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Phase 2 results will be considered a "now or never" situation for HMI 115? Should we keep our expectations low?
HMI-115 PRLR antibody: The Most Promising Treatment Ever
- Thread starter pegasus2
- Start date
I don't see why it would be any better than phase I. Hopefully it can be an expensive finasteride replacement.
What is the point of having an alternative to finasteride? the only thing this looked promising for was regrowth...
Some people don't want to use finasteride, it's good they get an alternative. It seems to work a little better than finasteride too, but we'll see when they publish the data
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If the most hyped drug in decades ends up being just a bit better than finasteride, It'd be a huge disapointment
It is disappointing, but it doesn't do any good to dwell on that. At least we have an alternative now
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But the mechanism of action is different though. Wouldn't that mean using both gives more results and better prevention?
If the results are really comparable to Finasteride then they might not bother releasing this drug in hair loss form. The investors are going to operate as if there is already a pill on the market that does the same thing with no side-effect problem.
The misleading data from the Finasteride trials has cost us decades of investment into better prevention drugs. If the companies understood how prevalent the side-effect incidence is in real life, then alternatives (like topical RU58841) might already be at the local drugstore.
The misleading data from the Finasteride trials has cost us decades of investment into better prevention drugs. If the companies understood how prevalent the side-effect incidence is in real life, then alternatives (like topical RU58841) might already be at the local drugstore.
you have raised our expectations a lot, and now you say this, you are a sadist my friend
We are all disappointed with the results of HMI, but adults take things in stride.
Maybe it will be synergistic with microneeling, since HMI doesn't appear to work as well on slick bald areas
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Isn't it injected subcutaneously in the abdomen? I don't think microneedling will make much of difference. Nevertheless an alternative to finasteride is still a significant win in my book, only like a 100,000 - 200,000 american men use finasteride specifically for hairloss. Vast majority of finasteride's userbase is for prostate issues alone, very few men actually do anything about their balding
Microneeling is not about increasing absorption. It even works without any drug at all. Wounding does a lot of things like recruiting Wnt secreting macrophages.
Except the main point of having hair is to improve your chances to use your dick.
What results? Could you please share a link?
AFAIK HMI-115 just started Stage 2 trials, and you were defending the treatment just 2 pages before. What have changed?
Nothing has changed. The results are good, but they aren't as good as the macaques based on what we've seen from one patient. We are still waiting for their hair count numbers from phase I to have a better idea
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2 patients* His wife was also in the 16 person trial and he said she did not get as good results as he did (aka she got no results).
And she has no bald patches, so if she didn't improve thickness in non-bald areas, then it's not looking good. The only cope left would be that its mechanism is only effective in men, which is unlikely. But it's telling that Hope is only trialing men in phase 2 and not women.
And she has no bald patches, so if she didn't improve thickness in non-bald areas, then it's not looking good. The only cope left would be that its mechanism is only effective in men, which is unlikely. But it's telling that Hope is only trialing men in phase 2 and not women.
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That is not really the case, the influence of prolactin on alopecia is much more relevant in the case of women than in men. In all clinical trials, companies are much more reluctant to include women than men due to legal issues (pregnancies...), that does not mean it doesn't work. Furthermore, they are going to start this same treatment in women for endometriosis, which in the case of women is closely related to alopecia.
Is the dosage/protocol the same as in the hair trials?