Kintor has started Phase 3 trial in China for Pyrilutamide

[Solid_Snake]

Saw this on tressless, don’t know if it was posted here. Says phase 2 results June 2022.

https://docs.publicnow.com/viewDoc?hash_primary=7E794443D5AFEBAC387B0FB449BFE31895923D5D

 

[Superman H_M]

Saw this on tressless, don’t know if it was posted here. Says phase 2 results June 2022.

https://docs.publicnow.com/viewDoc?hash_primary=7E794443D5AFEBAC387B0FB449BFE31895923D5D

Yes we were and are eagerly waiting for June, thanks for that document anyway.

Hope that the leaked results aren't bullshit haha !! Gonna be a fun wait ! Last time I was excited for results was for... Brotzu and their conference lmao
"Diameter doesn't change"

 

[whatevr]

Yes we were and are eagerly waiting for June, thanks for that document anyway.

Hope that the leaked results aren't bullshit haha !! Gonna be a fun wait ! Last time I was excited for results was for... Brotzu and their conference lmao
"Diameter doesn't change"

f*** if only the diameter didn't change, that would at least mean it had not gotten any worse, but it couldn't even do that.

 

[Ralph Wiggum]

What's the deal with group buys, are they legal or not so much?

 

[Baldingtooyoung]

I really start to hate it when i see a notification popping op on this or the HMI topic to only find out there are more stupid questions being asked.

 

[inmyhead]

Not sure if I'm allowed to say company names? But I might give it a go.seems expensive but $279 = £205 for 5000mg at 10mg a day is less than a pound a day, that's less than minoxadil.

I'm not American but they seem to be recruiting for trials

ClinicalTrials.gov

clinicaltrials.gov

Edit: actually I have a couple questions:
Is selleckchem legit?
What vehicle should I use, currently I use zix so can I just use alcohol/distilled water?
How is this stored in the freezer like RU?

I think you got the wrong price. Where do you see 280USD for 5g?

 

[vishal28]

I am confused too. It says 5mg for 270 USD and 40 USD for shipping. I am not taking the plunge until I see the June results

 

[fashy]

Allegedly, TAHC (Target area hair count) of pyrilutamide from the phase II study was 22.5/cm2 according to people who saw the leak. If true, and again that is a big if, these results are very encouraging.

 

[Kagaho]

Allegedly, TAHC (Target area hair count) of pyrilutamide from the phase II study was 22.5/cm2 according to people who saw the leak. If true, and again that is a big if, these results are very encouraging.

Remember this was a chinese study. Asian men tend to respond better to antiandrogens than caucasians.

I wouldnt expect KX to be more effective than finasteride or dutasteride. Excellent addition to the arsenal though.

 

[fashy]

As somebody mentioned in the discord, Dutasteride results in a phase III Korean study were 12.2/cm2. Koreans and Chinese are similar enough, which means that if the 22.5/cm2 result is true it should be significantly more effective than dutasteride.

 

[Kagaho]

Fair point. We'll see...

I still think people shouldnt expect much regrowth from the antiandrogenic angle. Even shutting down the T/DHT pathway almost completely (castration) didnt regrow significant amount of hair on its own.

 

[fashy]

Fair point. We'll see...

I still think people shouldnt expect much regrowth from the antiandrogenic angle. Even shutting down the T/DHT pathway almost completely (castration) didnt regrow significant amount of hair on its own.

If it can achieve long-term maintenance even with some minimal regrowth or thickening it's already a win in my book. I'm not in the pursuit of a juvenile NW1 hairline and I don't harbor any grand delusions, I'm quite happy to live with my NW3 hairline as long as it doesn't get any worse and becomes slightly more revitalized than it is right now.

 

[Kagaho]

If it can achieve long-term maintenance even with some minimal regrowth or thickening it's already a win in my book. I'm not in the pursuit of a juvenile NW1 hairline and I don't harbor any grand delusions, I'm quite happy to live with my NW3 hairline as long as it doesn't get any worse and becomes slightly more revitalized than it is right now.

Cool bro. Thats a realistic mindset. You can still go for some regrowth with DY dermarolling/stamping + minoxidil.

 

[badnewsbearer]

Allegedly, TAHC (Target area hair count) of pyrilutamide from the phase II study was 22.5/cm2 according to people who saw the leak. If true, and again that is a big if, these results are very encouraging.

just a friendly reminder that 6 months result of breezily was 21/cm^2 in TAHC. then after 12 months it went totally to sh*t. Kintor does not plan to do a 12 month phase 3 trial. they are both topical anti androgens and have a very comparable mechanism of action. so even if the leaked results were to be accurate and the side effect profile was to be favorable, who says that pyralutamide shares not the same property that it cannot maintain the regrowth for more than half a year. and we would never know because they do not have to do a 12 month trial. maybe they will have to do one for the FDA once they are in phase 3 in the US. but that will take another 1-2 years minimum

I still do not understand why breezula did so well initially and then so poorly when other anti androgens like finasteride or dutasteride really start to show the best results after 12-15 months. its strange because anti androgens take a long time to show their positive effects however with this one it seems to be potent initially and then diminish(breezula). personally I am hopeful that Pyrilutamide does not have this property

 

[mooreu]

just a friendly reminder that 6 months result of breezily was 21/cm^2 in TAHC. then after 12 months it went totally to sh*t. Kintor does not plan to do a 12 month phase 3 trial. they are both topical anti androgens and have a very comparable mechanism of action. so even if the leaked results were to be accurate and the side effect profile was to be favorable, who says that pyralutamide shares not the same property that it cannot maintain the regrowth for more than half a year. and we would never know because they do not have to do a 12 month trial. maybe they will have to do one for the FDA once they are in phase 3 in the US. but that will take another 1-2 years minimum

I still do not understand why breezula did so well initially and then so poorly when other anti androgens like finasteride or dutasteride really start to show the best results after 12-15 months. its strange because anti androgens take a long time to show their positive effects however with this one it seems to be potent initially and then diminish(breezula). personally I am hopeful that Pyrilutamide does not have this property

I was under the impression that Pyrilutamide was an androgen degrader. If so then its mode of action is far different than an anti-androgen like Breezula or RU. The safety profile would also be better.

 

[Adri23]

I was under the impression that Pyrilutamide was an androgen degrader. If so then its mode of action is far different than an anti-androgen like Breezula or RU. The safety profile would also be better.

Nahh the AR degrader is GT20029 and it is years away.

 

[trialAcc]

Allegedly, TAHC (Target area hair count) of pyrilutamide from the phase II study was 22.5/cm2 according to people who saw the leak. If true, and again that is a big if, these results are very encouraging.

Not to be that guy, but Breezula reported 20.7/cm2 increase at month 6 for their target dose as well. By month 12 it was 4.70/cm2 above base line, and I actually remember they did some weird reporting metric where the count was the difference from the control group, meaning that people were under baseline at 12 months on the top dose despite having an increase similar to KX at 6 months. Notice how every stack has a "significance vs baseline" star except for the 12 month?

Without a 12 month phase 3 these results are going to be pretty worthless. If I had to guess why they didn't do a 12 month phase 3, they probably saw a decease in hair counts towards the end of the trial.

 

[5minutesbeforemiracle]

just a friendly reminder that 6 months result of breezily was 21/cm^2 in TAHC. then after 12 months it went totally to sh*t. Kintor does not plan to do a 12 month phase 3 trial. they are both topical anti androgens and have a very comparable mechanism of action. so even if the leaked results were to be accurate and the side effect profile was to be favorable, who says that pyralutamide shares not the same property that it cannot maintain the regrowth for more than half a year. and we would never know because they do not have to do a 12 month trial. maybe they will have to do one for the FDA once they are in phase 3 in the US. but that will take another 1-2 years minimum

I still do not understand why breezula did so well initially and then so poorly when other anti androgens like finasteride or dutasteride really start to show the best results after 12-15 months. its strange because anti androgens take a long time to show their positive effects however with this one it seems to be potent initially and then diminish(breezula). personally I am hopeful that Pyrilutamide does not have this property

One difference though is that Pyrilutamide has a way higher binding affinity than breezula (breezula is super weak, like 30 times weaker than testosterone). So hopefully pyrilutamide can hold its results for longer.

 

[LoWS]

One difference though is that Pyrilutamide has a way higher binding affinity than breezula (breezula is super weak, like 30 times weaker than testosterone). So hopefully pyrilutamide can hold its results for longer.

Theoretically, can it show long term results (10+ yrs) like finasteride?

 

[trialAcc]

One difference though is that Pyrilutamide has a way higher binding affinity than breezula (breezula is super weak, like 30 times weaker than testosterone). So hopefully pyrilutamide can hold its results for longer.

Yes, that's why Breezula is dosed at 7.5% to compensate for it's weakness. Pyrilutamide can't be dosed higher because it goes systemic at even 1.5x the tested dose (12mg), so what you see is what you will get.