breezula and even RU in that these types of topicals are just not that effective. That hasn't stopped minoxidil 2% from selling hundreds of millions a year for decades despite doing almost nothing.

I mean the only "evidence" is that they decided do a 6 months phase III trial in China instead of a 1 year one. It is a suspicious choice, but at the same time doesn't necessarily mean that it will not be up to par. Furthermore, with RU there have been reports of longer maintenance than 6 months for what it's worth and this should in theory be stronger than both Breezula and RU.

I think by the end of the year we will know, once all the GB have had ample time to test it out. Phase II results might also leave clues as to whether the effect diminishes as time goes on.

 

[trialAcc]

I mean the only "evidence" is that they decided do a 6 months phase III trial in China instead of a 1 year one. It is a suspicious choice, but at the same time doesn't necessarily mean that it will not be up to par. Furthermore, with RU there have been reports of longer maintenance than 6 months for what it's worth and this should in theory be stronger than both Breezula and RU.

I think by the end of the year we will know, once all the GB have had ample time to test it out. Phase II results might also leave clues as to whether the effect diminishes as time goes on.

What about the fact that you haven't seen any phase 2 results despite a phase 3 greenlit being almost over? Usually, when a company has top tier drug results they are screaming it at every publication who will listen, and that doubly goes for a company like Kintor who's stock dropped 80% due to a mishandled phase 3 trial around the same time that they had the phase 2 results ready to apply for phase 3.

Again, happy to be proven wrong, all I'm saying is to take whatever those results are with some skepticism. It will probably be a great addition for people with moderate hairloss, but it's probably not going to replace finasteride/dutasteride in guys with more advanced loss.

 

[Baldingtooyoung]

What about the fact that you haven't seen any phase 2 results despite a phase 3 greenlit being almost over? Usually, when a company has top tier drug results they are screaming it at every publication who will listen, and that doubly goes for a company like Kintor who's stock dropped 80% due to a mishandled phase 3 trial around the same time that they had the phase 2 results ready to apply for phase 3.

Again, happy to be proven wrong, all I'm saying is to take whatever those results are with some skepticism. It will probably be a great addition for people with moderate hairloss, but it's probably not going to replace finasteride/dutasteride in guys with more advanced loss.

Tbh, their Covid drug that seemed to fail has now favourable results as well. They didn't'scream' about those as well. We'll see. RU gives plenty of people years of stabilization. Nobody knows, Lets wait out the GB and june.

 

[badnewsbearer]

One difference though is that Pyrilutamide has a way higher binding affinity than breezula (breezula is super weak, like 30 times weaker than testosterone). So hopefully pyrilutamide can hold its results for longer.

but the dosage is also much weaker. that is another factor

 

[Baldingtooyoung]

How long are the GB guys now trying this? If Phase II results is good and the GB also report positive effects, I want to get this ASAP

 

[HMI 115 IS THE CURE dude]

Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial - PubMed

Orion Corporation Orion Pharma, Endo Pharmaceuticals Inc.

pubmed.ncbi.nlm.nih.gov

ODM-201 is a novel androgen receptor (AR) inhibitor designed to block the growth of prostate cancer cells through high-affinity binding to the AR and inhibition of AR nuclear translocation. This trial assessed ODM-201's safety, pharmacokinetics, and activity in men with metastatic castration-resistant prostate cancer.

this androgen receptor inhibitor can have really good uses for androgenic alopecia. It could have the same off label effect as finasteride. I wonder how the efficacies compare, in terms of hair growth. This is already completed phase 2 for prostate cancer

 

[Dimitri001]

One difference though is that Pyrilutamide has a way higher binding affinity than breezula (breezula is super weak, like 30 times weaker than testosterone). So hopefully pyrilutamide can hold its results for longer.

Not if the speculated AR upregulation is the reason for the dropoff in results. If anything it could lead to it falling off the cliff sooner.

 

[BetaBoy]

Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial - PubMed

Orion Corporation Orion Pharma, Endo Pharmaceuticals Inc.

pubmed.ncbi.nlm.nih.gov

ODM-201 is a novel androgen receptor (AR) inhibitor designed to block the growth of prostate cancer cells through high-affinity binding to the AR and inhibition of AR nuclear translocation. This trial assessed ODM-201's safety, pharmacokinetics, and activity in men with metastatic castration-resistant prostate cancer.

this androgen receptor inhibitor can have really good uses for androgenic alopecia. It could have the same off label effect as finasteride. I wonder how the efficacies compare, in terms of hair growth. This is already completed phase 2 for prostate cancer

lol it's well past phase II, ODM-201 or Nubeqa was approved way back in 2019

 

[JohnDoe5]

lol it's well past phase II, ODM-201 or Nubeqa was approved way back in 2019

I just checked and you ARE right. ODM-201 is being marketed under the name Nubequa. It is already on the market. It's been on the market since 2019. This guy, "HMI-115 is the cure" has had his head up his *** for so long he has forgotten what fresh air smells like. He's a toad.

 

[dahman]

How are the side effects looking from pyril?

 

[Dr sanches]

How are the side effects looking from pyril?

Heart palps and doesn’t even work

 

[Ljames]

Heart palps and doesn’t even work

You seem to have a real bee in your bonnet about pyril looking at your post history. Can you explain why?

If the group buys a failing and getting sides why has no one with a confirmed purchased said what you are?

The real answer is we just don't know until the results are show by the trial and though enough people having access to it on this forum get get a diverse sample size.

 

[Baldingtooyoung]

Heart palps and doesn’t even work

Can someone else from a GB say this is true?

 

[Dr sanches]

You seem to have a real bee in your bonnet about pyril looking at your post history. Can you explain why?

If the group buys a failing and getting sides why has no one with a confirmed purchased said what you are?

The real answer is we just don't know until the results are show by the trial and though enough people having access to it on this forum get get a diverse sample size.

You seem to have a real bee in your bonnet about pyril looking at your post history. Can you explain why?

If the group buys a failing and getting sides why has no one with a confirmed purchased said what you are?

The real answer is we just don't know until the results are show by the trial and though enough people having access to it on this forum get get a diverse sample size.

You seem to have a real bee in your bonnet about pyril looking at your post history. Can you explain why?

If the group buys a failing and getting sides why has no one with a confirmed purchased said what you are?

The real answer is we just don't know until the results are show by the trial and though enough people having access to it on this forum get get a diverse sample size.

sassumed had good phase 2 results then the phase 3 did bad and they are now shut down same with brotzu so many companies have made it to phase 3 kintor also is getting shitted on by other companies

 

[Baldingtooyoung]

sassumed had good phase 2 results then the phase 3 did bad and they are now shut down same with brotzu so many companies have made it to phase 3 kintor also is getting shitted on by other companies

Really hope you're wrong, as it is by far the most attainable product in the pipeline.

So nobody from the GB has results?

 

[bridge945]

Really hope you're wrong, as it is by far the most attainable product in the pipeline.

So nobody from the GB has results?

Don’t worry, this guy created an account recently, makes claims about a group buy from 6 months ago that there is no proof of, and exclusively shits on pyri. Unless he shows proof of this group buy, I wouldn’t listen to him at all