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Histogen Interview w/ Dr. Gail Naughton

Discussion in '9th World Congress for Hair Research Conference' started by hellouser, Nov 25, 2015.

  1. hellouser

    hellouser Senior Member My Regimen

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    Keep this in mind:

    Histogen's HSC relies on it being injected in a pre-anagen stage. So, multiple injections may be necessary to get the injections 'right on schedule'. Perhaps many will affect all follicles eventually. We'll see eventually, but I'm really excited for Histogen.
     
  2. Emu

    Emu Established Member

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    The hair has been dyed for sure! In the first photo his hair is a brown and the second photo his hair is dark brown to black..

    I know it's a fake cos when my hair was at its worse,I would dye my hair and I would go from thinning hair to a much fuller look similar to the dudes photo they have provided.

    Im not saying that Histogen doesn't work just the photo is misleading.. So I can't trust this company now.
     
  3. hellouser

    hellouser Senior Member My Regimen

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    Camera settings like exposure and especially white balances will affect colours, which is why, like I've said in other threads, that making a 100% perfectly replicated 'after' photo is almost impossible. You'd need the exact same amount of light, the same bulbs with the same temperatures, the same camera, the same lens, the same distance from the subject, the same shutter speed, the same ISO setting, the same focal length, the same aperture setting, and the same position of the subject relative to the lighting in the room. You are NOT likely to do that many months apart. Take it from me as I do professional photography as well. What you're expecting is a controlled environment. But really, why would you need to have that? The difference is either cosmetically noticeable or not... and Histogen's results are clearly noticeable.

    Whatever the case me be, even if you dyed the guys hair in the before photo, there is absolutely no way he could have gotten that kind of growth in the front. No amount of combing over could do that, and there is no combing over present in the photo either. There's far too little hair in the front/forelock to do any kind of combover. These speculations really are stretching it, and I gotta be honest... some of these speculative comments make me laugh. The results are pretty clear; HSC definitely works VERY well.
     
  4. Dragonborn

    Dragonborn New Member

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    I'm with you 100%. The results are definitely cosmetically significant. That said Histogen might not be a cure but combining it with other treatments and eventually pilofocus might lead to low Norwood or full head of hair.
     
  5. newplayer

    newplayer Established Member

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    I'm backing this up 100% and I'm a graphic designer with history in professional photography.
    The results are amazing, I stand by this claim. Of course, I'm hoping to see more photos from male subjects.
     
  6. darwin101

    darwin101 Member

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    Again, and I'm a little surprised I have been ignored, what does the overall efficacy of the drug based on clinical trial data tell us about the treatment? Let's just ignore the ONE photo for a sec, and look at the broader picture. Does the data presented tell us histogen works?
     
  7. Swoop

    Swoop Senior Member My Regimen

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    The data does say it works but minoxidil performs better based on the data presented.
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  8. Superuser

    Superuser New Member

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    Could you please present those data for us?
     
  9. DoctorHouse

    DoctorHouse Senior Member

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    Yeah but at least you don't have to apply HSC twice a day for your whole life. The less we have to rely on minoxidil for regrowth is in big plus in my mind or maybe the results would be even better with minoxidil or finasteride. These are results from a stand alone treatment. We have to take into account that some of these new treatments might even work better with other treatments at the same time.
     
  10. paleocapa89

    paleocapa89 Established Member

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    Can you elaborate on this? I though minoxidil is not actually capable of growing more hair on your head but it activates the hair's anagen phase and makes it stay longer in that phase so it seems temporarily that you have more hair. But eventually you will lose that hair as well.
     
  11. S Foote.

    S Foote. Experienced Member

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    First thanks to Hellouser for his efforts and hard work here.

    I think the Histogen data is very interesting. They don't really pin down the precise action of the injected "cocktail", but i would point out something significant that can be seen in the close up pics on their website.

    First i should explain the background to my own views for those who don't already know. I think hair loss research took a wrong turn many years ago, and this is the reason for the on-going delay in producing more effective treatments. My personal critique of historic hair research can be read here.

    https://independent.academia.edu/StephenFoote/Papers

    The simple fact is that hair loss research is all about finding the cause of restricted growth of the anagen follicle. Yet current hair growth research ignores the most basic tissue growth control of all in recognised Physiology. According to mainstream science this universal control has the final say on all normal tissue enlargement in-vivo, and so must also apply to hair follicle enlargement in-vivo.

    This is described in my article linked above, and basically means to increase hair growth we need to shrink the tissue around the follicles. One clear sign of tissue shrinkage is a crazing or wrinkling of the skin. People are aware of this effect with Minoxidil.

    The baseline and one year close up pictures on the histogen site, also clearly show this wrinkling of the skin in the after one year picture. http://www.histogen.com/applications/hsc.htm

    Best to copy save then enlarge to see in detail.

    The other important thing about this universal growth control is that any attempts to get around it will fail, or be deemed to dangerous to be licensed. This spatial growth control prevents tissue growth from invading other tissues, and only cancer cells can get around this. There is some relaxation of this control in the healing process, and this is in line with the wounding effects being researched in hair growth.

    But messing with the WNT's pathway and other strategies to get around this natural growth restriction, is asking for trouble and not necessary anyway.

    With a little focused research on reducing the external conditions that restrict follicle growth, we could have more effective, cheaper, and safer treatments.
     
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  12. Armando Jose

    Armando Jose Senior Member My Regimen

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    +1
     
  13. TheShining

    TheShining Established Member

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    Give me one reason of why they would darken a selection of the picture and not the full picture..? There is absolutely no logic behind that.
     
  14. resu

    resu Senior Member

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    Maybe they were clumsy when editing the pics or maybe it's an optical illusion or camera glitch.
     
  15. EvilLocks

    EvilLocks Senior Member

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    I didn't get a chance to listen to this in it's entirety until now, but I have to say, WOW, can't believe you thought of me when you interviewed her! I'm very touched that you thought of me and mentioned me in the interview - THANKS a million! I have said it before but I'll say it again; it truly means a LOT that you did this for us. I'm excited about the future treatments and keep my fingers crossed we will have access to better treatments in as short amount of time as possible. Again, THANK YOU.
     
    WhitePolarBear likes this.
  16. Folliman

    Folliman Established Member

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    I'm glad the results will be long lasting. I think it's going to be the big 4 when this becomes available. :)
     
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  17. hiitsjam

    hiitsjam New Member

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    Here is another interview with Dr. Gail Naughton on BTT https://www.*********talk.com/threa...015-World-Congress-Presentation-and-Interview

    After listening the whole interview (she has also presented the recent Histogen presentations), I am getting a great confidence in histogen now. I have been extremely negative about this company in the past but the recent results are quite impressive both from efficacy and safety perspective.

    To me it seems like within few years, this product should be out in the market. I am very excited :)
     
  18. Blackber

    Blackber Experienced Member

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    Any update on the bold text quoted above? I know you can't post it without her permission but I'm assuming it could be categorized as good news versus bad news...?

    Forgive my ignorance but does Mexico have it's own government regulatory institute similar to the FDA or do they work in conjunction with the US FDA? I have to listen to the interview again but from what I think I remember Dr. Naughton said they haven't started any approval process in Mexico yet but she's hopeful it may be available there sometime in 2017. I'm not following how that would be possible unless Mexico would be satisfied by the trials she's already completed in the US. If you could further explain your knowledge/take on this it would be much appreciated.

    I'm very hopeful for all of this, I'm just seeking a better understanding for myself. It would be wonderful for all of us located in North/Central/South America to have a closer treatment available to us as opposed to anything coming to fruition in Japan. It can save us all some money while buying us time for treatments to be approved in the US/Canada.

    Again hellouser, I'd like to thank you on behalf of everyone for doing this. I don't post much on the forums but I frequent them a lot and thank you and all the other members that provide us with accurate information instead of just hearsay.
     
  19. NewUser

    NewUser Experienced Member

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    I am very excited about Histogen esp. Dr Ziering's result - it's breathtaking. Looked it up and Ziering is in his 50's! I'm 51 and have a little more in front, but less in crown, compared to Ziering pre-treatment.

    One question I thought of after reading about cell therapy tourism in countries like Mexico offering unproven procedures is, has Histogen followed FDA regulations for clinical trials and, are they seeking the legal ability to advertise Histogen HSC in the USA? If so, which states are they looking at for release? I do understand that they want to license the procedure to another party, and so would it be a large company, like Bosley or a chain of clinics like Bosley?

    Also, would Clinics in Mexico participate in ongoing clinical trials to prove efficacy, or would they be strictly for-profit clinics?

    In which country's lab would injectable HSC be manufactured, Mexico or USA?

    Thanks to to hellouser for all of this wonderful news and insight.
     
    #79 NewUser, Dec 2, 2015
    Last edited: Dec 2, 2015
  20. INT

    INT Senior Member

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    What could Histogen mean for you if you are a Norwood 2 and just looking to maintain?
     

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