Good Results With Topical Certizine

[jgray201]

Where are the accounts of people saying they had significant losses on topical cetirizine? I would be interested in reading them if you can steer me in the right direction. My recollection of the trials a few years ago was that people generally had results. I think the main issues were that people started to feel that results and new growth did not really kick on, or they started experimenting with the vehicle and then didnt stick with it long enough.

 

[heyhey]

Where are the accounts of people saying they had significant losses on topical cetirizine? I would be interested in reading them if you can steer me in the right direction. My recollection of the trials a few years ago was that people generally had results. I think the main issues were that people started to feel that results and new growth did not really kick on, or they started experimenting with the vehicle and then didnt stick with it long enough.

You will have people saying they loose hair from all kinds of treatments, people claims minoxidil or finasteride made them bald....
Most likely people just wants to blame something else than their genes.

 

[heyhey]

Here is a picture of the growth in the temples i have had, it is still very thin but basically i got a very weak nw1 hairline.

 

[heyhey]

I should add that it was some hairs before at that temple not 100% slick bald maybe as i said before, but they were were just vellus.

 

[proscar2]

@ kiwipilu Established Member

You only trust science and scientific conclusions. Then your in for a lot of depression my friend.

I know enough to take on board scientific results BACKED UP by real world results my friend. glad the dermaroller study went well for you. Please try all the thousands of studies that offer MAJOR RESULTS and then fail real world. I ASSUME these will all work as well according to your logic? Let me know how cert goes. It will most likely go the way it did in the many trials conducted before on the forums. please prove me wrong.



O&OUT

 

[proscar2]

according to these people your 'missing' the boat with cert. opinions please


http://www.hairsite.com/hair-loss/board_entry-id-105629-page-0-order-last_answer-category-4.html

http://www.hairlosshelp.com/forums/...=101616&STARTPAGE=4&FTVAR_FORUMVIEWTMP=Linear



Originally posted by: GansterBoy

Certrizine inhibits pgd2 produced by mast cells.... and NOT by Lpgds. pgd2 produced in hair folicles is not from mast cells... waste of time.

in other words your missing the boat with mast cell inhibitors..

Inflamation/ PGD-2 and Mast Cell Degranulation?

Have you seen this? GangsterBoy posted it over at HLH


PGD2 in hair folicles is not caused by HPGDS - hematopoietic prostaglandin D synthase BUT, by LPGDS lipocalin pgds.

Source? read the 22 march study of DR. cots. LPGds levels are highly elevated....

http://www.ncbi.nlm.nih.gov/pm...bin/nihms366359f2.jpg


Increased PGD2 pathway activity in balding scalp of men with Androgenetic Alopecia. (A) Expression of lipocalin-type PTGDS mRNA in bald versus haired scalp, as tested by qPCR. Data are means � SEM (n = 4). (B and C) The amount of PTGDS protein in paired bald (B) and haired (H) scalps (n = 4), as shown by Western blotting with Ponceau stain used for verification of equal loading (B) and its quantitation as normalized to haired scalp (C). Data are means � SEM. (D) PGD2 production in bald scalp, as tested by ELISA. Data are means � SEM (n = 3). (E and F) Fold change in PGD2 (n = 17), 15-dPGJ2) (n = 7), and PGE2 (n = 17) expression in bald scalp compared to haired scalp (E). Total prostaglandin content is quantified in (F). Data are means � SEM. *P < 0.05; **P < 0.01. In (F), P value compares haired versus bald samples for each prostaglandin.

knowing this, explain why cetrizine and other mastcell stabelizers, will NOT help against the elevated PGD2 in hairflocles.. so your basically missing the boat with hpgds stabilizers.

 

[proscar2]

Christ- this this the last time I'll post on this subject; if people really want to try a PROPER TEST to see if it works, try using some common sense and SPEND some money, buy the proper powder and use it in a mirror image test of seti? As they work in a related (related mind) manor.

I suggest one uses CERTRI bulk, i.e a 20% powder in a vehicle - same percentagethat alibaba (member not the website) is using for seti and getting GOOD results! (i can confirm he is getting results on seti at.

Please no mentally unbalanced individuals pm'ing me saying prove it!- you either take my word or you dont!

if seti, a relatively new molecule, requires a large percentage based solution to produce proper results (alibaba results improved massively form 5% to 20%- i would never have envisaged using this amount so kudos to him) then perhaps by applying a similar logic to certrizine it may yield better results, though i doubt it.

I'm not convinced, but if your gonna try - at least TRY PROPERLY. Cant people see that they should call time with crushing up a few pills in fillers and hoping for miracles- experiment properly.

 

[kiwipilu]

@proscar2 check pm I don't want this threead to be flooded.

 

[proscar2]

kiwipilu Established Member, responded!

 

[jamesbooker1975]

Why you keep this to yourself bucko? Jokes good for you

Don't understand you. I already post about this.

 

[Seuxin]

Christ- this this the last time I'll post on this subject; if people really want to try a PROPER TEST to see if it works, try using some common sense and SPEND some money, buy the proper powder and use it in a mirror image test of seti? As they work in a related (related mind) manor.

I suggest one uses CERTRI bulk, i.e a 20% powder in a vehicle - same percentagethat alibaba (member not the website) is using for seti and getting GOOD results! (i can confirm he is getting results on seti at.

Please no mentally unbalanced individuals pm'ing me saying prove it!- you either take my word or you dont!

if seti, a relatively new molecule, requires a large percentage based solution to produce proper results (alibaba results improved massively form 5% to 20%- i would never have envisaged using this amount so kudos to him) then perhaps by applying a similar logic to certrizine it may yield better results, though i doubt it.

I'm not convinced, but if your gonna try - at least TRY PROPERLY. Cant people see that they should call time with crushing up a few pills in fillers and hoping for miracles- experiment properly.

Hello !

Humm i have difficulties to understand what do you mean :S

You mean : Guys, buy seti and use at 20% in a topical vehicle ?
or
You man : Guys, try large amount Cetirizine.

Thanks

 

[Jk1]

just started cetrizine oral oil drops its 10mg/ml and already a liquid ! so easy to apply is this one percent ?

im gona try half my head for 3 months and see if i notice a difference. it does reduce any itch thats for sure !

is their any interaction with ketoconazole or lactate shampoo ? i.e i should or shouldnt use on those days ?

 

[DavidMark]

The_Mentalist put together a detailed post about how to formulate a cetrizine solution.

I would send y'all to the actual thread but being a new member, I can't post URLs. Instead, I've just copied and pasted his recipe. Everything below is from the user, The_Mentalist (major probs brah)




This is an inexpensive home remedy and many of you already know it has been reported to benefit Androgenetic Alopecia hairloss by blocking pdg2 anti-inflammatory response. You be the judge

Here is how to make a cetirizine topical

A)

1. crush and grind 33 tablets (10mg each) into a powder

2. dissolve the powder in 50 ml of distilled water

3. let it stand for at least 24 hours

4. since pills are made up of insoluble filler material and the active ingredient which is soluble, after 24 hours the active ingredient will be dissolved in the water above the filler material. For this reason the water above the granulate powder needs to be carefully separated and the powder discarded. This can be done using a syringe or a pipette or even a dropper

5. add 30 ml of Ethanol (roughly 70%) to the remaining 50 ml of water.

6. finally mix with 20 ml of Propylene glycol


So, we end up with 330 mg dissolved in 100ml vehicle solution. And this will give us only .33% solution. It does not appear to be super concentrated. I am not sure what dosage/frequency and conc. people have used or are using. But, it should be at least 1 ml per day everyday.

Thus, with that dose, approx. 3.3 mg will enter scalp. This is a good concentration considering that per day recommended dose for Cetitrizine against Allergy is 10mg systemic for adults; or even 5 mg for children or some adults. So, this should still be quite a high dosage for 3.3 mg that will be primarily concentrated on scalp area only, and not throughout the body first


B)

I read somewhere that alcohol may cause degradation of Cet. molecules, thus making it inactive or week. SO here is a simpler remedy

1. water solubility of Cet. is, what I found, 160g/100 ml, which translates into 1600 mg/ml, a very high solubility. But, we only need about roughly 0.33% solution.

2. so, to make about three months or so, supply of using 1 ml once a day, with conc. of roughly 0.33% solution (1 ml is what you use for minoxidil per dose/dropper)

3. pour 100 ml of distilled water in a clean small bottle or any container that is narrow and high, not wide or spread out

4. take 33 x 10 mg Cet tabs, for a total of 330 mg tabs, in a napkin, fold it, and crush it with anything solid like kitchen knife handle

5. OR simply drop 33 tabs into the distilled water and shake it gently

6. Let it settle for several hours and occasionally shaking it to punch the tabs into dissolving more rapidly

7. Let it settle for several hours; you will see the bnders settling in the bottom, and water above would be clear to cloudy depending on Cet. brand you used

8. water above the binders has Cet. dissolved in it, so either very gently and slowly pour out the water into a clean bottle or use your minoxidil dropper to squeeze water out of the container without disturbing the binders settled at bottom

9. You will have roughly .33%+ Cet solution in pure water


C)

Since water may dry too quickly on scalp or if you feel so, then I would add little bit of minoxidil sol. into the whole potion and you will find that even little addition will have some greasy quality to the Cet. solution. It will make the Cet solution not dry so rapidly and would stay on scalp for sufficient time for Cet to absorp


Tips

- Zyrtec/store brand eg CVS/Wags/Rite Aid, are inexpensive, over the counter and come in 10mg and 5mg tabs

- use distilled water, if possible. Any other water, containing ions etc., has the potential for rendering Cet. inactive

- I was surprised to read somewhere that Cet. is not available or is not over the counter. If you are in that country where you cant find it, check ebay to see if they will ship it to you. Do a search on "Cetirizine" or Zyrtec

- no need for Zyrtec, which is quite expensive compared to generic alternatives. ANy will do. The only difference you may find is that Zyrtec brand seems to give a clearer final solution


- I believe this will go systemic. You will notice or pay attention that your nose sputum (word?) will vecome drier and you will be easily able to pick your nose with dry residue. On days, you not use it, you MAY find runny nose. This is a good sign that the solution does absorb into your scalp (and eventually some systemic)

- use the minoxidil dropper to transport solution to scalp, not hair, and massage thoroughly

- some have been dissolving it into minoxidil solution. This is not a good idea. There is a whisper on the net that Cet. degrades minoxidil, or if left in it for too long. We dont know how long is "too long." So, lets not take a risk, and use simple water solution if possible

- be wise, and try to play around with the dose application and/or tinker around making the solution to see what works best for you. There is no hard and fast rule how much of each is best established-it is all your own experiment



Request

I know there is a thread already for this. But, it is so cluttered with NUMEROUS pages and dialogue that it is hard to deduce what percent users have gotten results and to what extent. If you have already used it or decide to try this regimen, please come back and/or post your results concisely here for everyone to read them in one thread, free of multiple unnecessary pages of ceaseless arguments.

Ideal person we would like to hear from would be a) anyone not using anything else but this, or b) anyone who has a stale/stabilized regimen and can actually deduce the benefits, if any, of this regimen on its own.

To be objective, please try to organize your results/observation in this format, if you will

A) When you first started, what dose/frequency, and approx. what conc. solution

B) Any regimen you are/were on when started this trial. Any details

C) When you first noticed hair benefit and at what degree, what part of scalp etc. Benefits=stop shedding, or regrowth of vellus hair or dark hair etc

G) What makes you think it is this regimen result rather than other regimen you may have recently started-Your intuitive thoughts

H) Any side effects: Hair quality, heart rate, urine frequency, scalp acne/bumps



Lastly,

Keep this post uncluttered. Be respectful of other posters who are looking for relevant information and not arguments and speculations, so post if you have something substantial to contribute relevant to the topic. Simply posting to say that "I will start this tomorrow," is not wise. But, please do post your experience with this regimen to share with us and to help others.

 

[proscar2]

after posting about suggesting trying a large percentage 20% based solution with REAL powder no fillers (similar to results with seti- aka member alibaba).................its back to crushing tablets

if people are getting minimal results using seti at 5%.............!

 

[Jk1]

The_Mentalist put together a detailed post about how to formulate a cetrizine solution.

I would send y'all to the actual thread but being a new member, I can't post URLs. Instead, I've just copied and pasted his recipe. Everything below is from the user, The_Mentalist (major probs brah)




This is an inexpensive home remedy and many of you already know it has been reported to benefit Androgenetic Alopecia hairloss by blocking pdg2 anti-inflammatory response. You be the judge

Here is how to make a cetirizine topical

A)

1. crush and grind 33 tablets (10mg each) into a powder

2. dissolve the powder in 50 ml of distilled water

3. let it stand for at least 24 hours

4. since pills are made up of insoluble filler material and the active ingredient which is soluble, after 24 hours the active ingredient will be dissolved in the water above the filler material. For this reason the water above the granulate powder needs to be carefully separated and the powder discarded. This can be done using a syringe or a pipette or even a dropper

5. add 30 ml of Ethanol (roughly 70%) to the remaining 50 ml of water.

6. finally mix with 20 ml of Propylene glycol


So, we end up with 330 mg dissolved in 100ml vehicle solution. And this will give us only .33% solution. It does not appear to be super concentrated. I am not sure what dosage/frequency and conc. people have used or are using. But, it should be at least 1 ml per day everyday.

Thus, with that dose, approx. 3.3 mg will enter scalp. This is a good concentration considering that per day recommended dose for Cetitrizine against Allergy is 10mg systemic for adults; or even 5 mg for children or some adults. So, this should still be quite a high dosage for 3.3 mg that will be primarily concentrated on scalp area only, and not throughout the body first


B)

I read somewhere that alcohol may cause degradation of Cet. molecules, thus making it inactive or week. SO here is a simpler remedy

1. water solubility of Cet. is, what I found, 160g/100 ml, which translates into 1600 mg/ml, a very high solubility. But, we only need about roughly 0.33% solution.

2. so, to make about three months or so, supply of using 1 ml once a day, with conc. of roughly 0.33% solution (1 ml is what you use for minoxidil per dose/dropper)

3. pour 100 ml of distilled water in a clean small bottle or any container that is narrow and high, not wide or spread out

4. take 33 x 10 mg Cet tabs, for a total of 330 mg tabs, in a napkin, fold it, and crush it with anything solid like kitchen knife handle

5. OR simply drop 33 tabs into the distilled water and shake it gently

6. Let it settle for several hours and occasionally shaking it to punch the tabs into dissolving more rapidly

7. Let it settle for several hours; you will see the bnders settling in the bottom, and water above would be clear to cloudy depending on Cet. brand you used

8. water above the binders has Cet. dissolved in it, so either very gently and slowly pour out the water into a clean bottle or use your minoxidil dropper to squeeze water out of the container without disturbing the binders settled at bottom

9. You will have roughly .33%+ Cet solution in pure water


C)

Since water may dry too quickly on scalp or if you feel so, then I would add little bit of minoxidil sol. into the whole potion and you will find that even little addition will have some greasy quality to the Cet. solution. It will make the Cet solution not dry so rapidly and would stay on scalp for sufficient time for Cet to absorp


Tips

- Zyrtec/store brand eg CVS/Wags/Rite Aid, are inexpensive, over the counter and come in 10mg and 5mg tabs

- use distilled water, if possible. Any other water, containing ions etc., has the potential for rendering Cet. inactive

- I was surprised to read somewhere that Cet. is not available or is not over the counter. If you are in that country where you cant find it, check ebay to see if they will ship it to you. Do a search on "Cetirizine" or Zyrtec

- no need for Zyrtec, which is quite expensive compared to generic alternatives. ANy will do. The only difference you may find is that Zyrtec brand seems to give a clearer final solution


- I believe this will go systemic. You will notice or pay attention that your nose sputum (word?) will vecome drier and you will be easily able to pick your nose with dry residue. On days, you not use it, you MAY find runny nose. This is a good sign that the solution does absorb into your scalp (and eventually some systemic)

- use the minoxidil dropper to transport solution to scalp, not hair, and massage thoroughly

- some have been dissolving it into minoxidil solution. This is not a good idea. There is a whisper on the net that Cet. degrades minoxidil, or if left in it for too long. We dont know how long is "too long." So, lets not take a risk, and use simple water solution if possible

- be wise, and try to play around with the dose application and/or tinker around making the solution to see what works best for you. There is no hard and fast rule how much of each is best established-it is all your own experiment



Request

I know there is a thread already for this. But, it is so cluttered with NUMEROUS pages and dialogue that it is hard to deduce what percent users have gotten results and to what extent. If you have already used it or decide to try this regimen, please come back and/or post your results concisely here for everyone to read them in one thread, free of multiple unnecessary pages of ceaseless arguments.

Ideal person we would like to hear from would be a) anyone not using anything else but this, or b) anyone who has a stale/stabilized regimen and can actually deduce the benefits, if any, of this regimen on its own.

To be objective, please try to organize your results/observation in this format, if you will

A) When you first started, what dose/frequency, and approx. what conc. solution

B) Any regimen you are/were on when started this trial. Any details

C) When you first noticed hair benefit and at what degree, what part of scalp etc. Benefits=stop shedding, or regrowth of vellus hair or dark hair etc

G) What makes you think it is this regimen result rather than other regimen you may have recently started-Your intuitive thoughts

H) Any side effects: Hair quality, heart rate, urine frequency, scalp acne/bumps



Lastly,

Keep this post uncluttered. Be respectful of other posters who are looking for relevant information and not arguments and speculations, so post if you have something substantial to contribute relevant to the topic. Simply posting to say that "I will start this tomorrow," is not wise. But, please do post your experience with this regimen to share with us and to help others.

why make a custom lotion when u can get the zyrtec oral drops that are 10mg/ml or 1pcnt which is the same concentration as in that hairloss study with cetrizine from 2017 ?

 

[Zoro]

why make a custom lotion when u can get the zyrtec oral drops that are 10mg/ml or 1pcnt which is the same concentration as in that hairloss study with cetrizine from 2017 ?

because a custom vehicle is better for topical absorption, the liquid cet is basically cet in sugar water

 

[Jk1]

well i guess you could add these drops to something else to get better absorption ? like stemoxidyne or minoxidil ? or ethanol

but is it needed ? so far i can clearly tell a lot less itching scalp on that side...

i never heard of adsorption issue with cetrizine

 

[heyhey]

Yes certizine dries out kinda quickly, thats sad. But perhaps its still better to go on with the non alcoholic form of it, cause ethanol degrades certizine as some have said.

 

[heyhey]

perhaps it absorbes better if put on after a warm shower.

 

[jamesbooker1975]

because a custom vehicle is better for topical absorption, the liquid cet is basically cet in sugar water

No, it is not . It have Propilen glycol as vehicle . And sugar is not use it , just some flavour .